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High serum uric acid increases the risk for nonalcoholic Fatty liver disease: a prospective observational study.
PLoS One. 2010 Jul 14; 5(7):e11578.Plos

Abstract

Nonalcoholic fatty liver disease (NAFLD) is a common form of chronic liver disease, and serum uric acid is observed to be significantly elevated in NAFLD patients. However, whether this elevation is causal, a bystander, or a consequence of NAFLD remains unclear. We performed a population-based prospective study among the employees of Zhenhai Refining & Chemical Company Ltd., Ningbo, China to investigate whether the elevation of serum uric acid has a casual role for NAFLD. A total of 6890 initially NAFLD-free subjects were followed up for 3 years. Overall, 11.80% (813/6890) subjects developed NAFLD over 3 years of follow-up. The cumulative incidence of NAFLD increased with progressively higher baseline serum uric acid levels (the cumulative incidence was 7.2%, 9.5%, 11.5%, 13.8%, and 17.2% in quintile 1, quintile 2, 3, 4 and 5, respectively; P value for trend <0.001). Cox proportional hazards regression analyses showed that serum uric acid levels were independently and positively associated with the risk for incident NAFLD; the age-, gender- and metabolic syndrome adjusted hazard ratio (95% CI) for the subjects in quintile 2, 3, 4 and 5 versus quintile 1 was 1.18 (0.91-1.54), 1.32 (1.03-1.70), 1.39 (1.09-1.78) and 1.50 (1.18-1.92), respectively. Taken together, our prospective observational study showed that elevation of serum uric acid levels independently predicts increase risk for incident NAFLD.

Authors+Show Affiliations

Department of Gastroenterology, the First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, China.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

20644649

Citation

Xu, Chengfu, et al. "High Serum Uric Acid Increases the Risk for Nonalcoholic Fatty Liver Disease: a Prospective Observational Study." PloS One, vol. 5, no. 7, 2010, pp. e11578.
Xu C, Yu C, Xu L, et al. High serum uric acid increases the risk for nonalcoholic Fatty liver disease: a prospective observational study. PLoS One. 2010;5(7):e11578.
Xu, C., Yu, C., Xu, L., Miao, M., & Li, Y. (2010). High serum uric acid increases the risk for nonalcoholic Fatty liver disease: a prospective observational study. PloS One, 5(7), e11578. https://doi.org/10.1371/journal.pone.0011578
Xu C, et al. High Serum Uric Acid Increases the Risk for Nonalcoholic Fatty Liver Disease: a Prospective Observational Study. PLoS One. 2010 Jul 14;5(7):e11578. PubMed PMID: 20644649.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - High serum uric acid increases the risk for nonalcoholic Fatty liver disease: a prospective observational study. AU - Xu,Chengfu, AU - Yu,Chaohui, AU - Xu,Lei, AU - Miao,Min, AU - Li,Youming, Y1 - 2010/07/14/ PY - 2010/04/01/received PY - 2010/06/22/accepted PY - 2010/7/21/entrez PY - 2010/7/21/pubmed PY - 2010/10/29/medline SP - e11578 EP - e11578 JF - PloS one JO - PLoS One VL - 5 IS - 7 N2 - Nonalcoholic fatty liver disease (NAFLD) is a common form of chronic liver disease, and serum uric acid is observed to be significantly elevated in NAFLD patients. However, whether this elevation is causal, a bystander, or a consequence of NAFLD remains unclear. We performed a population-based prospective study among the employees of Zhenhai Refining & Chemical Company Ltd., Ningbo, China to investigate whether the elevation of serum uric acid has a casual role for NAFLD. A total of 6890 initially NAFLD-free subjects were followed up for 3 years. Overall, 11.80% (813/6890) subjects developed NAFLD over 3 years of follow-up. The cumulative incidence of NAFLD increased with progressively higher baseline serum uric acid levels (the cumulative incidence was 7.2%, 9.5%, 11.5%, 13.8%, and 17.2% in quintile 1, quintile 2, 3, 4 and 5, respectively; P value for trend <0.001). Cox proportional hazards regression analyses showed that serum uric acid levels were independently and positively associated with the risk for incident NAFLD; the age-, gender- and metabolic syndrome adjusted hazard ratio (95% CI) for the subjects in quintile 2, 3, 4 and 5 versus quintile 1 was 1.18 (0.91-1.54), 1.32 (1.03-1.70), 1.39 (1.09-1.78) and 1.50 (1.18-1.92), respectively. Taken together, our prospective observational study showed that elevation of serum uric acid levels independently predicts increase risk for incident NAFLD. SN - 1932-6203 UR - https://www.unboundmedicine.com/medline/citation/20644649/High_serum_uric_acid_increases_the_risk_for_nonalcoholic_Fatty_liver_disease:_a_prospective_observational_study_ L2 - https://dx.plos.org/10.1371/journal.pone.0011578 DB - PRIME DP - Unbound Medicine ER -