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High polymorphism of the MBL2 gene in patients with atopic dermatitis.
Ann Allergy Asthma Immunol. 2010 Jul; 105(1):39-42.AA

Abstract

BACKGROUND

Low serum levels of mannose-binding lectin (MBL) are determined mainly by variant alleles of the MBL2 gene and it has been suggested that MBL may play a role in the susceptibility to atopic dermatitis (AD).

OBJECTIVE

The aim was to investigate the difference of the frequency of MBL2 variant alleles in AD patients and in a group of individuals without AD, and associate the MBL2 alleles with AD severity.

METHODS

MBL2 variant allele's frequency was investigated in 131 children with AD and 165 healthy children/adolescents matched by convenience. The severity of disease was graded according to the SCORing Atopic Dermatitis (SCORAD) index. The first exon variants were called "O" and the wild type "A". The variants in the promoter were H/L at -550 and X/Y at -221, determined by Real Time PCR.

RESULTS

Children with AD had higher frequency of allele O and the genotypes related to low or deficient levels of MBL, when compared to the healthy group (p = 0.0012 and p < 0.001, respectively), but not with AD severity.

CONCLUSION

Low or deficient MBL serum levels determined genetically may contribute to the predisposition for AD, but not for disease severity.

Authors+Show Affiliations

Department of Dermatology, Instituto Materno Infantil de Pernambuco, Recife, Brazil.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

20642202

Citation

Carréra, Matilde Campos, et al. "High Polymorphism of the MBL2 Gene in Patients With Atopic Dermatitis." Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology, vol. 105, no. 1, 2010, pp. 39-42.
Carréra MC, Moura P, Crovella S, et al. High polymorphism of the MBL2 gene in patients with atopic dermatitis. Ann Allergy Asthma Immunol. 2010;105(1):39-42.
Carréra, M. C., Moura, P., Crovella, S., de Souza, P. R., de Alencar, L. C., & Sarinho, E. (2010). High polymorphism of the MBL2 gene in patients with atopic dermatitis. Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology, 105(1), 39-42. https://doi.org/10.1016/j.anai.2010.03.017
Carréra MC, et al. High Polymorphism of the MBL2 Gene in Patients With Atopic Dermatitis. Ann Allergy Asthma Immunol. 2010;105(1):39-42. PubMed PMID: 20642202.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - High polymorphism of the MBL2 gene in patients with atopic dermatitis. AU - Carréra,Matilde Campos, AU - Moura,Patrícia, AU - Crovella,Sergio, AU - de Souza,Paulo Roberto Eleutério, AU - de Alencar,Luiz Cláudio Arraes, AU - Sarinho,Emanuel, PY - 2010/7/21/entrez PY - 2010/7/21/pubmed PY - 2010/9/2/medline SP - 39 EP - 42 JF - Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology JO - Ann. Allergy Asthma Immunol. VL - 105 IS - 1 N2 - BACKGROUND: Low serum levels of mannose-binding lectin (MBL) are determined mainly by variant alleles of the MBL2 gene and it has been suggested that MBL may play a role in the susceptibility to atopic dermatitis (AD). OBJECTIVE: The aim was to investigate the difference of the frequency of MBL2 variant alleles in AD patients and in a group of individuals without AD, and associate the MBL2 alleles with AD severity. METHODS: MBL2 variant allele's frequency was investigated in 131 children with AD and 165 healthy children/adolescents matched by convenience. The severity of disease was graded according to the SCORing Atopic Dermatitis (SCORAD) index. The first exon variants were called "O" and the wild type "A". The variants in the promoter were H/L at -550 and X/Y at -221, determined by Real Time PCR. RESULTS: Children with AD had higher frequency of allele O and the genotypes related to low or deficient levels of MBL, when compared to the healthy group (p = 0.0012 and p < 0.001, respectively), but not with AD severity. CONCLUSION: Low or deficient MBL serum levels determined genetically may contribute to the predisposition for AD, but not for disease severity. SN - 1081-1206 UR - https://www.unboundmedicine.com/medline/citation/20642202/High_polymorphism_of_the_MBL2_gene_in_patients_with_atopic_dermatitis_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1081-1206(10)00386-8 DB - PRIME DP - Unbound Medicine ER -