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Characterization of macrolide resistance in Mycoplasma pneumoniae isolated from children in Shanghai, China.
Diagn Microbiol Infect Dis. 2010 Aug; 67(4):355-8.DM

Abstract

One hundred Mycoplasma pneumoniae strains were isolated from pediatric patients from March 2008 to July 2009. Of 100 isolates, 90 (90%) were resistant to erythromycin (MICs >128 microg/mL for 88 strains and 64 microg/mL for 2 strains), azithromycin, and clarithromycin. Fluoroquinolones and tetracyclines maintain good activities against clinical M. pneumoniae isolates. Of 90 macrolide-resistant M. pneumoniae strains, 88 (98%) harbored an A-to-G transition mutation at position 2063 in 23S rRNA genes, and the remaining 2 showed either A2064G or A2063T mutation; the latter point mutation is newly discovered and reported. Ninety-three (93%) clinical isolates were classified into the P1 gene restriction fragment length polymorphism (RFLP) type I, and 7 (7%) were type II.

Authors+Show Affiliations

Institute of Antibiotics, Huashan Hospital, Fudan University, Shanghai 200040, PR China.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

20638604

Citation

Liu, Yang, et al. "Characterization of Macrolide Resistance in Mycoplasma Pneumoniae Isolated From Children in Shanghai, China." Diagnostic Microbiology and Infectious Disease, vol. 67, no. 4, 2010, pp. 355-8.
Liu Y, Ye X, Zhang H, et al. Characterization of macrolide resistance in Mycoplasma pneumoniae isolated from children in Shanghai, China. Diagn Microbiol Infect Dis. 2010;67(4):355-8.
Liu, Y., Ye, X., Zhang, H., Xu, X., Li, W., Zhu, D., & Wang, M. (2010). Characterization of macrolide resistance in Mycoplasma pneumoniae isolated from children in Shanghai, China. Diagnostic Microbiology and Infectious Disease, 67(4), 355-8. https://doi.org/10.1016/j.diagmicrobio.2010.03.004
Liu Y, et al. Characterization of Macrolide Resistance in Mycoplasma Pneumoniae Isolated From Children in Shanghai, China. Diagn Microbiol Infect Dis. 2010;67(4):355-8. PubMed PMID: 20638604.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Characterization of macrolide resistance in Mycoplasma pneumoniae isolated from children in Shanghai, China. AU - Liu,Yang, AU - Ye,Xinyu, AU - Zhang,Hong, AU - Xu,Xiaogang, AU - Li,Wanhua, AU - Zhu,Demei, AU - Wang,Minggui, PY - 2009/11/30/received PY - 2010/02/27/revised PY - 2010/03/12/accepted PY - 2010/7/20/entrez PY - 2010/7/20/pubmed PY - 2010/10/20/medline SP - 355 EP - 8 JF - Diagnostic microbiology and infectious disease JO - Diagn Microbiol Infect Dis VL - 67 IS - 4 N2 - One hundred Mycoplasma pneumoniae strains were isolated from pediatric patients from March 2008 to July 2009. Of 100 isolates, 90 (90%) were resistant to erythromycin (MICs >128 microg/mL for 88 strains and 64 microg/mL for 2 strains), azithromycin, and clarithromycin. Fluoroquinolones and tetracyclines maintain good activities against clinical M. pneumoniae isolates. Of 90 macrolide-resistant M. pneumoniae strains, 88 (98%) harbored an A-to-G transition mutation at position 2063 in 23S rRNA genes, and the remaining 2 showed either A2064G or A2063T mutation; the latter point mutation is newly discovered and reported. Ninety-three (93%) clinical isolates were classified into the P1 gene restriction fragment length polymorphism (RFLP) type I, and 7 (7%) were type II. SN - 1879-0070 UR - https://www.unboundmedicine.com/medline/citation/20638604/Characterization_of_macrolide_resistance_in_Mycoplasma_pneumoniae_isolated_from_children_in_Shanghai_China_ DB - PRIME DP - Unbound Medicine ER -