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Antidiabetic, antihyperlipidemic and antioxidant activities of methanolic extract of Amaranthus viridis Linn in alloxan induced diabetic rats.
Exp Toxicol Pathol. 2012 Jan; 64(1-2):75-9.ET

Abstract

The aim of this study was to investigate the antidiabetic, antihyperlipidemic and antioxidant activities of methanolic extract of whole plant of Amaranthus viridis (MEAV) in alloxan (ALX) induced diabetic rats. Diabetes was confirmed after 5 days of single intraperitoneal injection of ALX (140 mg/kg) in albino Wister rats. MEAV (200 and 400 mg/kg) and glibenclamide (10 mg/kg, p.o.) orally administered daily for 15 days, blood was withdrawn for glucose determination on 0, 1, 10 and 15 days respectively. On the 15th day, overnight fasted rats were sacrificed and blood was collected for the determination of high density lipoproteins cholesterol (HDL-C), low density lipoprotein cholesterol (LDL-C), very low density lipoprotein cholesterol (VLDL-C), total cholesterol (TC), total glycerides (TG) and total proteins (TP). For in vivo antioxidant activity of MEAV, liver tissues were homogenized and the assay of lipid peroxidation and was measured as Malondialdehyde (MDA), glutathione (GSH), catalase (CAT) and total thiols (TT) were performed in control, ALX and MEAV treated rats. MEAV at doses of 200 and 400 mg/kg showed significant reduction is blood glucose, lipid profiles and significant improvement in MDA, GSH, CAT and TT when compared to diabetic control group. In vitro α-amylase inhibition activity of MEAV was also studied. We concluded that MEAV possess antidiabetic, antihyperlipidemic and antioxidant activities.

Authors+Show Affiliations

Department of Pharmacognosy, Sri K.V. College of Pharmacy, M.G. Road, Chickballapur, Karnataka 562101, India. ashok4vani@gmail.comNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

20643534

Citation

Ashok Kumar, B S., et al. "Antidiabetic, Antihyperlipidemic and Antioxidant Activities of Methanolic Extract of Amaranthus Viridis Linn in Alloxan Induced Diabetic Rats." Experimental and Toxicologic Pathology : Official Journal of the Gesellschaft Fur Toxikologische Pathologie, vol. 64, no. 1-2, 2012, pp. 75-9.
Ashok Kumar BS, Lakshman K, Jayaveea KN, et al. Antidiabetic, antihyperlipidemic and antioxidant activities of methanolic extract of Amaranthus viridis Linn in alloxan induced diabetic rats. Exp Toxicol Pathol. 2012;64(1-2):75-9.
Ashok Kumar, B. S., Lakshman, K., Jayaveea, K. N., Sheshadri Shekar, D., Saleemulla Khan, ., Thippeswamy, B. S., & Veerapur, V. P. (2012). Antidiabetic, antihyperlipidemic and antioxidant activities of methanolic extract of Amaranthus viridis Linn in alloxan induced diabetic rats. Experimental and Toxicologic Pathology : Official Journal of the Gesellschaft Fur Toxikologische Pathologie, 64(1-2), 75-9. https://doi.org/10.1016/j.etp.2010.06.009
Ashok Kumar BS, et al. Antidiabetic, Antihyperlipidemic and Antioxidant Activities of Methanolic Extract of Amaranthus Viridis Linn in Alloxan Induced Diabetic Rats. Exp Toxicol Pathol. 2012;64(1-2):75-9. PubMed PMID: 20643534.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Antidiabetic, antihyperlipidemic and antioxidant activities of methanolic extract of Amaranthus viridis Linn in alloxan induced diabetic rats. AU - Ashok Kumar,B S, AU - Lakshman,K, AU - Jayaveea,K N, AU - Sheshadri Shekar,D, AU - Saleemulla Khan,, AU - Thippeswamy,B S, AU - Veerapur,Veeresh P, Y1 - 2010/07/18/ PY - 2010/03/19/received PY - 2010/06/02/revised PY - 2010/06/11/accepted PY - 2010/7/21/entrez PY - 2010/7/21/pubmed PY - 2012/5/15/medline SP - 75 EP - 9 JF - Experimental and toxicologic pathology : official journal of the Gesellschaft fur Toxikologische Pathologie JO - Exp Toxicol Pathol VL - 64 IS - 1-2 N2 - The aim of this study was to investigate the antidiabetic, antihyperlipidemic and antioxidant activities of methanolic extract of whole plant of Amaranthus viridis (MEAV) in alloxan (ALX) induced diabetic rats. Diabetes was confirmed after 5 days of single intraperitoneal injection of ALX (140 mg/kg) in albino Wister rats. MEAV (200 and 400 mg/kg) and glibenclamide (10 mg/kg, p.o.) orally administered daily for 15 days, blood was withdrawn for glucose determination on 0, 1, 10 and 15 days respectively. On the 15th day, overnight fasted rats were sacrificed and blood was collected for the determination of high density lipoproteins cholesterol (HDL-C), low density lipoprotein cholesterol (LDL-C), very low density lipoprotein cholesterol (VLDL-C), total cholesterol (TC), total glycerides (TG) and total proteins (TP). For in vivo antioxidant activity of MEAV, liver tissues were homogenized and the assay of lipid peroxidation and was measured as Malondialdehyde (MDA), glutathione (GSH), catalase (CAT) and total thiols (TT) were performed in control, ALX and MEAV treated rats. MEAV at doses of 200 and 400 mg/kg showed significant reduction is blood glucose, lipid profiles and significant improvement in MDA, GSH, CAT and TT when compared to diabetic control group. In vitro α-amylase inhibition activity of MEAV was also studied. We concluded that MEAV possess antidiabetic, antihyperlipidemic and antioxidant activities. SN - 1618-1433 UR - https://www.unboundmedicine.com/medline/citation/20643534/Antidiabetic_antihyperlipidemic_and_antioxidant_activities_of_methanolic_extract_of_Amaranthus_viridis_Linn_in_alloxan_induced_diabetic_rats_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0940-2993(10)00108-9 DB - PRIME DP - Unbound Medicine ER -