Tags

Type your tag names separated by a space and hit enter

Immunohistochemical evaluation of mast cells and angiogenesis in oral squamous cell carcinoma.
Indian J Dent Res. 2010 Apr-Jun; 21(2):260-5.IJ

Abstract

OBJECTIVES

Angiogenesis is a complex event mediated by angiogenic factors released from cancer cells and immune cells. It has been reported to be associated with progression, aggressiveness and metastases of various malignant tumors including oral squamous cell carcinoma (OSCC). Similarly, mast cells have also been reported to play a role in tumor progression and metastases by promoting angiogenesis. The present study aims at comparison of microvascular density (MVD) and mast cell density (MCD) in normal oral mucosa (NM) and among various grades of OSCC.

MATERIALS AND METHODS

MVD was assessed immunohistochemically using anti-Factor VIII related von Willebrand factor, and MCD using anti-mast cell tryptase in a study sample of 30 cases of OSCC and 10 cases of clinically normal oral mucosa.

RESULTS

The mast cells in normal oral mucosa and oral squamous cell carcinoma strongly expressed mast cell tryptase. The density of mast cells and micro vessels were significantly higher in OSCC compared to normal oral mucosa. The MCD and MVD were higher in moderately differentiated OSCC than in well differentiated OSCC (P > 0.05) and normal oral mucosa (P < 0.05). Pearson's correlation revealed a positive correlation between MCD and MVD (r=0.33; P=0.077).

CONCLUSION

These findings indicate that mast cells may play a role in up regulation of tumor angiogenesis in OSCC probably through mast cell tryptase.

Authors+Show Affiliations

Department of Oral and Maxillofacial Pathology, Meenakshi Ammal Dental College, Chennai, India.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

20657098

Citation

Sharma, Bhushan, et al. "Immunohistochemical Evaluation of Mast Cells and Angiogenesis in Oral Squamous Cell Carcinoma." Indian Journal of Dental Research : Official Publication of Indian Society for Dental Research, vol. 21, no. 2, 2010, pp. 260-5.
Sharma B, Sriram G, Saraswathi TR, et al. Immunohistochemical evaluation of mast cells and angiogenesis in oral squamous cell carcinoma. Indian J Dent Res. 2010;21(2):260-5.
Sharma, B., Sriram, G., Saraswathi, T. R., & Sivapathasundharam, B. (2010). Immunohistochemical evaluation of mast cells and angiogenesis in oral squamous cell carcinoma. Indian Journal of Dental Research : Official Publication of Indian Society for Dental Research, 21(2), 260-5. https://doi.org/10.4103/0970-9290.66655
Sharma B, et al. Immunohistochemical Evaluation of Mast Cells and Angiogenesis in Oral Squamous Cell Carcinoma. Indian J Dent Res. 2010 Apr-Jun;21(2):260-5. PubMed PMID: 20657098.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Immunohistochemical evaluation of mast cells and angiogenesis in oral squamous cell carcinoma. AU - Sharma,Bhushan, AU - Sriram,G, AU - Saraswathi,T R, AU - Sivapathasundharam,B, PY - 2010/7/27/entrez PY - 2010/7/27/pubmed PY - 2010/11/10/medline SP - 260 EP - 5 JF - Indian journal of dental research : official publication of Indian Society for Dental Research JO - Indian J Dent Res VL - 21 IS - 2 N2 - OBJECTIVES: Angiogenesis is a complex event mediated by angiogenic factors released from cancer cells and immune cells. It has been reported to be associated with progression, aggressiveness and metastases of various malignant tumors including oral squamous cell carcinoma (OSCC). Similarly, mast cells have also been reported to play a role in tumor progression and metastases by promoting angiogenesis. The present study aims at comparison of microvascular density (MVD) and mast cell density (MCD) in normal oral mucosa (NM) and among various grades of OSCC. MATERIALS AND METHODS: MVD was assessed immunohistochemically using anti-Factor VIII related von Willebrand factor, and MCD using anti-mast cell tryptase in a study sample of 30 cases of OSCC and 10 cases of clinically normal oral mucosa. RESULTS: The mast cells in normal oral mucosa and oral squamous cell carcinoma strongly expressed mast cell tryptase. The density of mast cells and micro vessels were significantly higher in OSCC compared to normal oral mucosa. The MCD and MVD were higher in moderately differentiated OSCC than in well differentiated OSCC (P > 0.05) and normal oral mucosa (P < 0.05). Pearson's correlation revealed a positive correlation between MCD and MVD (r=0.33; P=0.077). CONCLUSION: These findings indicate that mast cells may play a role in up regulation of tumor angiogenesis in OSCC probably through mast cell tryptase. SN - 1998-3603 UR - https://www.unboundmedicine.com/medline/citation/20657098/Immunohistochemical_evaluation_of_mast_cells_and_angiogenesis_in_oral_squamous_cell_carcinoma_ L2 - http://www.ijdr.in/article.asp?issn=0970-9290;year=2010;volume=21;issue=2;spage=260;epage=265;aulast=Sharma DB - PRIME DP - Unbound Medicine ER -