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The development of antimicrobial resistance due to the antibiotic treatment of acne vulgaris: a review.
J Drugs Dermatol. 2010 Jun; 9(6):655-64.JD

Abstract

OBJECTIVE

To review recent studies on the use of antibiotics in acne vulgaris which provide insight into the development of antimicrobial resistance.

DATA SOURCES

Sources for this article were identified by searching the English literature by Medline for the period 1960 to March 2009.

STUDY SELECTION

The following relevant terms were used: acne, acne vulgaris, acne and antibiotic therapy, acne and antimicrobial resistance, acne and resistance mechanisms, acne and systemic infections, acne and antibiotic resistance and coagulase-negative Staphylococcus aureus (S. aureus), acne and antibiotic resistance and upper respiratory infection.

DATA SYNTHESIS

Both correct and incorrect use of antibiotics for acne vulgaris can promote antimicrobial resistance. The development of this resistance is promoted by several factors, including antibiotic monotherapy, long-term administration of antibiotics, indiscriminate use outside their strict indications, dosing below the recommended levels, and the administration of antibiotics without concurrent benzoyl peroxide and/or topical retinoids.

CONCLUSION

Long-term use of antibiotics in the treatment of acne vulgaris can lead to antimicrobial resistance with serious and intractable problems not limited to Propionibacterium acnes (P. acnes), the skin and acne vulgaris themselves, but also to other bacterial species, with systemic consequences. These findings suggest that antibiotics should be prescribed in combination with benzoyl peroxide and/or topical retinoids and be limited to a maximum of several months.

Authors+Show Affiliations

Department of Dermatology, State University of NewYork, Downstate Medical Center, Brooklyn, NY, USA.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

20645527

Citation

Patel, Mital, et al. "The Development of Antimicrobial Resistance Due to the Antibiotic Treatment of Acne Vulgaris: a Review." Journal of Drugs in Dermatology : JDD, vol. 9, no. 6, 2010, pp. 655-64.
Patel M, Bowe WP, Heughebaert C, et al. The development of antimicrobial resistance due to the antibiotic treatment of acne vulgaris: a review. J Drugs Dermatol. 2010;9(6):655-64.
Patel, M., Bowe, W. P., Heughebaert, C., & Shalita, A. R. (2010). The development of antimicrobial resistance due to the antibiotic treatment of acne vulgaris: a review. Journal of Drugs in Dermatology : JDD, 9(6), 655-64.
Patel M, et al. The Development of Antimicrobial Resistance Due to the Antibiotic Treatment of Acne Vulgaris: a Review. J Drugs Dermatol. 2010;9(6):655-64. PubMed PMID: 20645527.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The development of antimicrobial resistance due to the antibiotic treatment of acne vulgaris: a review. AU - Patel,Mital, AU - Bowe,Whitney P, AU - Heughebaert,Carol, AU - Shalita,Alan R, PY - 2010/7/22/entrez PY - 2010/7/22/pubmed PY - 2010/8/18/medline SP - 655 EP - 64 JF - Journal of drugs in dermatology : JDD JO - J Drugs Dermatol VL - 9 IS - 6 N2 - OBJECTIVE: To review recent studies on the use of antibiotics in acne vulgaris which provide insight into the development of antimicrobial resistance. DATA SOURCES: Sources for this article were identified by searching the English literature by Medline for the period 1960 to March 2009. STUDY SELECTION: The following relevant terms were used: acne, acne vulgaris, acne and antibiotic therapy, acne and antimicrobial resistance, acne and resistance mechanisms, acne and systemic infections, acne and antibiotic resistance and coagulase-negative Staphylococcus aureus (S. aureus), acne and antibiotic resistance and upper respiratory infection. DATA SYNTHESIS: Both correct and incorrect use of antibiotics for acne vulgaris can promote antimicrobial resistance. The development of this resistance is promoted by several factors, including antibiotic monotherapy, long-term administration of antibiotics, indiscriminate use outside their strict indications, dosing below the recommended levels, and the administration of antibiotics without concurrent benzoyl peroxide and/or topical retinoids. CONCLUSION: Long-term use of antibiotics in the treatment of acne vulgaris can lead to antimicrobial resistance with serious and intractable problems not limited to Propionibacterium acnes (P. acnes), the skin and acne vulgaris themselves, but also to other bacterial species, with systemic consequences. These findings suggest that antibiotics should be prescribed in combination with benzoyl peroxide and/or topical retinoids and be limited to a maximum of several months. SN - 1545-9616 UR - https://www.unboundmedicine.com/medline/citation/20645527/The_development_of_antimicrobial_resistance_due_to_the_antibiotic_treatment_of_acne_vulgaris:_a_review_ L2 - https://medlineplus.gov/acne.html DB - PRIME DP - Unbound Medicine ER -