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Tetrahydroxystilbene glucoside attenuates MPP+-induced apoptosis in PC12 cells by inhibiting ROS generation and modulating JNK activation.
Neurosci Lett. 2010 Oct 08; 483(1):1-5.NL

Abstract

It is known that oxidative stress plays a major role in the progression of Parkinson's disease (PD). Previous studies have suggested that 2,3,5,4'-tetrahydroxystilbene-2-O-beta-D-glucoside (TSG), an active component extracted from a traditional Chinese herb Polygonum multiflorum Thunb., has significant antioxidant and free radical-scavenging activities. This is the first study that investigated the protective effects of TSG against MPP(+)-induced apoptosis in PC12 cells and determined the underlying mechanism. The results showed that incubation of PC12 cells with TSG before exposing them to MPP(+) could significantly decrease cell viability loss and reverse cell apoptosis in a dose-dependent manner. The anti-apoptotic effects of TSG were probably mediated via the inhibition of ROS generation and modulation of JNK activation because TSG blocked ROS increase and JNK phosphorylation induced by MPP(+). Taken together, these results indicated that TSG may provide a useful therapeutic strategy for the treatment of neurodegenerative diseases such as PD.

Authors+Show Affiliations

Research Center of Traditional Chinese Medicine, Xijing Hospital, Fourth Military Medical University, No 17 Changlexi Road, Xi'an 710032, People's Republic of China.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

20643188

Citation

Li, Xiaobing, et al. "Tetrahydroxystilbene Glucoside Attenuates MPP+-induced Apoptosis in PC12 Cells By Inhibiting ROS Generation and Modulating JNK Activation." Neuroscience Letters, vol. 483, no. 1, 2010, pp. 1-5.
Li X, Li Y, Chen J, et al. Tetrahydroxystilbene glucoside attenuates MPP+-induced apoptosis in PC12 cells by inhibiting ROS generation and modulating JNK activation. Neurosci Lett. 2010;483(1):1-5.
Li, X., Li, Y., Chen, J., Sun, J., Li, X., Sun, X., & Kang, X. (2010). Tetrahydroxystilbene glucoside attenuates MPP+-induced apoptosis in PC12 cells by inhibiting ROS generation and modulating JNK activation. Neuroscience Letters, 483(1), 1-5. https://doi.org/10.1016/j.neulet.2010.07.027
Li X, et al. Tetrahydroxystilbene Glucoside Attenuates MPP+-induced Apoptosis in PC12 Cells By Inhibiting ROS Generation and Modulating JNK Activation. Neurosci Lett. 2010 Oct 8;483(1):1-5. PubMed PMID: 20643188.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Tetrahydroxystilbene glucoside attenuates MPP+-induced apoptosis in PC12 cells by inhibiting ROS generation and modulating JNK activation. AU - Li,Xiaobing, AU - Li,Yan, AU - Chen,Jianzong, AU - Sun,Jing, AU - Li,Xiaofeng, AU - Sun,Xin, AU - Kang,Xiaogang, Y1 - 2010/07/17/ PY - 2010/01/05/received PY - 2010/06/29/revised PY - 2010/07/13/accepted PY - 2010/7/21/entrez PY - 2010/7/21/pubmed PY - 2010/12/14/medline SP - 1 EP - 5 JF - Neuroscience letters JO - Neurosci Lett VL - 483 IS - 1 N2 - It is known that oxidative stress plays a major role in the progression of Parkinson's disease (PD). Previous studies have suggested that 2,3,5,4'-tetrahydroxystilbene-2-O-beta-D-glucoside (TSG), an active component extracted from a traditional Chinese herb Polygonum multiflorum Thunb., has significant antioxidant and free radical-scavenging activities. This is the first study that investigated the protective effects of TSG against MPP(+)-induced apoptosis in PC12 cells and determined the underlying mechanism. The results showed that incubation of PC12 cells with TSG before exposing them to MPP(+) could significantly decrease cell viability loss and reverse cell apoptosis in a dose-dependent manner. The anti-apoptotic effects of TSG were probably mediated via the inhibition of ROS generation and modulation of JNK activation because TSG blocked ROS increase and JNK phosphorylation induced by MPP(+). Taken together, these results indicated that TSG may provide a useful therapeutic strategy for the treatment of neurodegenerative diseases such as PD. SN - 1872-7972 UR - https://www.unboundmedicine.com/medline/citation/20643188/Tetrahydroxystilbene_glucoside_attenuates_MPP+_induced_apoptosis_in_PC12_cells_by_inhibiting_ROS_generation_and_modulating_JNK_activation_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0304-3940(10)00928-6 DB - PRIME DP - Unbound Medicine ER -