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Anti-inflammatory, antinociceptive and antipyretic properties of the aqueous extract of Clematis brachiata leaf in male rats.
Pharm Biol. 2010 Jun; 48(6):682-9.PB

Abstract

Clematis brachiata Thunb. (Ranunculaceae) is used as a folk remedy for the treatment of pain, fever and inflammatory ailments. Aqueous extract of Clematis brachiata leaf was screened for its phytochemical constituents. The anti-inflammatory investigations were carried out using carrageenan and histamine-induced edema models; acetic acid writhing, formalin-induced pain and tail immersion models were used to evaluate antinociceptive activity while a Brewer's yeast-induced hyperthermia model was employed for the antipyretic experiment. Phytochemical screening of the extract revealed the presence of tannins, saponins, flavonoids and cardiac glycosides. The extract at 100, 200 and 400 mg/kg body weight significantly (P<0.05) reduced the edema paw volumes induced by carrageenan and histamine with the 400 mg/kg body weight extract being the most potent. On the antinociceptive front, while the extract reduced the writhing caused by acetic acid and the number of licks induced by formalin in a dose dependent manner, the increase in the reaction time by the extract in the tail immersion model was not dose-dependent. Again, there was significant (P<0.05) lowering of the Brewer's yeast-provoked elevated body temperature. The results suggest that the aqueous extract of Clematis brachiata leaves can be employed in the management of inflammation, pain and fever. These activities may be due in part to the flavonoid content of the extract.

Authors+Show Affiliations

Center for Phytomedicine Research, Department of Botany, University of Fort Hare, Alice, South Africa.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

20645742

Citation

Mostafa, Mohammad, et al. "Anti-inflammatory, Antinociceptive and Antipyretic Properties of the Aqueous Extract of Clematis Brachiata Leaf in Male Rats." Pharmaceutical Biology, vol. 48, no. 6, 2010, pp. 682-9.
Mostafa M, Appidi JR, Yakubu MT, et al. Anti-inflammatory, antinociceptive and antipyretic properties of the aqueous extract of Clematis brachiata leaf in male rats. Pharm Biol. 2010;48(6):682-9.
Mostafa, M., Appidi, J. R., Yakubu, M. T., & Afolayan, A. J. (2010). Anti-inflammatory, antinociceptive and antipyretic properties of the aqueous extract of Clematis brachiata leaf in male rats. Pharmaceutical Biology, 48(6), 682-9. https://doi.org/10.3109/13880200903257966
Mostafa M, et al. Anti-inflammatory, Antinociceptive and Antipyretic Properties of the Aqueous Extract of Clematis Brachiata Leaf in Male Rats. Pharm Biol. 2010;48(6):682-9. PubMed PMID: 20645742.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Anti-inflammatory, antinociceptive and antipyretic properties of the aqueous extract of Clematis brachiata leaf in male rats. AU - Mostafa,Mohammad, AU - Appidi,Jaipal R, AU - Yakubu,Musa T, AU - Afolayan,Anthony J, PY - 2010/7/22/entrez PY - 2010/7/22/pubmed PY - 2010/10/28/medline SP - 682 EP - 9 JF - Pharmaceutical biology JO - Pharm Biol VL - 48 IS - 6 N2 - Clematis brachiata Thunb. (Ranunculaceae) is used as a folk remedy for the treatment of pain, fever and inflammatory ailments. Aqueous extract of Clematis brachiata leaf was screened for its phytochemical constituents. The anti-inflammatory investigations were carried out using carrageenan and histamine-induced edema models; acetic acid writhing, formalin-induced pain and tail immersion models were used to evaluate antinociceptive activity while a Brewer's yeast-induced hyperthermia model was employed for the antipyretic experiment. Phytochemical screening of the extract revealed the presence of tannins, saponins, flavonoids and cardiac glycosides. The extract at 100, 200 and 400 mg/kg body weight significantly (P<0.05) reduced the edema paw volumes induced by carrageenan and histamine with the 400 mg/kg body weight extract being the most potent. On the antinociceptive front, while the extract reduced the writhing caused by acetic acid and the number of licks induced by formalin in a dose dependent manner, the increase in the reaction time by the extract in the tail immersion model was not dose-dependent. Again, there was significant (P<0.05) lowering of the Brewer's yeast-provoked elevated body temperature. The results suggest that the aqueous extract of Clematis brachiata leaves can be employed in the management of inflammation, pain and fever. These activities may be due in part to the flavonoid content of the extract. SN - 1744-5116 UR - https://www.unboundmedicine.com/medline/citation/20645742/Anti_inflammatory_antinociceptive_and_antipyretic_properties_of_the_aqueous_extract_of_Clematis_brachiata_leaf_in_male_rats_ L2 - http://www.tandfonline.com/doi/full/10.3109/13880200903257966 DB - PRIME DP - Unbound Medicine ER -