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Patients with type 2 diabetes mellitus have higher risk for acute pancreatitis compared with those without diabetes.
Diabetes Obes Metab. 2010 Sep; 12(9):766-71.DO

Abstract

AIM

The aetiology of acute pancreatitis (AP) is complex, and many risk factors for AP are shared by patients with type 2 diabetes mellitus (T2DM). However, few have assessed risk factors for AP specifically in T2DM patients.

METHODS

Patients in the General Practice Research Database (2 984 755, 5.0% with T2DM) were used to estimate incidence of AP for T2DM relative to non-diabetes, adjusting for prior pancreatitis, gallbladder disease, obesity, smoking and alcohol use. Multivariate Cox regression analysis adjusting for risk factors and Charlson comorbidity index (CCI) was used to estimate hazard ratios (HR) with 95% confidence intervals (CI).

RESULTS

Between 2003 and 2007, 301 of 148 903 patients with T2DM and 2434 of almost 3 million patients without diabetes developed AP. Patients with T2DM had higher risk for AP compared with patients without diabetes (crude HR: 2.89, 95% CI: 2.56-3.27). Patients with T2DM had significantly higher rates of prior alcohol and tobacco exposure (44.2 and 61.9% vs. 34.1 and 35.9%, p < 0.001) and of comorbid conditions (14.7% with CCI > or =1 vs. 4.3%, p < 0.001). Histories of obesity, pancreatitis, gallbladder disease, smoking or alcohol use were significant predictors of AP. After adjusting for these factors, age, gender and comorbidities, the risk of developing AP remained elevated in patients with T2DM (adjusted HR: 1.49, 95% CI: 1.31-1.70).

CONCLUSION

After adjusting for risk factors, patients with T2DM had an elevated risk of AP compared with patients without diabetes. Physicians should be aware of the increased risk in patients with T2DM, particularly in those with prior pancreatitis.

Authors+Show Affiliations

Global Clinical Development and Regulatory Affairs, Merck Research Laboratories, North Wales, PA 19454, USA. cindy_girman@merck.comNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

20649628

Citation

Girman, C J., et al. "Patients With Type 2 Diabetes Mellitus Have Higher Risk for Acute Pancreatitis Compared With Those Without Diabetes." Diabetes, Obesity & Metabolism, vol. 12, no. 9, 2010, pp. 766-71.
Girman CJ, Kou TD, Cai B, et al. Patients with type 2 diabetes mellitus have higher risk for acute pancreatitis compared with those without diabetes. Diabetes Obes Metab. 2010;12(9):766-71.
Girman, C. J., Kou, T. D., Cai, B., Alexander, C. M., O'Neill, E. A., Williams-Herman, D. E., & Katz, L. (2010). Patients with type 2 diabetes mellitus have higher risk for acute pancreatitis compared with those without diabetes. Diabetes, Obesity & Metabolism, 12(9), 766-71. https://doi.org/10.1111/j.1463-1326.2010.01231.x
Girman CJ, et al. Patients With Type 2 Diabetes Mellitus Have Higher Risk for Acute Pancreatitis Compared With Those Without Diabetes. Diabetes Obes Metab. 2010;12(9):766-71. PubMed PMID: 20649628.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Patients with type 2 diabetes mellitus have higher risk for acute pancreatitis compared with those without diabetes. AU - Girman,C J, AU - Kou,T D, AU - Cai,B, AU - Alexander,C M, AU - O'Neill,E A, AU - Williams-Herman,D E, AU - Katz,L, PY - 2010/7/24/entrez PY - 2010/7/24/pubmed PY - 2011/3/17/medline SP - 766 EP - 71 JF - Diabetes, obesity & metabolism JO - Diabetes Obes Metab VL - 12 IS - 9 N2 - AIM: The aetiology of acute pancreatitis (AP) is complex, and many risk factors for AP are shared by patients with type 2 diabetes mellitus (T2DM). However, few have assessed risk factors for AP specifically in T2DM patients. METHODS: Patients in the General Practice Research Database (2 984 755, 5.0% with T2DM) were used to estimate incidence of AP for T2DM relative to non-diabetes, adjusting for prior pancreatitis, gallbladder disease, obesity, smoking and alcohol use. Multivariate Cox regression analysis adjusting for risk factors and Charlson comorbidity index (CCI) was used to estimate hazard ratios (HR) with 95% confidence intervals (CI). RESULTS: Between 2003 and 2007, 301 of 148 903 patients with T2DM and 2434 of almost 3 million patients without diabetes developed AP. Patients with T2DM had higher risk for AP compared with patients without diabetes (crude HR: 2.89, 95% CI: 2.56-3.27). Patients with T2DM had significantly higher rates of prior alcohol and tobacco exposure (44.2 and 61.9% vs. 34.1 and 35.9%, p < 0.001) and of comorbid conditions (14.7% with CCI > or =1 vs. 4.3%, p < 0.001). Histories of obesity, pancreatitis, gallbladder disease, smoking or alcohol use were significant predictors of AP. After adjusting for these factors, age, gender and comorbidities, the risk of developing AP remained elevated in patients with T2DM (adjusted HR: 1.49, 95% CI: 1.31-1.70). CONCLUSION: After adjusting for risk factors, patients with T2DM had an elevated risk of AP compared with patients without diabetes. Physicians should be aware of the increased risk in patients with T2DM, particularly in those with prior pancreatitis. SN - 1463-1326 UR - https://www.unboundmedicine.com/medline/citation/20649628/full_citation L2 - https://doi.org/10.1111/j.1463-1326.2010.01231.x DB - PRIME DP - Unbound Medicine ER -