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Relationship between dietary vitamin K intake and the stability of anticoagulation effect in patients taking long-term warfarin.
Thromb Haemost. 2010 Oct; 104(4):755-9.TH

Abstract

Little study has been performed on the effect of vitamin K intake on the variability of warfarin's anticoagulant effects over long period of time. We estimated average vitamin K intake in the patients taking warfarin and evaluated its relation with the stability of anticoagulation effect. We estimated average daily vitamin K intake based on a three-day food diary in 66 patients taking warfarin regularly for ≥ one year and divided them into three groups of equal number according to vitamin K intake. Stability of anticoagulant effect was compared in these groups using the coefficient of variation (CV) of the prothrombin time expressed in international normalised ratio (INR) and the CV of warfarin doses. Median daily vitamin K intake was 161.3 μg/day (31.3 μg/day - 616.6 μg/day). CVs of both INR and warfarin doses were negatively and independently correlated with dietary vitamin K intake (r=-0.293, p=0.017 and r= -0.350, p=0.004, respectively). CV of INR was significantly different among three groups of vitamin K intake (p<0.05 in ANOVA). High vitamin K intake (>195.7 μg/day) group had lower CV of INR than the low intake (<126.5 μg/day) group (19.2 ± 8.96 % vs. 25.5 ± 8.61 %, p<0.05). CV of warfarin doses was also significantly different among the groups (p<0.05 in Jonckheere-Terpstra test). However, the significance of difference between high and low vitamin intake groups was marginal (p=0.046 in Mann-Whitney test). In conclusion, long-term anticoagulation effect of warfarin is more stable in the patients who take greater than a certain amount of dietary vitamin K.

Authors+Show Affiliations

Department of Internal Medicine, Kyungpook National University Hospital, Daegu, Republic of Korea.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

20664899

Citation

Kim, Kyun Hee, et al. "Relationship Between Dietary Vitamin K Intake and the Stability of Anticoagulation Effect in Patients Taking Long-term Warfarin." Thrombosis and Haemostasis, vol. 104, no. 4, 2010, pp. 755-9.
Kim KH, Choi WS, Lee JH, et al. Relationship between dietary vitamin K intake and the stability of anticoagulation effect in patients taking long-term warfarin. Thromb Haemost. 2010;104(4):755-9.
Kim, K. H., Choi, W. S., Lee, J. H., Lee, H., Yang, D. H., & Chae, S. C. (2010). Relationship between dietary vitamin K intake and the stability of anticoagulation effect in patients taking long-term warfarin. Thrombosis and Haemostasis, 104(4), 755-9. https://doi.org/10.1160/TH10-04-0257
Kim KH, et al. Relationship Between Dietary Vitamin K Intake and the Stability of Anticoagulation Effect in Patients Taking Long-term Warfarin. Thromb Haemost. 2010;104(4):755-9. PubMed PMID: 20664899.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Relationship between dietary vitamin K intake and the stability of anticoagulation effect in patients taking long-term warfarin. AU - Kim,Kyun Hee, AU - Choi,Won Suk, AU - Lee,Jang Hoon, AU - Lee,Hyejin, AU - Yang,Dong Heon, AU - Chae,Shung Chull, Y1 - 2010/07/20/ PY - 2010/04/28/received PY - 2010/06/04/accepted PY - 2010/7/29/entrez PY - 2010/7/29/pubmed PY - 2011/5/12/medline SP - 755 EP - 9 JF - Thrombosis and haemostasis JO - Thromb Haemost VL - 104 IS - 4 N2 - Little study has been performed on the effect of vitamin K intake on the variability of warfarin's anticoagulant effects over long period of time. We estimated average vitamin K intake in the patients taking warfarin and evaluated its relation with the stability of anticoagulation effect. We estimated average daily vitamin K intake based on a three-day food diary in 66 patients taking warfarin regularly for ≥ one year and divided them into three groups of equal number according to vitamin K intake. Stability of anticoagulant effect was compared in these groups using the coefficient of variation (CV) of the prothrombin time expressed in international normalised ratio (INR) and the CV of warfarin doses. Median daily vitamin K intake was 161.3 μg/day (31.3 μg/day - 616.6 μg/day). CVs of both INR and warfarin doses were negatively and independently correlated with dietary vitamin K intake (r=-0.293, p=0.017 and r= -0.350, p=0.004, respectively). CV of INR was significantly different among three groups of vitamin K intake (p<0.05 in ANOVA). High vitamin K intake (>195.7 μg/day) group had lower CV of INR than the low intake (<126.5 μg/day) group (19.2 ± 8.96 % vs. 25.5 ± 8.61 %, p<0.05). CV of warfarin doses was also significantly different among the groups (p<0.05 in Jonckheere-Terpstra test). However, the significance of difference between high and low vitamin intake groups was marginal (p=0.046 in Mann-Whitney test). In conclusion, long-term anticoagulation effect of warfarin is more stable in the patients who take greater than a certain amount of dietary vitamin K. SN - 2567-689X UR - https://www.unboundmedicine.com/medline/citation/20664899/Relationship_between_dietary_vitamin_K_intake_and_the_stability_of_anticoagulation_effect_in_patients_taking_long_term_warfarin_ L2 - http://www.thieme-connect.com/DOI/DOI?10.1160/TH10-04-0257 DB - PRIME DP - Unbound Medicine ER -