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Control of soil-transmitted helminths in sub-Saharan Africa: diagnosis, drug efficacy concerns and challenges.
Acta Trop. 2011 Sep; 120 Suppl 1:S4-11.AT

Abstract

Soil-transmitted helminthiasis (STH) occur throughout the developing world and remain a major public health problem in the poorest communities with enormous consequences on health and development of school-aged and preschool children. The extent of the problem has long been neglected because these diseases rarely kill at a young age, due to their insidious and chronic nature. Today there exists a momentum and an unprecedented opportunity for a cost-effective control of these neglected tropical diseases. The control of these diseases has become a priority on the agenda of many governments, donors and international agencies, which provides important funding opportunities for STH control through integration and co-implementation of control interventions. In the era of preventive chemotherapy, the intensification of mass administration of anthelminthic drugs will result in epidemiological changes of STH transmission levels, with a rapid increase of light infections as far as control programmes are successful. As consequence, the current diagnostic tools may not be always appropriate and may therefore require adaptation or development of alternative assays adapted to the stage of control. This paper reviews aspects relevant to diagnosis and appropriate tools for accurate surveillance and monitoring of STH control programmes and drug efficacy. Prospects, opportunities and challenges for the control are discussed.

Authors+Show Affiliations

National Programme for the Control of Schistosomiasis and Intestinal Helminthiasis, Ministry of Public Health, Yaoundé, Cameroon. tchuemtchuente@schisto.com

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

20654570

Citation

Tchuem Tchuenté, L A.. "Control of Soil-transmitted Helminths in sub-Saharan Africa: Diagnosis, Drug Efficacy Concerns and Challenges." Acta Tropica, vol. 120 Suppl 1, 2011, pp. S4-11.
Tchuem Tchuenté LA. Control of soil-transmitted helminths in sub-Saharan Africa: diagnosis, drug efficacy concerns and challenges. Acta Trop. 2011;120 Suppl 1:S4-11.
Tchuem Tchuenté, L. A. (2011). Control of soil-transmitted helminths in sub-Saharan Africa: diagnosis, drug efficacy concerns and challenges. Acta Tropica, 120 Suppl 1, S4-11. https://doi.org/10.1016/j.actatropica.2010.07.001
Tchuem Tchuenté LA. Control of Soil-transmitted Helminths in sub-Saharan Africa: Diagnosis, Drug Efficacy Concerns and Challenges. Acta Trop. 2011;120 Suppl 1:S4-11. PubMed PMID: 20654570.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Control of soil-transmitted helminths in sub-Saharan Africa: diagnosis, drug efficacy concerns and challenges. A1 - Tchuem Tchuenté,L A, Y1 - 2010/07/21/ PY - 2009/10/07/received PY - 2010/06/28/revised PY - 2010/07/02/accepted PY - 2010/7/27/entrez PY - 2010/7/27/pubmed PY - 2012/1/24/medline SP - S4 EP - 11 JF - Acta tropica JO - Acta Trop VL - 120 Suppl 1 N2 - Soil-transmitted helminthiasis (STH) occur throughout the developing world and remain a major public health problem in the poorest communities with enormous consequences on health and development of school-aged and preschool children. The extent of the problem has long been neglected because these diseases rarely kill at a young age, due to their insidious and chronic nature. Today there exists a momentum and an unprecedented opportunity for a cost-effective control of these neglected tropical diseases. The control of these diseases has become a priority on the agenda of many governments, donors and international agencies, which provides important funding opportunities for STH control through integration and co-implementation of control interventions. In the era of preventive chemotherapy, the intensification of mass administration of anthelminthic drugs will result in epidemiological changes of STH transmission levels, with a rapid increase of light infections as far as control programmes are successful. As consequence, the current diagnostic tools may not be always appropriate and may therefore require adaptation or development of alternative assays adapted to the stage of control. This paper reviews aspects relevant to diagnosis and appropriate tools for accurate surveillance and monitoring of STH control programmes and drug efficacy. Prospects, opportunities and challenges for the control are discussed. SN - 1873-6254 UR - https://www.unboundmedicine.com/medline/citation/20654570/Control_of_soil_transmitted_helminths_in_sub_Saharan_Africa:_diagnosis_drug_efficacy_concerns_and_challenges_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0001-706X(10)00182-8 DB - PRIME DP - Unbound Medicine ER -