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Aripiprazole in autism spectrum disorders and fragile X syndrome.
Neurotherapeutics. 2010 Jul; 7(3):258-63.N

Abstract

Autism spectrum disorders (ASDs) are childhood onset developmental disorders characterized by impairment of social skills and repetitive behavior, and also for classic autistic disorder, a significant impairment of communication. In addition to these core symptom domains, persons with ASDs frequently exhibit interfering behavioral symptoms, including irritability marked by aggression, self-injurious behavior, and severe tantrums. Aripiprazole is an atypical or newer generation antipsychotic with a unique mechanism of action impacting dopaminergic and serotonergic neurotransmission. The drug has been found efficacious for several indications, including most recently for use targeting irritability associated with autistic disorder in youth. Fragile X syndrome is the most common inherited cause of developmental disability and the most common known single gene cause of ASDs. As in idiopathic ASDs, irritable behavior is often exhibited by persons with fragile X syndrome. However, research to date in this disorder has not focused on this target symptom cluster. An initial pilot study has begun to assess the impact of aripiprazole on irritability in youth with fragile X syndrome.

Authors+Show Affiliations

Department of Psychiatry, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA. crericks@iupui.eduNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

20643378

Citation

Erickson, Craig A., et al. "Aripiprazole in Autism Spectrum Disorders and Fragile X Syndrome." Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics, vol. 7, no. 3, 2010, pp. 258-63.
Erickson CA, Stigler KA, Posey DJ, et al. Aripiprazole in autism spectrum disorders and fragile X syndrome. Neurotherapeutics. 2010;7(3):258-63.
Erickson, C. A., Stigler, K. A., Posey, D. J., & McDougle, C. J. (2010). Aripiprazole in autism spectrum disorders and fragile X syndrome. Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics, 7(3), 258-63. https://doi.org/10.1016/j.nurt.2010.04.001
Erickson CA, et al. Aripiprazole in Autism Spectrum Disorders and Fragile X Syndrome. Neurotherapeutics. 2010;7(3):258-63. PubMed PMID: 20643378.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Aripiprazole in autism spectrum disorders and fragile X syndrome. AU - Erickson,Craig A, AU - Stigler,Kimberly A, AU - Posey,David J, AU - McDougle,Christopher J, PY - 2010/02/15/received PY - 2010/04/09/revised PY - 2010/04/30/accepted PY - 2010/7/21/entrez PY - 2010/7/21/pubmed PY - 2010/10/26/medline SP - 258 EP - 63 JF - Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics JO - Neurotherapeutics VL - 7 IS - 3 N2 - Autism spectrum disorders (ASDs) are childhood onset developmental disorders characterized by impairment of social skills and repetitive behavior, and also for classic autistic disorder, a significant impairment of communication. In addition to these core symptom domains, persons with ASDs frequently exhibit interfering behavioral symptoms, including irritability marked by aggression, self-injurious behavior, and severe tantrums. Aripiprazole is an atypical or newer generation antipsychotic with a unique mechanism of action impacting dopaminergic and serotonergic neurotransmission. The drug has been found efficacious for several indications, including most recently for use targeting irritability associated with autistic disorder in youth. Fragile X syndrome is the most common inherited cause of developmental disability and the most common known single gene cause of ASDs. As in idiopathic ASDs, irritable behavior is often exhibited by persons with fragile X syndrome. However, research to date in this disorder has not focused on this target symptom cluster. An initial pilot study has begun to assess the impact of aripiprazole on irritability in youth with fragile X syndrome. SN - 1878-7479 UR - https://www.unboundmedicine.com/medline/citation/20643378/Aripiprazole_in_autism_spectrum_disorders_and_fragile_X_syndrome_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1933-7213(10)00042-5 DB - PRIME DP - Unbound Medicine ER -