Tags

Type your tag names separated by a space and hit enter

Effect of dietary intake of isoflavones on the estrogen and progesterone receptor status of breast cancer.
Nutr Cancer. 2010; 62(6):765-73.NC

Abstract

To examine if higher intake of isoflavones prior to diagnosis was associated with a positive status of estrogen receptors (ER) and progesterone receptors (PR) in breast tumor tissue, a retrospective study was conducted in 2004 to 2005 in 756 Chinese women with histologically confirmed breast cancer. We administered a food frequency questionnaire by face-to-face interview to assess the intake of the isoflavones daidzein and genistein. Unconditional logistic regression analysis was used to estimate odds ratios (ORs) and 95% confidence intervals (CIs) adjusted for potential confounders. Comparing the highest to lowest intake quartiles, the adjusted ORs for daidzein were 1.94 (95% CI = 1.20-3.32) and 2.18 (95% CI = 1.28-3.73) for ER positive and PR positive tumors, respectively, in premenopausal patients. The ORs for both ER and PR positive status combined were 2.48 (95% CI = 1.37-4.49) for daidzein and 1.94 (95% CI = 1.21-3.14) for genistein in premenopausal patients with statistically significant tests for trend. There was little or no evidence of associations in postmenopausal patients. We conclude that higher intake of daidzein and genistein before diagnosis was associated with ER and PR positive status in premenopausal Chinese women with breast cancer. The association might confer a more favorable prognosis.

Authors+Show Affiliations

School of Population Health, The University of Western Australia, 35 Stirling Highway, Crawley, Perth, Western Australia 6009, Australia. min.zhang@uwa.edu.auNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

20661825

Citation

Zhang, Min, et al. "Effect of Dietary Intake of Isoflavones On the Estrogen and Progesterone Receptor Status of Breast Cancer." Nutrition and Cancer, vol. 62, no. 6, 2010, pp. 765-73.
Zhang M, Liu X, Holman CD. Effect of dietary intake of isoflavones on the estrogen and progesterone receptor status of breast cancer. Nutr Cancer. 2010;62(6):765-73.
Zhang, M., Liu, X., & Holman, C. D. (2010). Effect of dietary intake of isoflavones on the estrogen and progesterone receptor status of breast cancer. Nutrition and Cancer, 62(6), 765-73. https://doi.org/10.1080/01635581003605979
Zhang M, Liu X, Holman CD. Effect of Dietary Intake of Isoflavones On the Estrogen and Progesterone Receptor Status of Breast Cancer. Nutr Cancer. 2010;62(6):765-73. PubMed PMID: 20661825.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effect of dietary intake of isoflavones on the estrogen and progesterone receptor status of breast cancer. AU - Zhang,Min, AU - Liu,Xiaojiao, AU - Holman,C D'Arcy J, PY - 2010/7/28/entrez PY - 2010/7/28/pubmed PY - 2010/12/14/medline SP - 765 EP - 73 JF - Nutrition and cancer JO - Nutr Cancer VL - 62 IS - 6 N2 - To examine if higher intake of isoflavones prior to diagnosis was associated with a positive status of estrogen receptors (ER) and progesterone receptors (PR) in breast tumor tissue, a retrospective study was conducted in 2004 to 2005 in 756 Chinese women with histologically confirmed breast cancer. We administered a food frequency questionnaire by face-to-face interview to assess the intake of the isoflavones daidzein and genistein. Unconditional logistic regression analysis was used to estimate odds ratios (ORs) and 95% confidence intervals (CIs) adjusted for potential confounders. Comparing the highest to lowest intake quartiles, the adjusted ORs for daidzein were 1.94 (95% CI = 1.20-3.32) and 2.18 (95% CI = 1.28-3.73) for ER positive and PR positive tumors, respectively, in premenopausal patients. The ORs for both ER and PR positive status combined were 2.48 (95% CI = 1.37-4.49) for daidzein and 1.94 (95% CI = 1.21-3.14) for genistein in premenopausal patients with statistically significant tests for trend. There was little or no evidence of associations in postmenopausal patients. We conclude that higher intake of daidzein and genistein before diagnosis was associated with ER and PR positive status in premenopausal Chinese women with breast cancer. The association might confer a more favorable prognosis. SN - 1532-7914 UR - https://www.unboundmedicine.com/medline/citation/20661825/Effect_of_dietary_intake_of_isoflavones_on_the_estrogen_and_progesterone_receptor_status_of_breast_cancer_ L2 - http://www.tandfonline.com/doi/full/10.1080/01635581003605979 DB - PRIME DP - Unbound Medicine ER -