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The incidence of gross proteinuria in people with insulin-dependent diabetes mellitus.
Arch Intern Med 1991; 151(7):1344-8AI

Abstract

Epidemiologic data on the incidence of gross proteinuria in people with diabetes are important in medical counseling, in projecting estimates of needs and costs of health care, and for developing approaches to prevent renal complications. We performed a population-based incidence study in southern Wisconsin of insulin-taking diabetic persons diagnosed before 30 years of age. The presence of gross proteinuria (greater than or equal to 0.30 g/L) was determined by means of a reagent strip. The incidence of proteinuria in a 4-year interval was 14.4% (95% confidence interval, 11.7% to 17.0%). The relative risk of developing proteinuria after 4 years for those with glycosylated hemoglobin levels in the highest quartile compared with those in the lowest quartile was 3.0 (95% confidence interval, 1.6 to 5.3). The incidence of proteinuria was also associated with higher diastolic blood pressure, being male, taking more insulin, and having more severe retinopathy at the baseline examination. The relationship between glycosylated hemoglobin level and the incidence of proteinuria was significant even after controlling for these other risk variables. These data suggest that hyperglycemia, as measured by glycosylated hemoglobin level, is a significant risk factor for the development of gross proteinuria.

Authors+Show Affiliations

Department of Ophthalmology, University of Wisconsin Medical School, Madison.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

2064485

Citation

Klein, R, et al. "The Incidence of Gross Proteinuria in People With Insulin-dependent Diabetes Mellitus." Archives of Internal Medicine, vol. 151, no. 7, 1991, pp. 1344-8.
Klein R, Klein BE, Moss SE. The incidence of gross proteinuria in people with insulin-dependent diabetes mellitus. Arch Intern Med. 1991;151(7):1344-8.
Klein, R., Klein, B. E., & Moss, S. E. (1991). The incidence of gross proteinuria in people with insulin-dependent diabetes mellitus. Archives of Internal Medicine, 151(7), pp. 1344-8.
Klein R, Klein BE, Moss SE. The Incidence of Gross Proteinuria in People With Insulin-dependent Diabetes Mellitus. Arch Intern Med. 1991;151(7):1344-8. PubMed PMID: 2064485.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The incidence of gross proteinuria in people with insulin-dependent diabetes mellitus. AU - Klein,R, AU - Klein,B E, AU - Moss,S E, PY - 1991/7/1/pubmed PY - 1991/7/1/medline PY - 1991/7/1/entrez SP - 1344 EP - 8 JF - Archives of internal medicine JO - Arch. Intern. Med. VL - 151 IS - 7 N2 - Epidemiologic data on the incidence of gross proteinuria in people with diabetes are important in medical counseling, in projecting estimates of needs and costs of health care, and for developing approaches to prevent renal complications. We performed a population-based incidence study in southern Wisconsin of insulin-taking diabetic persons diagnosed before 30 years of age. The presence of gross proteinuria (greater than or equal to 0.30 g/L) was determined by means of a reagent strip. The incidence of proteinuria in a 4-year interval was 14.4% (95% confidence interval, 11.7% to 17.0%). The relative risk of developing proteinuria after 4 years for those with glycosylated hemoglobin levels in the highest quartile compared with those in the lowest quartile was 3.0 (95% confidence interval, 1.6 to 5.3). The incidence of proteinuria was also associated with higher diastolic blood pressure, being male, taking more insulin, and having more severe retinopathy at the baseline examination. The relationship between glycosylated hemoglobin level and the incidence of proteinuria was significant even after controlling for these other risk variables. These data suggest that hyperglycemia, as measured by glycosylated hemoglobin level, is a significant risk factor for the development of gross proteinuria. SN - 0003-9926 UR - https://www.unboundmedicine.com/medline/citation/2064485/The_incidence_of_gross_proteinuria_in_people_with_insulin_dependent_diabetes_mellitus_ L2 - https://jamanetwork.com/journals/jamainternalmedicine/fullarticle/vol/151/pg/1344 DB - PRIME DP - Unbound Medicine ER -