Tags

Type your tag names separated by a space and hit enter

Acquired vulvar lymphangioma circumscriptum: a comparison of 12 cases with Crohn's associated lesions or radiation therapy induced tumors.
J Cutan Pathol. 2010 Sep; 37(9):958-65.JC

Abstract

BACKGROUND

Lymphangioma circumscriptum (LC) is a benign lesion of lymphatic origin. Vulvar involvement occurs in various clinical settings.

METHODS

We present 12 cases, and compare lesions in patients with Crohn's disease and those associated with pelvic radiation.

RESULTS

The average age at presentation was 49 years. Thirty-three percent of the patients had Crohn's disease, 58% had radiation therapy and 9% had no significant medical history. Sixty-seven percent of the patients had multifocal lesions in anatomically distinct regions. Patients presented on average 16 years after onset of predisposing factors. Presenting complaints were pruritus, wetness and vulvar edema. Lesions were clinically heterogeneous, often found on the labia majora. Lesions consisted of dilated lymphatic channels at the junction of the reticular and papillary dermis. The cells lining these spaces lacked cytologic atypicality or mitotic activity. All lesions so examined were immunoreactive for D240. Patients were most often treated with surgical excision followed by laser ablation. Four of twelve patients, all with radiation-associated lesions, experienced disease progression necessitating additional surgery.

CONCLUSIONS

Patients with LC secondary to radiation, when compared to those with Crohn's disease, were 10 years younger, more likely to have associated co-morbidities, and frequently experienced disease progression needing additional surgeries. Acquired vulvar LC has multiple causes with differing prognosis.

Authors+Show Affiliations

Department of Pathology, Duke University Medical Center, Durham, NC 27710, USA. papal002@mc.duke.eduNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

20653826

Citation

Papalas, John A., et al. "Acquired Vulvar Lymphangioma Circumscriptum: a Comparison of 12 Cases With Crohn's Associated Lesions or Radiation Therapy Induced Tumors." Journal of Cutaneous Pathology, vol. 37, no. 9, 2010, pp. 958-65.
Papalas JA, Robboy SJ, Burchette JL, et al. Acquired vulvar lymphangioma circumscriptum: a comparison of 12 cases with Crohn's associated lesions or radiation therapy induced tumors. J Cutan Pathol. 2010;37(9):958-65.
Papalas, J. A., Robboy, S. J., Burchette, J. L., Foo, W. C., & Selim, M. A. (2010). Acquired vulvar lymphangioma circumscriptum: a comparison of 12 cases with Crohn's associated lesions or radiation therapy induced tumors. Journal of Cutaneous Pathology, 37(9), 958-65. https://doi.org/10.1111/j.1600-0560.2010.01569.x
Papalas JA, et al. Acquired Vulvar Lymphangioma Circumscriptum: a Comparison of 12 Cases With Crohn's Associated Lesions or Radiation Therapy Induced Tumors. J Cutan Pathol. 2010;37(9):958-65. PubMed PMID: 20653826.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Acquired vulvar lymphangioma circumscriptum: a comparison of 12 cases with Crohn's associated lesions or radiation therapy induced tumors. AU - Papalas,John A, AU - Robboy,Stanley J, AU - Burchette,James L, AU - Foo,Wen-Chi, AU - Selim,M Angelica, PY - 2010/7/27/entrez PY - 2010/7/27/pubmed PY - 2010/10/27/medline SP - 958 EP - 65 JF - Journal of cutaneous pathology JO - J. Cutan. Pathol. VL - 37 IS - 9 N2 - BACKGROUND: Lymphangioma circumscriptum (LC) is a benign lesion of lymphatic origin. Vulvar involvement occurs in various clinical settings. METHODS: We present 12 cases, and compare lesions in patients with Crohn's disease and those associated with pelvic radiation. RESULTS: The average age at presentation was 49 years. Thirty-three percent of the patients had Crohn's disease, 58% had radiation therapy and 9% had no significant medical history. Sixty-seven percent of the patients had multifocal lesions in anatomically distinct regions. Patients presented on average 16 years after onset of predisposing factors. Presenting complaints were pruritus, wetness and vulvar edema. Lesions were clinically heterogeneous, often found on the labia majora. Lesions consisted of dilated lymphatic channels at the junction of the reticular and papillary dermis. The cells lining these spaces lacked cytologic atypicality or mitotic activity. All lesions so examined were immunoreactive for D240. Patients were most often treated with surgical excision followed by laser ablation. Four of twelve patients, all with radiation-associated lesions, experienced disease progression necessitating additional surgery. CONCLUSIONS: Patients with LC secondary to radiation, when compared to those with Crohn's disease, were 10 years younger, more likely to have associated co-morbidities, and frequently experienced disease progression needing additional surgeries. Acquired vulvar LC has multiple causes with differing prognosis. SN - 1600-0560 UR - https://www.unboundmedicine.com/medline/citation/20653826/Acquired_vulvar_lymphangioma_circumscriptum:_a_comparison_of_12_cases_with_Crohn's_associated_lesions_or_radiation_therapy_induced_tumors_ L2 - https://doi.org/10.1111/j.1600-0560.2010.01569.x DB - PRIME DP - Unbound Medicine ER -