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The endocannabinoid system and its relevance for nutrition.
Annu Rev Nutr. 2010 Aug 21; 30:423-40.AR

Abstract

Endocannabinoids bind to cannabinoid, vanilloid, and peroxisome proliferator-activated receptors. The biological actions of these polyunsaturated lipids are controlled by key agents responsible for their synthesis, transport and degradation, which together form an endocannabinoid system (ECS). In the past few years, evidence has been accumulated for a role of the ECS in regulating food intake and energy balance, both centrally and peripherally. In addition, up-regulation of the ECS in the gastrointestinal tract has a potential impact on inflammatory bowel diseases. In this review, the main features of the ECS are summarized in order to put in better focus our current knowledge of the nutritional relevance of endocannabinoid signaling and of its role in obesity, cardiovascular pathologies, and gastrointestinal diseases. The central and peripheral pathways that underlie these effects are discussed, as well as the possible exploitation of ECS components as novel drug targets for therapeutic intervention in eating disorders.

Authors+Show Affiliations

Department of Biomedical Sciences, University of Teramo, Teramo, Italy. mmaccarrone@unite.itNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

20645854

Citation

Maccarrone, Mauro, et al. "The Endocannabinoid System and Its Relevance for Nutrition." Annual Review of Nutrition, vol. 30, 2010, pp. 423-40.
Maccarrone M, Gasperi V, Catani MV, et al. The endocannabinoid system and its relevance for nutrition. Annu Rev Nutr. 2010;30:423-40.
Maccarrone, M., Gasperi, V., Catani, M. V., Diep, T. A., Dainese, E., Hansen, H. S., & Avigliano, L. (2010). The endocannabinoid system and its relevance for nutrition. Annual Review of Nutrition, 30, 423-40. https://doi.org/10.1146/annurev.nutr.012809.104701
Maccarrone M, et al. The Endocannabinoid System and Its Relevance for Nutrition. Annu Rev Nutr. 2010 Aug 21;30:423-40. PubMed PMID: 20645854.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The endocannabinoid system and its relevance for nutrition. AU - Maccarrone,Mauro, AU - Gasperi,Valeria, AU - Catani,Maria Valeria, AU - Diep,Thi Ai, AU - Dainese,Enrico, AU - Hansen,Harald S, AU - Avigliano,Luciana, PY - 2010/7/22/entrez PY - 2010/7/22/pubmed PY - 2010/10/5/medline SP - 423 EP - 40 JF - Annual review of nutrition JO - Annu. Rev. Nutr. VL - 30 N2 - Endocannabinoids bind to cannabinoid, vanilloid, and peroxisome proliferator-activated receptors. The biological actions of these polyunsaturated lipids are controlled by key agents responsible for their synthesis, transport and degradation, which together form an endocannabinoid system (ECS). In the past few years, evidence has been accumulated for a role of the ECS in regulating food intake and energy balance, both centrally and peripherally. In addition, up-regulation of the ECS in the gastrointestinal tract has a potential impact on inflammatory bowel diseases. In this review, the main features of the ECS are summarized in order to put in better focus our current knowledge of the nutritional relevance of endocannabinoid signaling and of its role in obesity, cardiovascular pathologies, and gastrointestinal diseases. The central and peripheral pathways that underlie these effects are discussed, as well as the possible exploitation of ECS components as novel drug targets for therapeutic intervention in eating disorders. SN - 1545-4312 UR - https://www.unboundmedicine.com/medline/citation/20645854/The_endocannabinoid_system_and_its_relevance_for_nutrition_ L2 - http://arjournals.annualreviews.org/doi/full/10.1146/annurev.nutr.012809.104701?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -