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Serotonin transporter gene moderates the development of emotional problems among children following bullying victimization.
J Am Acad Child Adolesc Psychiatry. 2010 Aug; 49(8):830-40.JA

Abstract

OBJECTIVE

Bullying is the act of intentionally and repeatedly causing harm to someone who has difficulty defending him- or herself, and is a relatively widespread school-age phenomenon. Being the victim of bullying is associated with a broad spectrum of emotional problems; however, not all children who are bullied go on to develop such problems.

METHOD

We tested the hypothesis that the relationship between bullying victimization and emotional problems was moderated by variation in the serotonin transporter (5-HTT) gene in 2,232 British children comprising the Environmental Risk (E-Risk) study cohort.

RESULTS

Our data supported the hypothesis that children's bullying victimization leads to their developing emotional problems, and that genetic variation in the 5-HTTLPR moderates this relationship. Specifically, frequently bullied children with the SS genotype were at greater risk for developing emotional problems at age 12 than were children with the SL or LL genotype. Furthermore, we demonstrated that this genetic moderation persisted (a) after controlling for children's previctimization emotional problems by assessing intraindividual change in problems between ages 5 and 12 years, and (b) after controlling for other risk factors shared by children growing up in the same family by comparing emotional problems in twins discordant for bullying victimization.

CONCLUSIONS

These findings are further evidence that the 5-HTTLPR moderates the risk of emotional disturbance after exposure to stressful events.

Authors+Show Affiliations

Department of Psychology and Neuroscience, Duke University, 2020 West Main Street, Suite 201, Box 104410, Durham, NC 27708, USA. karen.sugden@duke.eduNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Twin Study

Language

eng

PubMed ID

20643316

Citation

Sugden, Karen, et al. "Serotonin Transporter Gene Moderates the Development of Emotional Problems Among Children Following Bullying Victimization." Journal of the American Academy of Child and Adolescent Psychiatry, vol. 49, no. 8, 2010, pp. 830-40.
Sugden K, Arseneault L, Harrington H, et al. Serotonin transporter gene moderates the development of emotional problems among children following bullying victimization. J Am Acad Child Adolesc Psychiatry. 2010;49(8):830-40.
Sugden, K., Arseneault, L., Harrington, H., Moffitt, T. E., Williams, B., & Caspi, A. (2010). Serotonin transporter gene moderates the development of emotional problems among children following bullying victimization. Journal of the American Academy of Child and Adolescent Psychiatry, 49(8), 830-40. https://doi.org/10.1016/j.jaac.2010.01.024
Sugden K, et al. Serotonin Transporter Gene Moderates the Development of Emotional Problems Among Children Following Bullying Victimization. J Am Acad Child Adolesc Psychiatry. 2010;49(8):830-40. PubMed PMID: 20643316.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Serotonin transporter gene moderates the development of emotional problems among children following bullying victimization. AU - Sugden,Karen, AU - Arseneault,Louise, AU - Harrington,HonaLee, AU - Moffitt,Terrie E, AU - Williams,Benjamin, AU - Caspi,Avshalom, Y1 - 2010/05/13/ PY - 2009/08/14/received PY - 2010/01/28/revised PY - 2010/03/18/accepted PY - 2010/7/21/entrez PY - 2010/7/21/pubmed PY - 2010/12/29/medline SP - 830 EP - 40 JF - Journal of the American Academy of Child and Adolescent Psychiatry JO - J Am Acad Child Adolesc Psychiatry VL - 49 IS - 8 N2 - OBJECTIVE: Bullying is the act of intentionally and repeatedly causing harm to someone who has difficulty defending him- or herself, and is a relatively widespread school-age phenomenon. Being the victim of bullying is associated with a broad spectrum of emotional problems; however, not all children who are bullied go on to develop such problems. METHOD: We tested the hypothesis that the relationship between bullying victimization and emotional problems was moderated by variation in the serotonin transporter (5-HTT) gene in 2,232 British children comprising the Environmental Risk (E-Risk) study cohort. RESULTS: Our data supported the hypothesis that children's bullying victimization leads to their developing emotional problems, and that genetic variation in the 5-HTTLPR moderates this relationship. Specifically, frequently bullied children with the SS genotype were at greater risk for developing emotional problems at age 12 than were children with the SL or LL genotype. Furthermore, we demonstrated that this genetic moderation persisted (a) after controlling for children's previctimization emotional problems by assessing intraindividual change in problems between ages 5 and 12 years, and (b) after controlling for other risk factors shared by children growing up in the same family by comparing emotional problems in twins discordant for bullying victimization. CONCLUSIONS: These findings are further evidence that the 5-HTTLPR moderates the risk of emotional disturbance after exposure to stressful events. SN - 1527-5418 UR - https://www.unboundmedicine.com/medline/citation/20643316/Serotonin_transporter_gene_moderates_the_development_of_emotional_problems_among_children_following_bullying_victimization_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0890-8567(10)00284-4 DB - PRIME DP - Unbound Medicine ER -