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Clinical correlates of Panton-Valentine leukocidin (PVL), PVL isoforms, and clonal complex in the Staphylococcus aureus population of Northern Australia.
J Infect Dis. 2010 Sep 01; 202(5):760-9.JI

Abstract

BACKGROUND

Regional differences in the prevalence of Panton-Valentine leukocidin (PVL) and PVL isoform-harboring strains as well as in the local population structure of Staphylococcus aureus may influence the clinical spectrum of S. aureus infections.

METHODS

Using a prospective collection of S. aureus isolates from northern Australia, we determined differences between infections caused by (1) PVL(+) and PVL(-) isolates, (2) PVL histidine (H) isoform- and PVL arginine (R) isoform-harboring isolates, and (3) different lineages, including the genetically divergent clonal complex (CC) 75 and the PVL(+) CC93.

RESULTS

PVL(+) isolates comprised 54% (128/239) of community-associated methicillin-resistant isolates and 40% (95/239) of methicillin-susceptible S. aureus (MSSA) isolates. There were 113 H isoform- and 110 R isoform-harboring isolates. PVL was associated with truly community-acquired disease, younger age, and presentation with sepsis. We found no differences in infections due to H isoform-harboring isolates, compared with R isoform-harboring isolates. CC93 was the most prevalent lineage. The genetically divergent CC75 caused clinical disease similar to that of other S. aureus clones.

CONCLUSIONS

PVL(+) and PVL(-) infections are clearly distinct. MSSA contributes a large but underrecognized burden of PVL(+) disease. Compared with elsewhere in the world, there is a relative abundance of the clade that contains CC93 and CC121 in both northern Australia and Asia.

Authors+Show Affiliations

Menzies School of Health Research, Charles Darwin University, Darwin, Australia. steven.tong@menzies.edu.auNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

20662623

Citation

Tong, Steven Y C., et al. "Clinical Correlates of Panton-Valentine Leukocidin (PVL), PVL Isoforms, and Clonal Complex in the Staphylococcus Aureus Population of Northern Australia." The Journal of Infectious Diseases, vol. 202, no. 5, 2010, pp. 760-9.
Tong SY, Lilliebridge RA, Bishop EJ, et al. Clinical correlates of Panton-Valentine leukocidin (PVL), PVL isoforms, and clonal complex in the Staphylococcus aureus population of Northern Australia. J Infect Dis. 2010;202(5):760-9.
Tong, S. Y., Lilliebridge, R. A., Bishop, E. J., Cheng, A. C., Holt, D. C., McDonald, M. I., Giffard, P. M., Currie, B. J., & Boutlis, C. S. (2010). Clinical correlates of Panton-Valentine leukocidin (PVL), PVL isoforms, and clonal complex in the Staphylococcus aureus population of Northern Australia. The Journal of Infectious Diseases, 202(5), 760-9. https://doi.org/10.1086/655396
Tong SY, et al. Clinical Correlates of Panton-Valentine Leukocidin (PVL), PVL Isoforms, and Clonal Complex in the Staphylococcus Aureus Population of Northern Australia. J Infect Dis. 2010 Sep 1;202(5):760-9. PubMed PMID: 20662623.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Clinical correlates of Panton-Valentine leukocidin (PVL), PVL isoforms, and clonal complex in the Staphylococcus aureus population of Northern Australia. AU - Tong,Steven Y C, AU - Lilliebridge,Rachael A, AU - Bishop,Emma J, AU - Cheng,Allen C, AU - Holt,Deborah C, AU - McDonald,Malcolm I, AU - Giffard,Philip M, AU - Currie,Bart J, AU - Boutlis,Craig S, PY - 2010/7/29/entrez PY - 2010/7/29/pubmed PY - 2010/9/3/medline SP - 760 EP - 9 JF - The Journal of infectious diseases JO - J Infect Dis VL - 202 IS - 5 N2 - BACKGROUND: Regional differences in the prevalence of Panton-Valentine leukocidin (PVL) and PVL isoform-harboring strains as well as in the local population structure of Staphylococcus aureus may influence the clinical spectrum of S. aureus infections. METHODS: Using a prospective collection of S. aureus isolates from northern Australia, we determined differences between infections caused by (1) PVL(+) and PVL(-) isolates, (2) PVL histidine (H) isoform- and PVL arginine (R) isoform-harboring isolates, and (3) different lineages, including the genetically divergent clonal complex (CC) 75 and the PVL(+) CC93. RESULTS: PVL(+) isolates comprised 54% (128/239) of community-associated methicillin-resistant isolates and 40% (95/239) of methicillin-susceptible S. aureus (MSSA) isolates. There were 113 H isoform- and 110 R isoform-harboring isolates. PVL was associated with truly community-acquired disease, younger age, and presentation with sepsis. We found no differences in infections due to H isoform-harboring isolates, compared with R isoform-harboring isolates. CC93 was the most prevalent lineage. The genetically divergent CC75 caused clinical disease similar to that of other S. aureus clones. CONCLUSIONS: PVL(+) and PVL(-) infections are clearly distinct. MSSA contributes a large but underrecognized burden of PVL(+) disease. Compared with elsewhere in the world, there is a relative abundance of the clade that contains CC93 and CC121 in both northern Australia and Asia. SN - 1537-6613 UR - https://www.unboundmedicine.com/medline/citation/20662623/Clinical_correlates_of_Panton_Valentine_leukocidin__PVL__PVL_isoforms_and_clonal_complex_in_the_Staphylococcus_aureus_population_of_Northern_Australia_ DB - PRIME DP - Unbound Medicine ER -