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IgA anti-actin antibodies in celiac disease.
Gastroenterol Clin Biol 2010; 34(8-9):483-7GC

Abstract

AIMS

The purpose of this study was to determine the sensitivity and specificity of IgA anti-actin antibodies (IgA-AAA) for celiac disease (CD), to investigate their usefulness as a marker of compliance in CD patients to the gluten-free diet (GFD), and to assess the relationship between their presence in the sera of CD patients and severity of intestinal mucosal damage.

PATIENTS AND METHODS

A total of 182 patients with CD were studied: 63 patients were untreated; 50 patients were following a strict GFD; and 69 patients were non-compliant with a GFD. IgA-AAA was detected using a homemade enzyme-linked immunosorbent assay (ELISA).

RESULTS

IgA-AAA showed a sensitivity of 41.3% and a specificity of 71.4% for a diagnosis of CD. In children, the frequency of IgA-AAA detection was lower in those following a strict GFD (23.1%) compared with untreated patients (39.4%) and those not complying with a GFD (32.5%). In patients following a strict GFD, IgA-AAA detection was significantly less frequent in children than in adults (23.1% vs. 58.3%, respectively; P<0.001). IgA-AAA was found in 17 out of 52 CD patients with total villous atrophy (32.7%), and in one out of 11 patients with subtotal villous atrophy (9%).

CONCLUSION

IgA-AAA cannot replace anti-endomysium and anti-tissue transglutaminase antibodies in the diagnosis algorithm of CD, but it can serve as a reliable marker of severe intestinal mucosal damage in CD patients.

Authors+Show Affiliations

Autoimmunity and Allergy Research Unit, Faculty of Pharmacy, Monastir, Tunisia.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

20655155

Citation

Achour, A, et al. "IgA Anti-actin Antibodies in Celiac Disease." Gastroenterologie Clinique Et Biologique, vol. 34, no. 8-9, 2010, pp. 483-7.
Achour A, Thabet Y, Sakly W, et al. IgA anti-actin antibodies in celiac disease. Gastroenterol Clin Biol. 2010;34(8-9):483-7.
Achour, A., Thabet, Y., Sakly, W., Mankai, A., Sakly, N., Ayadi, A., ... Ghedira, I. (2010). IgA anti-actin antibodies in celiac disease. Gastroenterologie Clinique Et Biologique, 34(8-9), pp. 483-7. doi:10.1016/j.gcb.2010.01.023.
Achour A, et al. IgA Anti-actin Antibodies in Celiac Disease. Gastroenterol Clin Biol. 2010;34(8-9):483-7. PubMed PMID: 20655155.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - IgA anti-actin antibodies in celiac disease. AU - Achour,A, AU - Thabet,Y, AU - Sakly,W, AU - Mankai,A, AU - Sakly,N, AU - Ayadi,A, AU - Sfar,M T, AU - Amri,F, AU - Harbi,A, AU - Essoussi,A S, AU - Krifa,A, AU - Ajmi,S, AU - Ghedira,I, Y1 - 2010/07/23/ PY - 2009/11/25/received PY - 2010/01/24/accepted PY - 2010/7/27/entrez PY - 2010/7/27/pubmed PY - 2011/1/11/medline SP - 483 EP - 7 JF - Gastroenterologie clinique et biologique JO - Gastroenterol. Clin. Biol. VL - 34 IS - 8-9 N2 - AIMS: The purpose of this study was to determine the sensitivity and specificity of IgA anti-actin antibodies (IgA-AAA) for celiac disease (CD), to investigate their usefulness as a marker of compliance in CD patients to the gluten-free diet (GFD), and to assess the relationship between their presence in the sera of CD patients and severity of intestinal mucosal damage. PATIENTS AND METHODS: A total of 182 patients with CD were studied: 63 patients were untreated; 50 patients were following a strict GFD; and 69 patients were non-compliant with a GFD. IgA-AAA was detected using a homemade enzyme-linked immunosorbent assay (ELISA). RESULTS: IgA-AAA showed a sensitivity of 41.3% and a specificity of 71.4% for a diagnosis of CD. In children, the frequency of IgA-AAA detection was lower in those following a strict GFD (23.1%) compared with untreated patients (39.4%) and those not complying with a GFD (32.5%). In patients following a strict GFD, IgA-AAA detection was significantly less frequent in children than in adults (23.1% vs. 58.3%, respectively; P<0.001). IgA-AAA was found in 17 out of 52 CD patients with total villous atrophy (32.7%), and in one out of 11 patients with subtotal villous atrophy (9%). CONCLUSION: IgA-AAA cannot replace anti-endomysium and anti-tissue transglutaminase antibodies in the diagnosis algorithm of CD, but it can serve as a reliable marker of severe intestinal mucosal damage in CD patients. SN - 0399-8320 UR - https://www.unboundmedicine.com/medline/citation/20655155/IgA_anti_actin_antibodies_in_celiac_disease_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0399-8320(10)00215-0 DB - PRIME DP - Unbound Medicine ER -