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Propolis prevents aluminium-induced genetic and hepatic damages in rat liver.

Abstract

Aluminium is present in several manufactured foods and medicines and is also used in water purification. Therefore, the present experiment was undertaken to determine the effectiveness of propolis in modulating the aluminium chloride (AlCl(3)) induced genotoxicity and hepatotoxicity in liver of rats. Animals were assigned to 1 of 4 groups: control; 34 mg AlCl(3)/kg bw; 50mg propolis/kg bw; AlCl(3) (34 mg/kg bw) plus propolis (50mg/kg bw), respectively. Rats were orally administered their respective doses daily for 30 days. At the end of the experiment, rats were anesthetized and hepatocytes (HEP) were isolated for counting the number of micronucleated hepatocytes (MNHEPs). In addition, the levels of serum enzymes and histological alterations in liver were investigated. AlCl(3) caused a significant increase in MNHEPs, alkaline phosphatase, transaminases (AST and ALT) and lactate dehydrogenase (LDH). Furthermore, severe pathological damages such as: sinusoidal dilatation, congestion of central vein, lipid accumulation and lymphocyte infiltration were established in liver. On the contrary, treatment with propolis alone did not cause any adverse effect on above parameters. Moreover, simultaneous treatments with propolis significantly modulated the toxic effects of AlCl(3). It can be concluded that propolis has beneficial influences and could be able to antagonize AlCl(3) toxicity.

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  • Authors+Show Affiliations

    ,

    Department of Biology, Faculty of Sciences, Atatürk University, 25240 Erzurum, Turkey.

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    Source

    MeSH

    Alanine Transaminase
    Alkaline Phosphatase
    Aluminum Compounds
    Animals
    Antimutagenic Agents
    Aspartate Aminotransferases
    Chlorides
    Drug-Induced Liver Injury
    Hepatocytes
    L-Lactate Dehydrogenase
    Liver
    Liver Function Tests
    Male
    Micronucleus Tests
    Oxidative Stress
    Propolis
    Rats
    Rats, Sprague-Dawley

    Pub Type(s)

    Journal Article
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    20637254