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Coffee and endothelial function: a battle between caffeine and antioxidants?
Eur J Clin Nutr 2010; 64(10):1242-3EJ

Abstract

Although coffee is largely consumed by adults in Western countries, controversy exists about its impact on the cardiovascular system. We recently demonstrated that caffeinated and decaffeinated espresso coffee have different acute effects on endothelial function in healthy subjects, measured using flow-mediated dilation (FMD) of the brachial artery. In this study, we measured the anti-oxidant capacity of two coffee substances in terms of free stable radical 2,2-diphenyl-1-picryl-hydrazyl 50% inhibition (I(50) DPPH). The caffeinated coffee had a slightly higher anti-oxidant capacity than decaffeinated espresso coffee (I(50) DPPH: 1.13±0.02 vs 1.30±0.03 μl; P<0.001). We suggest that the unfavourable effects observed after caffeinated coffee ingestion are due to caffeine and that the antioxidant activity is responsible for the increased FMD observed after decaffeinated coffee ingestion. Further clinical and epidemiological studies are needed to understand the chronic effects of coffee consumption on health.

Authors+Show Affiliations

Dipartimento di Medicina Interna, Malattie Cardiovascolari e NefroUrologiche, Facoltà di Medicina, University of Palermo, Palermo, Italy. silbus@tin.itNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

20664622

Citation

Buscemi, S, et al. "Coffee and Endothelial Function: a Battle Between Caffeine and Antioxidants?" European Journal of Clinical Nutrition, vol. 64, no. 10, 2010, pp. 1242-3.
Buscemi S, Batsis JA, Arcoleo G, et al. Coffee and endothelial function: a battle between caffeine and antioxidants? Eur J Clin Nutr. 2010;64(10):1242-3.
Buscemi, S., Batsis, J. A., Arcoleo, G., & Verga, S. (2010). Coffee and endothelial function: a battle between caffeine and antioxidants? European Journal of Clinical Nutrition, 64(10), pp. 1242-3. doi:10.1038/ejcn.2010.137.
Buscemi S, et al. Coffee and Endothelial Function: a Battle Between Caffeine and Antioxidants. Eur J Clin Nutr. 2010;64(10):1242-3. PubMed PMID: 20664622.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Coffee and endothelial function: a battle between caffeine and antioxidants? AU - Buscemi,S, AU - Batsis,J A, AU - Arcoleo,G, AU - Verga,S, Y1 - 2010/07/28/ PY - 2010/7/29/entrez PY - 2010/7/29/pubmed PY - 2011/2/15/medline SP - 1242 EP - 3 JF - European journal of clinical nutrition JO - Eur J Clin Nutr VL - 64 IS - 10 N2 - Although coffee is largely consumed by adults in Western countries, controversy exists about its impact on the cardiovascular system. We recently demonstrated that caffeinated and decaffeinated espresso coffee have different acute effects on endothelial function in healthy subjects, measured using flow-mediated dilation (FMD) of the brachial artery. In this study, we measured the anti-oxidant capacity of two coffee substances in terms of free stable radical 2,2-diphenyl-1-picryl-hydrazyl 50% inhibition (I(50) DPPH). The caffeinated coffee had a slightly higher anti-oxidant capacity than decaffeinated espresso coffee (I(50) DPPH: 1.13±0.02 vs 1.30±0.03 μl; P<0.001). We suggest that the unfavourable effects observed after caffeinated coffee ingestion are due to caffeine and that the antioxidant activity is responsible for the increased FMD observed after decaffeinated coffee ingestion. Further clinical and epidemiological studies are needed to understand the chronic effects of coffee consumption on health. SN - 1476-5640 UR - https://www.unboundmedicine.com/medline/citation/20664622/Coffee_and_endothelial_function:_a_battle_between_caffeine_and_antioxidants L2 - http://dx.doi.org/10.1038/ejcn.2010.137 DB - PRIME DP - Unbound Medicine ER -