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[Simultaneous determination of ibuprofen and pseudoephedrin hydrochloride and chlorpheniramine maleate in the compound buluoweimanamin tablets by HPLC].
Nan Fang Yi Ke Da Xue Xue Bao. 2010 Jul; 30(7):1703-4.NF

Abstract

OBJECTIVE

An HPLC method was developed to determinate Ibuprofen and Pseudoephedrine Hydrochloride and Chlorpheniramine Maleate in Compound BuluoWeimaNamin Tablets.

METHODS

Using HPLC with Kromasil C18 column, and acetonitrile -0.5% SDS- phosphate (580:420:1) as the mobile phase. The wavelength for detection was 262 nm.

RESULTS

Better linearities and good correlation coefficients were obtained: the concentration ranges of ibuprofen, pseudoephedrine hydrochloride and chlorpheniramine maleate were over 2.062-14.434 microg (r=0.9999), 0.296-2.072l microg (r=0.9999), and 0.0204~0.1428 microg (r=0.9998), respectively. The recoveries of ibuprofen, pseudoephedrine hydrochloride and chlorpheniramine maleate were 99.98% (RSD=0.52%), 99.72 (RSD=0.82%) and 99.545 (RSD=0.76%), respectively.

CONCLUSION

The method was convenient, accurate and specific. It can be used as a method to control quality of Compound Buluoweimanamin Tablets.

Authors+Show Affiliations

Yin SF
Chongqing Medical University College of Pharmacy, Chongqing 400016, China. ysf906@163.com
Qiu ZY
No affiliation info available

MeSH

ChlorpheniramineChromatography, High Pressure LiquidIbuprofenPseudoephedrineTablets

Pub Type(s)

English Abstract
Journal Article

Language

chi

PubMed ID

20650805

Citation

Yin, San-fu, and Zong-yin Qiu. "[Simultaneous Determination of Ibuprofen and Pseudoephedrin Hydrochloride and Chlorpheniramine Maleate in the Compound Buluoweimanamin Tablets By HPLC]." Nan Fang Yi Ke Da Xue Xue Bao = Journal of Southern Medical University, vol. 30, no. 7, 2010, pp. 1703-4.
Yin SF, Qiu ZY. [Simultaneous determination of ibuprofen and pseudoephedrin hydrochloride and chlorpheniramine maleate in the compound buluoweimanamin tablets by HPLC]. Nan Fang Yi Ke Da Xue Xue Bao. 2010;30(7):1703-4.
Yin, S. F., & Qiu, Z. Y. (2010). [Simultaneous determination of ibuprofen and pseudoephedrin hydrochloride and chlorpheniramine maleate in the compound buluoweimanamin tablets by HPLC]. Nan Fang Yi Ke Da Xue Xue Bao = Journal of Southern Medical University, 30(7), 1703-4.
Yin SF, Qiu ZY. [Simultaneous Determination of Ibuprofen and Pseudoephedrin Hydrochloride and Chlorpheniramine Maleate in the Compound Buluoweimanamin Tablets By HPLC]. Nan Fang Yi Ke Da Xue Xue Bao. 2010;30(7):1703-4. PubMed PMID: 20650805.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Simultaneous determination of ibuprofen and pseudoephedrin hydrochloride and chlorpheniramine maleate in the compound buluoweimanamin tablets by HPLC]. AU - Yin,San-fu, AU - Qiu,Zong-yin, PY - 2010/7/24/entrez PY - 2010/7/24/pubmed PY - 2013/6/26/medline SP - 1703 EP - 4 JF - Nan fang yi ke da xue xue bao = Journal of Southern Medical University JO - Nan Fang Yi Ke Da Xue Xue Bao VL - 30 IS - 7 N2 - OBJECTIVE: An HPLC method was developed to determinate Ibuprofen and Pseudoephedrine Hydrochloride and Chlorpheniramine Maleate in Compound BuluoWeimaNamin Tablets. METHODS: Using HPLC with Kromasil C18 column, and acetonitrile -0.5% SDS- phosphate (580:420:1) as the mobile phase. The wavelength for detection was 262 nm. RESULTS: Better linearities and good correlation coefficients were obtained: the concentration ranges of ibuprofen, pseudoephedrine hydrochloride and chlorpheniramine maleate were over 2.062-14.434 microg (r=0.9999), 0.296-2.072l microg (r=0.9999), and 0.0204~0.1428 microg (r=0.9998), respectively. The recoveries of ibuprofen, pseudoephedrine hydrochloride and chlorpheniramine maleate were 99.98% (RSD=0.52%), 99.72 (RSD=0.82%) and 99.545 (RSD=0.76%), respectively. CONCLUSION: The method was convenient, accurate and specific. It can be used as a method to control quality of Compound Buluoweimanamin Tablets. SN - 1673-4254 UR - https://www.unboundmedicine.com/medline/citation/20650805/[Simultaneous_determination_of_ibuprofen_and_pseudoephedrin_hydrochloride_and_chlorpheniramine_maleate_in_the_compound_buluoweimanamin_tablets_by_HPLC]_ DB - PRIME DP - Unbound Medicine ER -