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Analysis of the serum levels of fungi-specific immunoglobulin E in patients with allergic diseases.
Int Arch Allergy Immunol. 2011; 154(1):49-56.IA

Abstract

BACKGROUND

Atopic patients are exceptionally sensitive to airborne allergens. Sensitization to fungal allergens may be associated with respiratory allergic disease (RAD) and atopic dermatitis (AD). This study investigates the relationship between sensitization to different fungal allergens and the clinical manifestations of atopic disease.

METHODS

We retrospectively reviewed the medical records of atopic patients from the National Taiwan University Hospital from 2004 to 2009. A total of 133 atopic patients were found who were sensitive to at least 1 of the 3 most common fungi (Candida albicans, Aspergillus fumigatus, Penicillium chrysogenum) in Taiwan and were enrolled in the study. These patients were further divided into subgroups of isolated AD, isolated RAD and AD + RAD. The association between sensitization to fungi and allergic disease was analyzed by logistic regression analysis.

RESULTS

The sensitization rate to Candida-specific IgE was 81.2%, followed closely by Aspergillus at 69.2% and Penicillium at 63.2%. Isolated AD was the most common diagnosis. The levels of specific IgE antibodies against Aspergillus, Candida and Penicillium were highest in patients with isolated AD. Logistic regression revealed that isolated AD was highly associated with sensitization to Candida [odds ratio (OR) 10.45, 95% confidence interval (CI) 2.37-45.9]. In contrast, sensitization to Penicillium (OR 0.34, 95% CI 0.13-0.87)and Candida (OR 0.30, 95% CI 0.10-0.92) showed a negative association with isolated RAD.

CONCLUSIONS

Fungal sensitization is more closely associated with AD than RAD. Our results suggest that specific sensitization to fungal allergens plays a critical role in the pathogenesis of atopic disease.

Authors+Show Affiliations

Department of Pediatrics, Shin Kong Wu Ho-Su Memorial Hospital, 7 Chung-Shan South Road, Taipei, Taiwan, Republic of China.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

20664277

Citation

Chang, Feng-Ying, et al. "Analysis of the Serum Levels of Fungi-specific Immunoglobulin E in Patients With Allergic Diseases." International Archives of Allergy and Immunology, vol. 154, no. 1, 2011, pp. 49-56.
Chang FY, Lee JH, Yang YH, et al. Analysis of the serum levels of fungi-specific immunoglobulin E in patients with allergic diseases. Int Arch Allergy Immunol. 2011;154(1):49-56.
Chang, F. Y., Lee, J. H., Yang, Y. H., Yu, H. H., Wang, L. C., Lin, Y. T., & Chiang, B. L. (2011). Analysis of the serum levels of fungi-specific immunoglobulin E in patients with allergic diseases. International Archives of Allergy and Immunology, 154(1), 49-56. https://doi.org/10.1159/000319208
Chang FY, et al. Analysis of the Serum Levels of Fungi-specific Immunoglobulin E in Patients With Allergic Diseases. Int Arch Allergy Immunol. 2011;154(1):49-56. PubMed PMID: 20664277.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Analysis of the serum levels of fungi-specific immunoglobulin E in patients with allergic diseases. AU - Chang,Feng-Ying, AU - Lee,Jyh-Hong, AU - Yang,Yao-Hsu, AU - Yu,Hsin-Hui, AU - Wang,Li-Chieh, AU - Lin,Yu-Tsan, AU - Chiang,Bor-Luen, Y1 - 2010/07/27/ PY - 2009/06/08/received PY - 2009/11/27/accepted PY - 2010/7/29/entrez PY - 2010/7/29/pubmed PY - 2011/1/11/medline SP - 49 EP - 56 JF - International archives of allergy and immunology JO - Int Arch Allergy Immunol VL - 154 IS - 1 N2 - BACKGROUND: Atopic patients are exceptionally sensitive to airborne allergens. Sensitization to fungal allergens may be associated with respiratory allergic disease (RAD) and atopic dermatitis (AD). This study investigates the relationship between sensitization to different fungal allergens and the clinical manifestations of atopic disease. METHODS: We retrospectively reviewed the medical records of atopic patients from the National Taiwan University Hospital from 2004 to 2009. A total of 133 atopic patients were found who were sensitive to at least 1 of the 3 most common fungi (Candida albicans, Aspergillus fumigatus, Penicillium chrysogenum) in Taiwan and were enrolled in the study. These patients were further divided into subgroups of isolated AD, isolated RAD and AD + RAD. The association between sensitization to fungi and allergic disease was analyzed by logistic regression analysis. RESULTS: The sensitization rate to Candida-specific IgE was 81.2%, followed closely by Aspergillus at 69.2% and Penicillium at 63.2%. Isolated AD was the most common diagnosis. The levels of specific IgE antibodies against Aspergillus, Candida and Penicillium were highest in patients with isolated AD. Logistic regression revealed that isolated AD was highly associated with sensitization to Candida [odds ratio (OR) 10.45, 95% confidence interval (CI) 2.37-45.9]. In contrast, sensitization to Penicillium (OR 0.34, 95% CI 0.13-0.87)and Candida (OR 0.30, 95% CI 0.10-0.92) showed a negative association with isolated RAD. CONCLUSIONS: Fungal sensitization is more closely associated with AD than RAD. Our results suggest that specific sensitization to fungal allergens plays a critical role in the pathogenesis of atopic disease. SN - 1423-0097 UR - https://www.unboundmedicine.com/medline/citation/20664277/Analysis_of_the_serum_levels_of_fungi_specific_immunoglobulin_E_in_patients_with_allergic_diseases_ L2 - https://www.karger.com?DOI=10.1159/000319208 DB - PRIME DP - Unbound Medicine ER -