Tags

Type your tag names separated by a space and hit enter

The cross-sectional relationship between body mass index, waist-hip ratio, and cognitive performance in postmenopausal women enrolled in the Women's Health Initiative.
J Am Geriatr Soc 2010; 58(8):1427-32JA

Abstract

OBJECTIVES

To determine whether body mass index (BMI) is independently associated with cognitive function in postmenopausal women and the relationship between body fat distribution as estimated by waist-hip ratio (WHR).

DESIGN

Cross-sectional data analysis.

SETTING

Baseline data from the Women's Health Initiative (WHI) hormone trials.

PARTICIPANTS

Eight thousand seven hundred forty-five postmenopausal women aged 65 to 79 free of clinical evidence of dementia who completed the baseline evaluation in the WHI hormone trials.

MEASUREMENTS

Participants completed a Modified Mini-Mental State Examination (3MSE), health and lifestyle questionnaires, and standardized measurements of height, weight, body circumference, and blood pressure. Statistical analysis was performed of associations between 3MSE score, BMI, and WHR after controlling for known confounders.

RESULTS

With the exception of smoking and exercise, vascular disease risk factors, including hypertension, waist measurement, heart disease, and diabetes mellitus, were significantly associated with 3MSE score and were included as covariables in subsequent analyses. BMI was inversely related to 3MSE score; for every 1-unit increase in BMI, 3MSE score decreased 0.988 points (P<.001) after adjusting for age, education, and vascular disease risk factors. BMI had the most pronounced association with poorer cognitive functioning scores in women with smaller waist measurements. In women with the highest WHR, cognitive scores increased with BMI.

CONCLUSION

Higher BMI was associated with poorer cognitive function in women with smaller WHR. Higher WHR, estimating central fat mass, was associated with higher cognitive function in this cross-sectional study. Further research is needed to clarify the mechanism for this association.

Authors+Show Affiliations

Division of Geriatrics, Department of Medicine, Feinberg School of Medicine, Northwestern University, Chicago, Illinois 60611, USA. d-kerwin@northwestern.eduNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

20646100

Citation

Kerwin, Diana R., et al. "The Cross-sectional Relationship Between Body Mass Index, Waist-hip Ratio, and Cognitive Performance in Postmenopausal Women Enrolled in the Women's Health Initiative." Journal of the American Geriatrics Society, vol. 58, no. 8, 2010, pp. 1427-32.
Kerwin DR, Zhang Y, Kotchen JM, et al. The cross-sectional relationship between body mass index, waist-hip ratio, and cognitive performance in postmenopausal women enrolled in the Women's Health Initiative. J Am Geriatr Soc. 2010;58(8):1427-32.
Kerwin, D. R., Zhang, Y., Kotchen, J. M., Espeland, M. A., Van Horn, L., McTigue, K. M., ... Hoffmann, R. (2010). The cross-sectional relationship between body mass index, waist-hip ratio, and cognitive performance in postmenopausal women enrolled in the Women's Health Initiative. Journal of the American Geriatrics Society, 58(8), pp. 1427-32. doi:10.1111/j.1532-5415.2010.02969.x.
Kerwin DR, et al. The Cross-sectional Relationship Between Body Mass Index, Waist-hip Ratio, and Cognitive Performance in Postmenopausal Women Enrolled in the Women's Health Initiative. J Am Geriatr Soc. 2010;58(8):1427-32. PubMed PMID: 20646100.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The cross-sectional relationship between body mass index, waist-hip ratio, and cognitive performance in postmenopausal women enrolled in the Women's Health Initiative. AU - Kerwin,Diana R, AU - Zhang,Yinghua, AU - Kotchen,Jane Morley, AU - Espeland,Mark A, AU - Van Horn,Linda, AU - McTigue,Kathleen M, AU - Robinson,Jennifer G, AU - Powell,Lynda, AU - Kooperberg,Charles, AU - Coker,Laura H, AU - Hoffmann,Raymond, Y1 - 2010/07/14/ PY - 2010/7/22/entrez PY - 2010/7/22/pubmed PY - 2010/11/17/medline SP - 1427 EP - 32 JF - Journal of the American Geriatrics Society JO - J Am Geriatr Soc VL - 58 IS - 8 N2 - OBJECTIVES: To determine whether body mass index (BMI) is independently associated with cognitive function in postmenopausal women and the relationship between body fat distribution as estimated by waist-hip ratio (WHR). DESIGN: Cross-sectional data analysis. SETTING: Baseline data from the Women's Health Initiative (WHI) hormone trials. PARTICIPANTS: Eight thousand seven hundred forty-five postmenopausal women aged 65 to 79 free of clinical evidence of dementia who completed the baseline evaluation in the WHI hormone trials. MEASUREMENTS: Participants completed a Modified Mini-Mental State Examination (3MSE), health and lifestyle questionnaires, and standardized measurements of height, weight, body circumference, and blood pressure. Statistical analysis was performed of associations between 3MSE score, BMI, and WHR after controlling for known confounders. RESULTS: With the exception of smoking and exercise, vascular disease risk factors, including hypertension, waist measurement, heart disease, and diabetes mellitus, were significantly associated with 3MSE score and were included as covariables in subsequent analyses. BMI was inversely related to 3MSE score; for every 1-unit increase in BMI, 3MSE score decreased 0.988 points (P<.001) after adjusting for age, education, and vascular disease risk factors. BMI had the most pronounced association with poorer cognitive functioning scores in women with smaller waist measurements. In women with the highest WHR, cognitive scores increased with BMI. CONCLUSION: Higher BMI was associated with poorer cognitive function in women with smaller WHR. Higher WHR, estimating central fat mass, was associated with higher cognitive function in this cross-sectional study. Further research is needed to clarify the mechanism for this association. SN - 1532-5415 UR - https://www.unboundmedicine.com/medline/citation/20646100/The_cross_sectional_relationship_between_body_mass_index_waist_hip_ratio_and_cognitive_performance_in_postmenopausal_women_enrolled_in_the_Women's_Health_Initiative_ L2 - https://doi.org/10.1111/j.1532-5415.2010.02969.x DB - PRIME DP - Unbound Medicine ER -