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Staphylococcus aureus carriage in the anterior nares of close contacts of patients with atopic dermatitis.
Arch Dermatol. 2010 Jul; 146(7):748-52.AD

Abstract

OBJECTIVE

To study the prevalence of Staphylococcus aureus colonization in close contacts of patients with atopic dermatitis (AD) and the influence on AD severity.

DESIGN

Prospective case-control study.

SETTING

Pediatric dermatology clinic in a Hong Kong university hospital. Patients We recruited 211 subjects prospectively, including 50 AD patients, 50 non-AD control subjects, 60 close contacts of AD patients, and 51 close contacts of controls. Intervention Nasal swabs and skin swabs were taken. Severity of AD was assessed using the SCORAD (Scoring Atopic Dermatitis) index.

MAIN OUTCOME MEASURES

The prevalence of S aureus colonization in the close contacts of AD patients was compared with that of the close contacts of non-AD controls. Between-group differences were assessed, where appropriate, by unpaired t test or Pearson chi(2) test. Multivariate logistic regression using the forward stepwise method was performed to identify independent predictors of severe AD. A probability value of P < .05 was considered statistically significant.

RESULTS

Significantly more nasal carriers of S aureus were found among the close contacts of AD patients (14 of 60 [23%]) than among the close contacts of non-AD controls (4 of 51 [8%] [P = .03]). The difference was still significant after the exclusion of the AD patients' close contacts who also had AD (24% vs 8% [P = .03]). By multivariate analysis, only skin colonization of S aureus was independently associated with severe AD (odds ratio, 17.0; 95% confidence interval, 1.60-181.1 [P = .02]).

CONCLUSIONS

Anterior nares of close contacts of AD patients are reservoirs of S aureus. The presence of S aureus carriers among close contacts does not predict AD severity. Skin colonization is associated with severe AD.

Authors+Show Affiliations

Department of Medicine and Therapeutics, Ninth Floor, Clinical Science Building, Prince of Wales Hospital, Shatin, NT, Hong Kong SAR. monachiu@gmail.comNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

20644035

Citation

Chiu, Lai Shan, et al. "Staphylococcus Aureus Carriage in the Anterior Nares of Close Contacts of Patients With Atopic Dermatitis." Archives of Dermatology, vol. 146, no. 7, 2010, pp. 748-52.
Chiu LS, Chow VC, Ling JM, et al. Staphylococcus aureus carriage in the anterior nares of close contacts of patients with atopic dermatitis. Arch Dermatol. 2010;146(7):748-52.
Chiu, L. S., Chow, V. C., Ling, J. M., & Hon, K. L. (2010). Staphylococcus aureus carriage in the anterior nares of close contacts of patients with atopic dermatitis. Archives of Dermatology, 146(7), 748-52. https://doi.org/10.1001/archdermatol.2010.129
Chiu LS, et al. Staphylococcus Aureus Carriage in the Anterior Nares of Close Contacts of Patients With Atopic Dermatitis. Arch Dermatol. 2010;146(7):748-52. PubMed PMID: 20644035.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Staphylococcus aureus carriage in the anterior nares of close contacts of patients with atopic dermatitis. AU - Chiu,Lai Shan, AU - Chow,Viola Chi Ying, AU - Ling,Julia Mei Lun, AU - Hon,Kam Lun, PY - 2010/7/21/entrez PY - 2010/7/21/pubmed PY - 2010/9/23/medline SP - 748 EP - 52 JF - Archives of dermatology JO - Arch Dermatol VL - 146 IS - 7 N2 - OBJECTIVE: To study the prevalence of Staphylococcus aureus colonization in close contacts of patients with atopic dermatitis (AD) and the influence on AD severity. DESIGN: Prospective case-control study. SETTING: Pediatric dermatology clinic in a Hong Kong university hospital. Patients We recruited 211 subjects prospectively, including 50 AD patients, 50 non-AD control subjects, 60 close contacts of AD patients, and 51 close contacts of controls. Intervention Nasal swabs and skin swabs were taken. Severity of AD was assessed using the SCORAD (Scoring Atopic Dermatitis) index. MAIN OUTCOME MEASURES: The prevalence of S aureus colonization in the close contacts of AD patients was compared with that of the close contacts of non-AD controls. Between-group differences were assessed, where appropriate, by unpaired t test or Pearson chi(2) test. Multivariate logistic regression using the forward stepwise method was performed to identify independent predictors of severe AD. A probability value of P < .05 was considered statistically significant. RESULTS: Significantly more nasal carriers of S aureus were found among the close contacts of AD patients (14 of 60 [23%]) than among the close contacts of non-AD controls (4 of 51 [8%] [P = .03]). The difference was still significant after the exclusion of the AD patients' close contacts who also had AD (24% vs 8% [P = .03]). By multivariate analysis, only skin colonization of S aureus was independently associated with severe AD (odds ratio, 17.0; 95% confidence interval, 1.60-181.1 [P = .02]). CONCLUSIONS: Anterior nares of close contacts of AD patients are reservoirs of S aureus. The presence of S aureus carriers among close contacts does not predict AD severity. Skin colonization is associated with severe AD. SN - 1538-3652 UR - https://www.unboundmedicine.com/medline/citation/20644035/Staphylococcus_aureus_carriage_in_the_anterior_nares_of_close_contacts_of_patients_with_atopic_dermatitis_ DB - PRIME DP - Unbound Medicine ER -