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Effect of flavonol glycoside in mulberry (Morus alba L.) leaf on glucose metabolism and oxidative stress in liver in diet-induced obese mice.
J Sci Food Agric. 2010 Nov; 90(14):2386-92.JS

Abstract

BACKGROUND

Mulberry therapies on type 2 diabetic patients or streptozotocin-induced diabetic rats have been reported to improve fasting blood glucose levels. We investigated the effects of dietary consumption of mulberry-leaf powder and purified quercetin 3-(6-malonylglucoside), the quantitatively major flavonol glycoside in mulberry leaves, on glucose and lipid metabolism in high-fat diet-induced obese mice. Male C57BL/6J mice aged 8 weeks were assigned to three groups (control, mulberry leaf powder (MLP), and quercetin 3-(6-malonylglucoside) (Q3MG)) and treated with their respective diets for 8 weeks.

RESULTS

We found that dietary supplementation of 10 g MLP kg(-1) or 1 g Q3MG kg(-1) in high-fat diet effectively suppressed blood glucose levels. We also noted increased expression of glycolysis-related genes and suppression of thiobarbituric acid reactive substances concentrations in the liver of Q3MG group compared to control mice.

CONCLUSION

Dietary consumption of Q3MG, the quantitatively major flavonol glycoside in mulberry leaves, improved hyperglycemia in obese mice and reduced oxidative stress in the liver.

Authors+Show Affiliations

Shimane Institute for Industrial Technology, Matsue City, Shimane 690-0816, Japan. katsubet@icv.ne.jpNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

20648552

Citation

Katsube, Takuya, et al. "Effect of Flavonol Glycoside in Mulberry (Morus Alba L.) Leaf On Glucose Metabolism and Oxidative Stress in Liver in Diet-induced Obese Mice." Journal of the Science of Food and Agriculture, vol. 90, no. 14, 2010, pp. 2386-92.
Katsube T, Yamasaki M, Shiwaku K, et al. Effect of flavonol glycoside in mulberry (Morus alba L.) leaf on glucose metabolism and oxidative stress in liver in diet-induced obese mice. J Sci Food Agric. 2010;90(14):2386-92.
Katsube, T., Yamasaki, M., Shiwaku, K., Ishijima, T., Matsumoto, I., Abe, K., & Yamasaki, Y. (2010). Effect of flavonol glycoside in mulberry (Morus alba L.) leaf on glucose metabolism and oxidative stress in liver in diet-induced obese mice. Journal of the Science of Food and Agriculture, 90(14), 2386-92. https://doi.org/10.1002/jsfa.4096
Katsube T, et al. Effect of Flavonol Glycoside in Mulberry (Morus Alba L.) Leaf On Glucose Metabolism and Oxidative Stress in Liver in Diet-induced Obese Mice. J Sci Food Agric. 2010;90(14):2386-92. PubMed PMID: 20648552.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effect of flavonol glycoside in mulberry (Morus alba L.) leaf on glucose metabolism and oxidative stress in liver in diet-induced obese mice. AU - Katsube,Takuya, AU - Yamasaki,Masayuki, AU - Shiwaku,Kuninori, AU - Ishijima,Tomoko, AU - Matsumoto,Ichiro, AU - Abe,Keiko, AU - Yamasaki,Yukikazu, PY - 2010/7/22/entrez PY - 2010/7/22/pubmed PY - 2011/4/13/medline SP - 2386 EP - 92 JF - Journal of the science of food and agriculture JO - J. Sci. Food Agric. VL - 90 IS - 14 N2 - BACKGROUND: Mulberry therapies on type 2 diabetic patients or streptozotocin-induced diabetic rats have been reported to improve fasting blood glucose levels. We investigated the effects of dietary consumption of mulberry-leaf powder and purified quercetin 3-(6-malonylglucoside), the quantitatively major flavonol glycoside in mulberry leaves, on glucose and lipid metabolism in high-fat diet-induced obese mice. Male C57BL/6J mice aged 8 weeks were assigned to three groups (control, mulberry leaf powder (MLP), and quercetin 3-(6-malonylglucoside) (Q3MG)) and treated with their respective diets for 8 weeks. RESULTS: We found that dietary supplementation of 10 g MLP kg(-1) or 1 g Q3MG kg(-1) in high-fat diet effectively suppressed blood glucose levels. We also noted increased expression of glycolysis-related genes and suppression of thiobarbituric acid reactive substances concentrations in the liver of Q3MG group compared to control mice. CONCLUSION: Dietary consumption of Q3MG, the quantitatively major flavonol glycoside in mulberry leaves, improved hyperglycemia in obese mice and reduced oxidative stress in the liver. SN - 1097-0010 UR - https://www.unboundmedicine.com/medline/citation/20648552/Effect_of_flavonol_glycoside_in_mulberry__Morus_alba_L___leaf_on_glucose_metabolism_and_oxidative_stress_in_liver_in_diet_induced_obese_mice_ L2 - https://doi.org/10.1002/jsfa.4096 DB - PRIME DP - Unbound Medicine ER -