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A novel dimeric coumarin analog and antimycobacterial constituents from Fatoua pilosa.
Chem Biodivers. 2010 Jul; 7(7):1728-36.CB

Abstract

One novel dimeric coumarin analog, fatouapilosin (1), together with 18 known compounds, have been isolated from the whole plants of Fatoua pilosa. The structures of these isolates were elucidated by means of spectroscopic techniques (UV, IR, MS, 1H- and 13C-NMR, DEPT, COSY, NOESY, HSQC, HMBC, and MS analyses). Among the tested compounds 2-14, scopoletin (3), isobavachalcone (12), and (E)-1-[2,4-dihydroxy-3-(3-methylbut-2-enyl)phenyl]-3-(2,2-dimethyl-8-hydroxy-2H-benzopyran-6-yl)prop-2-en-1-one (14) exhibited the strongest antimycobacterial activities against Mycobacterium tuberculosis H(37)Rv, with MIC values of 42, 18, and 30 microg/ml, respectively.

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Publisher Full Text (DOI)

Authors+Show Affiliations

Chiang CC
Graduate Institute of Natural Products, College of Pharmacy, Kaohsiung Medical University, Kaohsiung, Taiwan 807, R.O.C.
Cheng MJ
No affiliation info available
Peng CF
No affiliation info available
Huang HY
No affiliation info available
Chen IS
No affiliation info available

MeSH

Antitubercular AgentsCoumarinsHumansMicrobial Sensitivity TestsModels, MolecularMoraceaeMycobacterium tuberculosisTuberculosis

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

20658660

Citation

Chiang, Chun-Ching, et al. "A Novel Dimeric Coumarin Analog and Antimycobacterial Constituents From Fatoua Pilosa." Chemistry & Biodiversity, vol. 7, no. 7, 2010, pp. 1728-36.
Chiang CC, Cheng MJ, Peng CF, et al. A novel dimeric coumarin analog and antimycobacterial constituents from Fatoua pilosa. Chem Biodivers. 2010;7(7):1728-36.
Chiang, C. C., Cheng, M. J., Peng, C. F., Huang, H. Y., & Chen, I. S. (2010). A novel dimeric coumarin analog and antimycobacterial constituents from Fatoua pilosa. Chemistry & Biodiversity, 7(7), 1728-36. https://doi.org/10.1002/cbdv.200900326
Chiang CC, et al. A Novel Dimeric Coumarin Analog and Antimycobacterial Constituents From Fatoua Pilosa. Chem Biodivers. 2010;7(7):1728-36. PubMed PMID: 20658660.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - A novel dimeric coumarin analog and antimycobacterial constituents from Fatoua pilosa. AU - Chiang,Chun-Ching, AU - Cheng,Ming-Jen, AU - Peng,Chien-Fang, AU - Huang,Hung-Yi, AU - Chen,Ih-Sheng, PY - 2010/7/27/entrez PY - 2010/7/27/pubmed PY - 2010/12/14/medline SP - 1728 EP - 36 JF - Chemistry & biodiversity JO - Chem Biodivers VL - 7 IS - 7 N2 - One novel dimeric coumarin analog, fatouapilosin (1), together with 18 known compounds, have been isolated from the whole plants of Fatoua pilosa. The structures of these isolates were elucidated by means of spectroscopic techniques (UV, IR, MS, 1H- and 13C-NMR, DEPT, COSY, NOESY, HSQC, HMBC, and MS analyses). Among the tested compounds 2-14, scopoletin (3), isobavachalcone (12), and (E)-1-[2,4-dihydroxy-3-(3-methylbut-2-enyl)phenyl]-3-(2,2-dimethyl-8-hydroxy-2H-benzopyran-6-yl)prop-2-en-1-one (14) exhibited the strongest antimycobacterial activities against Mycobacterium tuberculosis H(37)Rv, with MIC values of 42, 18, and 30 microg/ml, respectively. SN - 1612-1880 UR - https://www.unboundmedicine.com/medline/citation/20658660/A_novel_dimeric_coumarin_analog_and_antimycobacterial_constituents_from_Fatoua_pilosa_ L2 - https://doi.org/10.1002/cbdv.200900326 DB - PRIME DP - Unbound Medicine ER -