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Hepatoprotective effects of Ficus racemosa stem bark against carbon tetrachloride-induced hepatic damage in albino rats.
Pharm Biol. 2010 Feb; 48(2):210-6.PB

Abstract

In the present study, the hepatoprotective effects of petroleum ether (FRPE) and methanol (FRME) extract of Ficus racemosa Linn. (Moraceae) stem bark were studied using the model of hepatotoxicity induced by carbon tetrachloride (CCl(4)) in rats. CCl(4) administration induced a significant decrease in serum total protein, albumin, urea and a significant increase (P <or= 0.01) in total bilirubin associated with a marked elevation in the activities of aspartate aminotransferase (AST), alanine aminotransferase (ALT) and alkaline phosphatase (ALP) as compared to control rats. Further, CCl(4) intoxication caused significant increase in the TBARS and decrease in glutathione (GSH) levels in serum, liver and kidney. Pretreatment with FRPE and FRME restored total protein and albumin to near normal levels. Both the extracts resulted in significant decreases in the activities of AST, ALT and ALP, compared to CCl(4)-treated rats. However, a greater degree of reduction was observed in FRME pretreated group (FRPE 43%, 38%, and 33%; FRME 55%, 73%, and 38%). Total bilirubin content decreased from 2.1 mg/dL in CCl(4)-treated rats to 0.8 and 0.3 mg/dL in FRPE and FRME pretreated rats, respectively. The extracts improved the antioxidant status considerably as reflected by low TBARS and high GSH values. FRME exhibited higher hepatoprotective activity than a standard liver tonic (Liv52), while the protective effect of FRPE was similar to that of Liv52. The protective effect of F. racemosa was confirmed by histopathological profiles of the liver. The results indicate that F. racemosa possesses potent hepatoprotective effects against CCl(4)-induced hepatic damage in rats.

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Authors+Show Affiliations

Ahmed F
Department of Studies in Food Science and Nutrition, University of Mysore, Mysore, India. fayaz_ahmed09@yahoo.co.in
Urooj A
No affiliation info available

MeSH

AnimalsChemical and Drug Induced Liver InjuryChemistry, PharmaceuticalFicusGlutathioneIndiaJaundiceKidneyLipid PeroxidationLiverMaleMedicine, TraditionalPhytotherapyPlant BarkPlant ExtractsPlant StemsProtective AgentsRatsRats, WistarSolventsThiobarbituric Acid Reactive Substances

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

20645843

Citation

Ahmed, Faiyaz, and Asna Urooj. "Hepatoprotective Effects of Ficus Racemosa Stem Bark Against Carbon Tetrachloride-induced Hepatic Damage in Albino Rats." Pharmaceutical Biology, vol. 48, no. 2, 2010, pp. 210-6.
Ahmed F, Urooj A. Hepatoprotective effects of Ficus racemosa stem bark against carbon tetrachloride-induced hepatic damage in albino rats. Pharm Biol. 2010;48(2):210-6.
Ahmed, F., & Urooj, A. (2010). Hepatoprotective effects of Ficus racemosa stem bark against carbon tetrachloride-induced hepatic damage in albino rats. Pharmaceutical Biology, 48(2), 210-6. https://doi.org/10.3109/13880200903081788
Ahmed F, Urooj A. Hepatoprotective Effects of Ficus Racemosa Stem Bark Against Carbon Tetrachloride-induced Hepatic Damage in Albino Rats. Pharm Biol. 2010;48(2):210-6. PubMed PMID: 20645843.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Hepatoprotective effects of Ficus racemosa stem bark against carbon tetrachloride-induced hepatic damage in albino rats. AU - Ahmed,Faiyaz, AU - Urooj,Asna, PY - 2010/7/22/entrez PY - 2010/7/22/pubmed PY - 2010/12/14/medline SP - 210 EP - 6 JF - Pharmaceutical biology JO - Pharm Biol VL - 48 IS - 2 N2 - In the present study, the hepatoprotective effects of petroleum ether (FRPE) and methanol (FRME) extract of Ficus racemosa Linn. (Moraceae) stem bark were studied using the model of hepatotoxicity induced by carbon tetrachloride (CCl(4)) in rats. CCl(4) administration induced a significant decrease in serum total protein, albumin, urea and a significant increase (P <or= 0.01) in total bilirubin associated with a marked elevation in the activities of aspartate aminotransferase (AST), alanine aminotransferase (ALT) and alkaline phosphatase (ALP) as compared to control rats. Further, CCl(4) intoxication caused significant increase in the TBARS and decrease in glutathione (GSH) levels in serum, liver and kidney. Pretreatment with FRPE and FRME restored total protein and albumin to near normal levels. Both the extracts resulted in significant decreases in the activities of AST, ALT and ALP, compared to CCl(4)-treated rats. However, a greater degree of reduction was observed in FRME pretreated group (FRPE 43%, 38%, and 33%; FRME 55%, 73%, and 38%). Total bilirubin content decreased from 2.1 mg/dL in CCl(4)-treated rats to 0.8 and 0.3 mg/dL in FRPE and FRME pretreated rats, respectively. The extracts improved the antioxidant status considerably as reflected by low TBARS and high GSH values. FRME exhibited higher hepatoprotective activity than a standard liver tonic (Liv52), while the protective effect of FRPE was similar to that of Liv52. The protective effect of F. racemosa was confirmed by histopathological profiles of the liver. The results indicate that F. racemosa possesses potent hepatoprotective effects against CCl(4)-induced hepatic damage in rats. SN - 1744-5116 UR - https://www.unboundmedicine.com/medline/citation/20645843/Hepatoprotective_effects_of_Ficus_racemosa_stem_bark_against_carbon_tetrachloride_induced_hepatic_damage_in_albino_rats_ L2 - https://www.tandfonline.com/doi/full/10.3109/13880200903081788 DB - PRIME DP - Unbound Medicine ER -