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Hepatoprotective activity of Stereospermum suaveolens against CCl4-induced liver damage in albino rats.
Pharm Biol. 2010 May; 48(5):524-8.PB

Abstract

The present study aims to evaluate the hepatoprotective activity of Stereospermum suaveolens DC (Bignoniaceae). Hepatoprotective activity is studied by carbon tetrachloride (CCl(4))-induced liver damage in albino rats. The degree of protection in this activity has been measured by using biochemical parameters such as serum glutamate oxaloacetate transaminase (SGOT), serum glutamate pyruvate transaminase (SGPT), alkaline phosphatase (ALP), total bilirubin, LDL-cholesterol and SOD, CAT, GSH, total thiols, NO, and lipid peroxidation in liver tissue homogenate. The results suggest that the methanol stem bark extract of Stereospermum suaveolens at the doses 125, 250, and 500 mg/kg and reference standard Liv-52 treated group produced significant (p <0.001) hepatoprotection against CCl(4)-induced liver damage by decreasing the activities of serum enzymes, bilirubin and lipid peroxidation. The extract significantly (p <0.001) increased levels of SOD, CAT, GSH and total thiols, as compared to control group. Histopathological studies further substantiate the protective effect of the extract. It was concluded that methanol stem bark extract of Stereospermum suaveolens showed effective hepatoprotective activity.

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Authors+Show Affiliations

Chandrashekhar VM
Department of Pharmacology, Hanagal Shri Kumareshwar College of Pharmacy, B.V.V.S. Campus, Bagalkot, Karnataka, India. chandupharm@yahoo.com
Muchandi AA
No affiliation info available
Sudi SV
No affiliation info available
Ganapty S
No affiliation info available

MeSH

AnimalsBignoniaceaeCarbon Tetrachloride PoisoningChemical and Drug Induced Liver InjuryFemaleMaleMicePlant ExtractsProtective AgentsRandom AllocationRatsRats, Wistar

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

20645794

Citation

Chandrashekhar, V M., et al. "Hepatoprotective Activity of Stereospermum Suaveolens Against CCl4-induced Liver Damage in Albino Rats." Pharmaceutical Biology, vol. 48, no. 5, 2010, pp. 524-8.
Chandrashekhar VM, Muchandi AA, Sudi SV, et al. Hepatoprotective activity of Stereospermum suaveolens against CCl4-induced liver damage in albino rats. Pharm Biol. 2010;48(5):524-8.
Chandrashekhar, V. M., Muchandi, A. A., Sudi, S. V., & Ganapty, S. (2010). Hepatoprotective activity of Stereospermum suaveolens against CCl4-induced liver damage in albino rats. Pharmaceutical Biology, 48(5), 524-8. https://doi.org/10.3109/13880200903173601
Chandrashekhar VM, et al. Hepatoprotective Activity of Stereospermum Suaveolens Against CCl4-induced Liver Damage in Albino Rats. Pharm Biol. 2010;48(5):524-8. PubMed PMID: 20645794.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Hepatoprotective activity of Stereospermum suaveolens against CCl4-induced liver damage in albino rats. AU - Chandrashekhar,V M, AU - Muchandi,Ashok A, AU - Sudi,Sarasvathi V, AU - Ganapty,Seru, PY - 2010/7/22/entrez PY - 2010/7/22/pubmed PY - 2011/4/26/medline SP - 524 EP - 8 JF - Pharmaceutical biology JO - Pharm Biol VL - 48 IS - 5 N2 - The present study aims to evaluate the hepatoprotective activity of Stereospermum suaveolens DC (Bignoniaceae). Hepatoprotective activity is studied by carbon tetrachloride (CCl(4))-induced liver damage in albino rats. The degree of protection in this activity has been measured by using biochemical parameters such as serum glutamate oxaloacetate transaminase (SGOT), serum glutamate pyruvate transaminase (SGPT), alkaline phosphatase (ALP), total bilirubin, LDL-cholesterol and SOD, CAT, GSH, total thiols, NO, and lipid peroxidation in liver tissue homogenate. The results suggest that the methanol stem bark extract of Stereospermum suaveolens at the doses 125, 250, and 500 mg/kg and reference standard Liv-52 treated group produced significant (p <0.001) hepatoprotection against CCl(4)-induced liver damage by decreasing the activities of serum enzymes, bilirubin and lipid peroxidation. The extract significantly (p <0.001) increased levels of SOD, CAT, GSH and total thiols, as compared to control group. Histopathological studies further substantiate the protective effect of the extract. It was concluded that methanol stem bark extract of Stereospermum suaveolens showed effective hepatoprotective activity. SN - 1744-5116 UR - https://www.unboundmedicine.com/medline/citation/20645794/Hepatoprotective_activity_of_Stereospermum_suaveolens_against_CCl4_induced_liver_damage_in_albino_rats_ L2 - https://www.tandfonline.com/doi/full/10.3109/13880200903173601 DB - PRIME DP - Unbound Medicine ER -