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Efficacy of antioxidant vitamins and selenium supplement in prostate cancer prevention: a meta-analysis of randomized controlled trials.
Nutr Cancer. 2010; 62(6):719-27.NC

Abstract

Several studies have evaluated the possible association between antioxidants vitamins or selenium supplement and the risk of prostate cancer, but the evidence is still inconsistent. We systematically searched PubMed, EMBASE, the Cochrane Library, Science Citation Index Expanded, Chinese biomedicine literature database, and bibliographies of retrieved articles up to January 2009. We included 9 randomized controlled trials with 165,056 participants; methodological quality of included trials was generally high. Meta-analysis showed that no significant effects of supplementation with beta-carotene (RR 0.97, 95% CI 0.90-1.05) (3 trials), vitamin C (RR 0.98, 95% CI 0.91-1.06) (2 trials), vitamin E (RR 0.96, 95% CI 0.85-1.08) (5 trials), and selenium (RR 0.78, 95% CI 0.41-1.48) (2 trials)versus placebo on prostate cancer incidence. The mortality of prostate cancer did not differ significantly by supplement of beta-carotene (RR 1.19, 95% CI 0.87 -1.65) (1 trial), vitamin C (RR 1.45, 95%CI 0.92-2.29) (1 trial), vitamin E (RR 0.85, 95%CI 0.58-1.24) (2 trials), and selenium (RR 2.98, 95% CI 0.12-73.16) (1 trial). Our findings indicate that antioxidant vitamins and selenium supplement did not reduce the incidence and mortality of prostate cancer, these data provide no support for the use of these supplements for the prevention of prostate cancer.

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Authors+Show Affiliations

Jiang L
The First Hospital of Lanzhou University, 199 Donggang West Road, Chengguan District, Lanzhou, Gansu, China.
Yang KH
No affiliation info available
Tian JH
No affiliation info available
Guan QL
No affiliation info available
Yao N
No affiliation info available
Cao N
No affiliation info available
Mi DH
No affiliation info available
Wu J
No affiliation info available
Ma B
No affiliation info available
Yang SH
No affiliation info available

MeSH

AdultAgedAntioxidantsAscorbic AcidDietary SupplementsHumansMaleMiddle AgedProstatic NeoplasmsRandomized Controlled Trials as TopicSeleniumVitamin Ebeta Carotene

Pub Type(s)

Journal Article
Meta-Analysis

Language

eng

PubMed ID

20661819

Citation

Jiang, Lei, et al. "Efficacy of Antioxidant Vitamins and Selenium Supplement in Prostate Cancer Prevention: a Meta-analysis of Randomized Controlled Trials." Nutrition and Cancer, vol. 62, no. 6, 2010, pp. 719-27.
Jiang L, Yang KH, Tian JH, et al. Efficacy of antioxidant vitamins and selenium supplement in prostate cancer prevention: a meta-analysis of randomized controlled trials. Nutr Cancer. 2010;62(6):719-27.
Jiang, L., Yang, K. H., Tian, J. H., Guan, Q. L., Yao, N., Cao, N., Mi, D. H., Wu, J., Ma, B., & Yang, S. H. (2010). Efficacy of antioxidant vitamins and selenium supplement in prostate cancer prevention: a meta-analysis of randomized controlled trials. Nutrition and Cancer, 62(6), 719-27. https://doi.org/10.1080/01635581.2010.494335
Jiang L, et al. Efficacy of Antioxidant Vitamins and Selenium Supplement in Prostate Cancer Prevention: a Meta-analysis of Randomized Controlled Trials. Nutr Cancer. 2010;62(6):719-27. PubMed PMID: 20661819.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Efficacy of antioxidant vitamins and selenium supplement in prostate cancer prevention: a meta-analysis of randomized controlled trials. AU - Jiang,Lei, AU - Yang,Ke-hu, AU - Tian,Jin-hui, AU - Guan,Quan-lin, AU - Yao,Nan, AU - Cao,Nong, AU - Mi,Deng-hai, AU - Wu,Jie, AU - Ma,Bin, AU - Yang,Sun-hu, PY - 2010/7/28/entrez PY - 2010/7/28/pubmed PY - 2010/12/14/medline SP - 719 EP - 27 JF - Nutrition and cancer JO - Nutr Cancer VL - 62 IS - 6 N2 - Several studies have evaluated the possible association between antioxidants vitamins or selenium supplement and the risk of prostate cancer, but the evidence is still inconsistent. We systematically searched PubMed, EMBASE, the Cochrane Library, Science Citation Index Expanded, Chinese biomedicine literature database, and bibliographies of retrieved articles up to January 2009. We included 9 randomized controlled trials with 165,056 participants; methodological quality of included trials was generally high. Meta-analysis showed that no significant effects of supplementation with beta-carotene (RR 0.97, 95% CI 0.90-1.05) (3 trials), vitamin C (RR 0.98, 95% CI 0.91-1.06) (2 trials), vitamin E (RR 0.96, 95% CI 0.85-1.08) (5 trials), and selenium (RR 0.78, 95% CI 0.41-1.48) (2 trials)versus placebo on prostate cancer incidence. The mortality of prostate cancer did not differ significantly by supplement of beta-carotene (RR 1.19, 95% CI 0.87 -1.65) (1 trial), vitamin C (RR 1.45, 95%CI 0.92-2.29) (1 trial), vitamin E (RR 0.85, 95%CI 0.58-1.24) (2 trials), and selenium (RR 2.98, 95% CI 0.12-73.16) (1 trial). Our findings indicate that antioxidant vitamins and selenium supplement did not reduce the incidence and mortality of prostate cancer, these data provide no support for the use of these supplements for the prevention of prostate cancer. SN - 1532-7914 UR - https://www.unboundmedicine.com/medline/citation/20661819/Efficacy_of_antioxidant_vitamins_and_selenium_supplement_in_prostate_cancer_prevention:_a_meta_analysis_of_randomized_controlled_trials_ L2 - https://www.tandfonline.com/doi/full/10.1080/01635581.2010.494335 DB - PRIME DP - Unbound Medicine ER -