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[The effect on life quality of nasopharyngeal cancer patients through xerostomia decrease after intensity-modulated radiotherapy].
Zhonghua Yi Xue Za Zhi. 2010 May 18; 90(19):1313-6.ZY

Abstract

OBJECTIVE

To evaluate the gain on the life quality of NPC from efforts to reduce the radiotherapy-induced xerostomia after IMRT.

METHODS

From August 2002 to December 2008, 235 patients with nasopharyngeal carcinoma were treated with IMRT in the First Affiliated Hospital of Wenzhou Medical College. Ninety-one patients with minimum 2 years of survival and no replaces and metastasis were enlisted. XQ and QOL questionnaires were completed at baseline, then 0, 3, 6, 9, 12, 18 and 24 months after IMRT.

RESULTS

The XQ scores were substantially higher at the end of IMRT compared with baseline and descended over time. At 9 months post-RT, the XQ scores improved significantly (P = 0.024) and recovered nearly to baseline at 18 months post-RT. Likewise, the QOL scores were significantly higher at the end of IMRT compared with baseline (P = 0.012) and had a sequential trend towards improvement over the study period. At 18 months post-RT, the QOL scores almost recover to baseline (P = 0.020). Multiple comparisons testing revealed that communication, eating and pain sub-scale scores were significantly higher at the end of IMRT compared with baseline(P < 0.05) with the exception of emotion domain. There was a significant correlation between XQ scores and QOL scores in general in all the study time (r = 0.976, P < 0.001), also a significant position correlation was found between XQ scores and communication, eating sub-scale scores and overall bother scores.

CONCLUSIONS

IMRT technique can reduce the incidence of postradiation xerostomia significantly and can improve the quality of life in many domains.

Authors+Show Affiliations

First Affiliated Hospital of Wenzhou Medical College, Wenzhou 325000, China.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

English Abstract
Journal Article
Research Support, Non-U.S. Gov't

Language

chi

PubMed ID

20646578

Citation

Xie, Cong-ying, et al. "[The Effect On Life Quality of Nasopharyngeal Cancer Patients Through Xerostomia Decrease After Intensity-modulated Radiotherapy]." Zhonghua Yi Xue Za Zhi, vol. 90, no. 19, 2010, pp. 1313-6.
Xie CY, Su HF, Li WF, et al. [The effect on life quality of nasopharyngeal cancer patients through xerostomia decrease after intensity-modulated radiotherapy]. Zhonghua Yi Xue Za Zhi. 2010;90(19):1313-6.
Xie, C. Y., Su, H. F., Li, W. F., Zhang, X. B., Zhang, P., Wen, H. L., & Wu, S. X. (2010). [The effect on life quality of nasopharyngeal cancer patients through xerostomia decrease after intensity-modulated radiotherapy]. Zhonghua Yi Xue Za Zhi, 90(19), 1313-6.
Xie CY, et al. [The Effect On Life Quality of Nasopharyngeal Cancer Patients Through Xerostomia Decrease After Intensity-modulated Radiotherapy]. Zhonghua Yi Xue Za Zhi. 2010 May 18;90(19):1313-6. PubMed PMID: 20646578.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [The effect on life quality of nasopharyngeal cancer patients through xerostomia decrease after intensity-modulated radiotherapy]. AU - Xie,Cong-ying, AU - Su,Hua-fang, AU - Li,Wen-feng, AU - Zhang,Xue-bang, AU - Zhang,Ping, AU - Wen,Hong-lei, AU - Wu,Shi-xiu, PY - 2010/7/22/entrez PY - 2010/7/22/pubmed PY - 2010/9/10/medline SP - 1313 EP - 6 JF - Zhonghua yi xue za zhi JO - Zhonghua Yi Xue Za Zhi VL - 90 IS - 19 N2 - OBJECTIVE: To evaluate the gain on the life quality of NPC from efforts to reduce the radiotherapy-induced xerostomia after IMRT. METHODS: From August 2002 to December 2008, 235 patients with nasopharyngeal carcinoma were treated with IMRT in the First Affiliated Hospital of Wenzhou Medical College. Ninety-one patients with minimum 2 years of survival and no replaces and metastasis were enlisted. XQ and QOL questionnaires were completed at baseline, then 0, 3, 6, 9, 12, 18 and 24 months after IMRT. RESULTS: The XQ scores were substantially higher at the end of IMRT compared with baseline and descended over time. At 9 months post-RT, the XQ scores improved significantly (P = 0.024) and recovered nearly to baseline at 18 months post-RT. Likewise, the QOL scores were significantly higher at the end of IMRT compared with baseline (P = 0.012) and had a sequential trend towards improvement over the study period. At 18 months post-RT, the QOL scores almost recover to baseline (P = 0.020). Multiple comparisons testing revealed that communication, eating and pain sub-scale scores were significantly higher at the end of IMRT compared with baseline(P < 0.05) with the exception of emotion domain. There was a significant correlation between XQ scores and QOL scores in general in all the study time (r = 0.976, P < 0.001), also a significant position correlation was found between XQ scores and communication, eating sub-scale scores and overall bother scores. CONCLUSIONS: IMRT technique can reduce the incidence of postradiation xerostomia significantly and can improve the quality of life in many domains. SN - 0376-2491 UR - https://www.unboundmedicine.com/medline/citation/20646578/[The_effect_on_life_quality_of_nasopharyngeal_cancer_patients_through_xerostomia_decrease_after_intensity_modulated_radiotherapy]_ L2 - http://journal.yiigle.com/LinkIn.do?linkin_type=pubmed&amp;issn=0376-2491&amp;year=2010&amp;vol=90&amp;issue=19&amp;fpage=1313 DB - PRIME DP - Unbound Medicine ER -