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A mechanistic modelling approach to polymer dissolution using magnetic resonance microimaging.
J Control Release. 2010 Oct 15; 147(2):232-41.JC

Abstract

In this paper a computationally efficient mathematical model describing the swelling and dissolution of a polyethylene oxide tablet is presented. The model was calibrated against polymer release, front position and water concentration profile data inside the gel layer, using two different diffusion models. The water concentration profiles were obtained from magnetic resonance microimaging data which, in addition to the previously used texture analysis method, can help to validate and discriminate between the mechanisms of swelling, diffusion and erosion in relation to the dissolution process. Critical parameters were identified through a comprehensive sensitivity analysis, and the effect of hydrodynamic shearing was investigated by using two different stirring rates. Good agreement was obtained between the experimental results and the model.

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Authors+Show Affiliations

Kaunisto E
Department of Chemical Engineering, LTH, Lund University, PO Box 124, SE-221 00 Lund, Sweden.
Abrahmsen-Alami S
No affiliation info available
Borgquist P
No affiliation info available
Larsson A
No affiliation info available
Nilsson B
No affiliation info available
Axelsson A
No affiliation info available

MeSH

Delayed-Action PreparationsDrug CarriersMagnetic Resonance ImagingModels, ChemicalPhase TransitionPolymersSolubilitySolventsTablets

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

20647024

Citation

Kaunisto, Erik, et al. "A Mechanistic Modelling Approach to Polymer Dissolution Using Magnetic Resonance Microimaging." Journal of Controlled Release : Official Journal of the Controlled Release Society, vol. 147, no. 2, 2010, pp. 232-41.
Kaunisto E, Abrahmsen-Alami S, Borgquist P, et al. A mechanistic modelling approach to polymer dissolution using magnetic resonance microimaging. J Control Release. 2010;147(2):232-41.
Kaunisto, E., Abrahmsen-Alami, S., Borgquist, P., Larsson, A., Nilsson, B., & Axelsson, A. (2010). A mechanistic modelling approach to polymer dissolution using magnetic resonance microimaging. Journal of Controlled Release : Official Journal of the Controlled Release Society, 147(2), 232-41. https://doi.org/10.1016/j.jconrel.2010.07.102
Kaunisto E, et al. A Mechanistic Modelling Approach to Polymer Dissolution Using Magnetic Resonance Microimaging. J Control Release. 2010 Oct 15;147(2):232-41. PubMed PMID: 20647024.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - A mechanistic modelling approach to polymer dissolution using magnetic resonance microimaging. AU - Kaunisto,Erik, AU - Abrahmsen-Alami,Susanna, AU - Borgquist,Per, AU - Larsson,Anette, AU - Nilsson,Bernt, AU - Axelsson,Anders, Y1 - 2010/07/18/ PY - 2010/05/18/received PY - 2010/07/07/revised PY - 2010/07/08/accepted PY - 2010/7/22/entrez PY - 2010/7/22/pubmed PY - 2011/2/22/medline SP - 232 EP - 41 JF - Journal of controlled release : official journal of the Controlled Release Society JO - J Control Release VL - 147 IS - 2 N2 - In this paper a computationally efficient mathematical model describing the swelling and dissolution of a polyethylene oxide tablet is presented. The model was calibrated against polymer release, front position and water concentration profile data inside the gel layer, using two different diffusion models. The water concentration profiles were obtained from magnetic resonance microimaging data which, in addition to the previously used texture analysis method, can help to validate and discriminate between the mechanisms of swelling, diffusion and erosion in relation to the dissolution process. Critical parameters were identified through a comprehensive sensitivity analysis, and the effect of hydrodynamic shearing was investigated by using two different stirring rates. Good agreement was obtained between the experimental results and the model. SN - 1873-4995 UR - https://www.unboundmedicine.com/medline/citation/20647024/A_mechanistic_modelling_approach_to_polymer_dissolution_using_magnetic_resonance_microimaging_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0168-3659(10)00585-7 DB - PRIME DP - Unbound Medicine ER -