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Greater arterial stiffness in polycystic ovary syndrome (PCOS) is an obesity--but not a PCOS-associated phenomenon.
J Clin Endocrinol Metab. 2010 Oct; 95(10):4566-75.JC

Abstract

CONTEXT

Polycystic ovary syndrome (PCOS) and obesity are associated with cardiovascular disease, but it is unclear to what extent they contribute independently. Arterial stiffness might link obesity and PCOS to cardiovascular diseases.

OBJECTIVE

Our objective was to investigate whether PCOS in the presence or absence of obesity is linked with arterial stiffness.

DESIGN AND SETTING

We conducted a cross-sectional study, including 31 obese (18 with PCOS) and 39 lean (22 with PCOS) women.

INTERVENTIONS AND MAIN OUTCOME MEASURES

Estimates of arterial stiffness were obtained by ultrasonography (distensibility and compliance of carotid, femoral, and brachial arteries; carotid elastic modulus; and intima-media thickness) and pulse wave transit time analyses (carotid-femoral pulse wave velocity and aortic augmentation index).

RESULTS

Obese women, with or without PCOS, had stiffer arteries than lean women. After adjustment for 24-h mean arterial pressure and age, obesity was inversely associated with the femoral, brachial, and carotid distensibility coefficients [β (95% confidence interval), -0.354 (-0.614 to -0.094), -0.354 (-0.547 to -0.161), and -0.248 (-0.370 to -0.126) 10(-3)/kPA, respectively] and with the femoral and carotid compliance coefficients [-0.296 (-0.563 to -0.029) and -0.190 (-0.377 to -0.003) mm(2)/kPA, respectively] but not with the brachial compliance coefficient [-0.018 (-0.052-0.015) mm(2)/kPA], Young's elastic modulus [0.049 (-0.005-0.103) kPA], aortic pulse wave velocity and aortic augmentation index [0.050 msec (-0.959-1.058 msec) and -1.831% (-8.196-4.534%), respectively]. Analyses with waist circumference as key independent variable gave broadly similar results. In contrast, PCOS was not associated with arterial stiffness estimates after adjustment for the presence of obesity.

CONCLUSIONS

In young obese women with PCOS, (central) obesity, rather than PCOS itself, is associated with increased arterial stiffness. These data emphasize that, from the perspective of cardiovascular risk reduction, the focus should be on central fat mass reduction in obese women with PCOS.

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Authors+Show Affiliations

Ketel IJ
Division of Reproductive Medicine, Department of Obstetrics and Gynecology, Vrije Universiteit Medical Centre (VU), Amsterdam, The Netherlands. ijg.ketel@vumc.nl
Stehouwer CD
No affiliation info available
Henry RM
No affiliation info available
Serné EH
No affiliation info available
Hompes P
No affiliation info available
Homburg R
No affiliation info available
Smulders YM
No affiliation info available
Lambalk CB
No affiliation info available

MeSH

AdultAortaArteriesBrachial ArteryCardiovascular DiseasesCase-Control StudiesCross-Sectional StudiesFemaleHumansObesityPolycystic Ovary SyndromeUltrasonographyVascular ResistanceYoung Adult

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

20660051

Citation

Ketel, I J., et al. "Greater Arterial Stiffness in Polycystic Ovary Syndrome (PCOS) Is an Obesity--but Not a PCOS-associated Phenomenon." The Journal of Clinical Endocrinology and Metabolism, vol. 95, no. 10, 2010, pp. 4566-75.
Ketel IJ, Stehouwer CD, Henry RM, et al. Greater arterial stiffness in polycystic ovary syndrome (PCOS) is an obesity--but not a PCOS-associated phenomenon. J Clin Endocrinol Metab. 2010;95(10):4566-75.
Ketel, I. J., Stehouwer, C. D., Henry, R. M., Serné, E. H., Hompes, P., Homburg, R., Smulders, Y. M., & Lambalk, C. B. (2010). Greater arterial stiffness in polycystic ovary syndrome (PCOS) is an obesity--but not a PCOS-associated phenomenon. The Journal of Clinical Endocrinology and Metabolism, 95(10), 4566-75. https://doi.org/10.1210/jc.2010-0868
Ketel IJ, et al. Greater Arterial Stiffness in Polycystic Ovary Syndrome (PCOS) Is an Obesity--but Not a PCOS-associated Phenomenon. J Clin Endocrinol Metab. 2010;95(10):4566-75. PubMed PMID: 20660051.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Greater arterial stiffness in polycystic ovary syndrome (PCOS) is an obesity--but not a PCOS-associated phenomenon. AU - Ketel,I J, AU - Stehouwer,C D, AU - Henry,R M, AU - Serné,E H, AU - Hompes,P, AU - Homburg,R, AU - Smulders,Y M, AU - Lambalk,C B, Y1 - 2010/07/21/ PY - 2010/7/28/entrez PY - 2010/7/28/pubmed PY - 2010/11/16/medline SP - 4566 EP - 75 JF - The Journal of clinical endocrinology and metabolism JO - J Clin Endocrinol Metab VL - 95 IS - 10 N2 - CONTEXT: Polycystic ovary syndrome (PCOS) and obesity are associated with cardiovascular disease, but it is unclear to what extent they contribute independently. Arterial stiffness might link obesity and PCOS to cardiovascular diseases. OBJECTIVE: Our objective was to investigate whether PCOS in the presence or absence of obesity is linked with arterial stiffness. DESIGN AND SETTING: We conducted a cross-sectional study, including 31 obese (18 with PCOS) and 39 lean (22 with PCOS) women. INTERVENTIONS AND MAIN OUTCOME MEASURES: Estimates of arterial stiffness were obtained by ultrasonography (distensibility and compliance of carotid, femoral, and brachial arteries; carotid elastic modulus; and intima-media thickness) and pulse wave transit time analyses (carotid-femoral pulse wave velocity and aortic augmentation index). RESULTS: Obese women, with or without PCOS, had stiffer arteries than lean women. After adjustment for 24-h mean arterial pressure and age, obesity was inversely associated with the femoral, brachial, and carotid distensibility coefficients [β (95% confidence interval), -0.354 (-0.614 to -0.094), -0.354 (-0.547 to -0.161), and -0.248 (-0.370 to -0.126) 10(-3)/kPA, respectively] and with the femoral and carotid compliance coefficients [-0.296 (-0.563 to -0.029) and -0.190 (-0.377 to -0.003) mm(2)/kPA, respectively] but not with the brachial compliance coefficient [-0.018 (-0.052-0.015) mm(2)/kPA], Young's elastic modulus [0.049 (-0.005-0.103) kPA], aortic pulse wave velocity and aortic augmentation index [0.050 msec (-0.959-1.058 msec) and -1.831% (-8.196-4.534%), respectively]. Analyses with waist circumference as key independent variable gave broadly similar results. In contrast, PCOS was not associated with arterial stiffness estimates after adjustment for the presence of obesity. CONCLUSIONS: In young obese women with PCOS, (central) obesity, rather than PCOS itself, is associated with increased arterial stiffness. These data emphasize that, from the perspective of cardiovascular risk reduction, the focus should be on central fat mass reduction in obese women with PCOS. SN - 1945-7197 UR - https://www.unboundmedicine.com/medline/citation/20660051/Greater_arterial_stiffness_in_polycystic_ovary_syndrome__PCOS__is_an_obesity__but_not_a_PCOS_associated_phenomenon_ L2 - https://academic.oup.com/jcem/article-lookup/doi/10.1210/jc.2010-0868 DB - PRIME DP - Unbound Medicine ER -