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Epidemiology of viral respiratory tract infections in a prospective cohort of infants and toddlers attending daycare.
J Clin Virol. 2010 Sep; 49(1):16-20.JC

Abstract

BACKGROUND

The epidemiology of respiratory tract infections (RTIs) in a daycare cohort has not been explored using molecular techniques.

OBJECTIVES

(1) Determine the overall incidence of RTIs in a daycare cohort using real-time reverse transcriptase polymerase chain reaction (RT-PCR). (2) Determine the relative incidence and impact of specific respiratory viruses, and characterize and compare clinical features associated with these pathogens.

STUDY DESIGN

In this prospective cohort study conducted from February 2006 to April 2008, nasal swabs were obtained from symptomatic children ages 0-30 months enrolled in fulltime daycare. RT-PCR was performed to detect respiratory syncytial virus (RSV), human metapneumovirus (MPV), influenza (Flu) viruses A and B, parainfluenza (PIV), adenovirus (AdV), human coronaviruses (CoV) and rhinovirus (RhV). Symptom diaries were completed for each illness.

RESULTS

We followed 119 children (mean age 10 months; range 2-24 months) for 115 child years. The mean annual incidence of RTI per child was 4.2 the first year and 1.2 the second year of the study. At least 1 virus was identified in 67% RTIs. Co-infections were common (27% RTIs), with RhV, CoV, and AdV the most common co-pathogens. PIV was identified in 12% of RTIs with a high incidence of PIV4. The viruses with the greatest impact on our population were RSV, RhV and AdV.

CONCLUSIONS

Using molecular techniques, viruses were identified in approximately twice as many RTIs as previously reported in a daycare cohort. Infections with newly identified viruses, such as HMPV and CoV subtypes were less frequent and severe than infections with RSV, AdV and RhV.

Authors+Show Affiliations

Department of Pediatrics, Madigan Army Medical Center, BLDG 9040 Fitzsimmons Drive, Tacoma, WA 98431, United States. fairchokmp@hotmail.comNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

20650679

Citation

Fairchok, Mary P., et al. "Epidemiology of Viral Respiratory Tract Infections in a Prospective Cohort of Infants and Toddlers Attending Daycare." Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology, vol. 49, no. 1, 2010, pp. 16-20.
Fairchok MP, Martin ET, Chambers S, et al. Epidemiology of viral respiratory tract infections in a prospective cohort of infants and toddlers attending daycare. J Clin Virol. 2010;49(1):16-20.
Fairchok, M. P., Martin, E. T., Chambers, S., Kuypers, J., Behrens, M., Braun, L. E., & Englund, J. A. (2010). Epidemiology of viral respiratory tract infections in a prospective cohort of infants and toddlers attending daycare. Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology, 49(1), 16-20. https://doi.org/10.1016/j.jcv.2010.06.013
Fairchok MP, et al. Epidemiology of Viral Respiratory Tract Infections in a Prospective Cohort of Infants and Toddlers Attending Daycare. J Clin Virol. 2010;49(1):16-20. PubMed PMID: 20650679.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Epidemiology of viral respiratory tract infections in a prospective cohort of infants and toddlers attending daycare. AU - Fairchok,Mary P, AU - Martin,Emily T, AU - Chambers,Susan, AU - Kuypers,Jane, AU - Behrens,Melinda, AU - Braun,Loranee E, AU - Englund,Janet A, Y1 - 2010/07/21/ PY - 2010/01/13/received PY - 2010/06/22/revised PY - 2010/06/28/accepted PY - 2010/7/24/entrez PY - 2010/7/24/pubmed PY - 2010/12/17/medline SP - 16 EP - 20 JF - Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology JO - J. Clin. Virol. VL - 49 IS - 1 N2 - BACKGROUND: The epidemiology of respiratory tract infections (RTIs) in a daycare cohort has not been explored using molecular techniques. OBJECTIVES: (1) Determine the overall incidence of RTIs in a daycare cohort using real-time reverse transcriptase polymerase chain reaction (RT-PCR). (2) Determine the relative incidence and impact of specific respiratory viruses, and characterize and compare clinical features associated with these pathogens. STUDY DESIGN: In this prospective cohort study conducted from February 2006 to April 2008, nasal swabs were obtained from symptomatic children ages 0-30 months enrolled in fulltime daycare. RT-PCR was performed to detect respiratory syncytial virus (RSV), human metapneumovirus (MPV), influenza (Flu) viruses A and B, parainfluenza (PIV), adenovirus (AdV), human coronaviruses (CoV) and rhinovirus (RhV). Symptom diaries were completed for each illness. RESULTS: We followed 119 children (mean age 10 months; range 2-24 months) for 115 child years. The mean annual incidence of RTI per child was 4.2 the first year and 1.2 the second year of the study. At least 1 virus was identified in 67% RTIs. Co-infections were common (27% RTIs), with RhV, CoV, and AdV the most common co-pathogens. PIV was identified in 12% of RTIs with a high incidence of PIV4. The viruses with the greatest impact on our population were RSV, RhV and AdV. CONCLUSIONS: Using molecular techniques, viruses were identified in approximately twice as many RTIs as previously reported in a daycare cohort. Infections with newly identified viruses, such as HMPV and CoV subtypes were less frequent and severe than infections with RSV, AdV and RhV. SN - 1873-5967 UR - https://www.unboundmedicine.com/medline/citation/20650679/Epidemiology_of_viral_respiratory_tract_infections_in_a_prospective_cohort_of_infants_and_toddlers_attending_daycare_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1386-6532(10)00257-X DB - PRIME DP - Unbound Medicine ER -