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Evaluation of cadmium, chromium, nickel, and zinc in biological samples of psoriasis patients living in Pakistani cement factory area.
Biol Trace Elem Res 2011; 142(3):284-301BT

Abstract

Psoriasis is a noncontiguous common and chronic skin disorder. The aim of the present study was to compare the level of trace elements cadmium (Cd), chromium (Cr), Nickel (Ni), and zinc (Zn) in biological samples (whole blood, urine, and scalp hair) of psoriasis patients of both gender age ranged (25-55 years) at mild, moderate severe, and more severe stage (n = 418) living in the vicinity of cement factory. For comparison purposes, healthy age-matched referent subjects, residents of industrial and non-industrial area, of both gender were also selected (n = 241). The concentrations of trace and toxic elements were measured by atomic absorption spectrophotometer prior to microwave-assisted acid digestion. The validity and accuracy of methodology was checked by using certified reference materials (CRMs) and conventional wet acid digestion method on same CRMs and real samples. The results of this study showed that the mean values of Cd, Cr, Ni, and Pb were significantly higher in scalp hair, blood, and urine samples of mild and severe psoriasis patients as compared to referents (p < 0.001), while the concentration of Zn was lower in the scalp hair and blood, but higher in the urine samples of psoriasis patients. The deficiency of Zn in psoriasis patients may be undoubtedly caused by the toxic element exposures via cement factory.

Authors+Show Affiliations

National Center of Excellence in Analytical Chemistry, University of Sindh, Jamshoro 76080, Pakistan. hassanimranafridi@yahoo.comNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

20665125

Citation

Afridi, Hassan Imran, et al. "Evaluation of Cadmium, Chromium, Nickel, and Zinc in Biological Samples of Psoriasis Patients Living in Pakistani Cement Factory Area." Biological Trace Element Research, vol. 142, no. 3, 2011, pp. 284-301.
Afridi HI, Kazi TG, Kazi N, et al. Evaluation of cadmium, chromium, nickel, and zinc in biological samples of psoriasis patients living in Pakistani cement factory area. Biol Trace Elem Res. 2011;142(3):284-301.
Afridi, H. I., Kazi, T. G., Kazi, N., Kandhro, G. A., Baig, J. A., Shah, A. Q., ... Arain, M. B. (2011). Evaluation of cadmium, chromium, nickel, and zinc in biological samples of psoriasis patients living in Pakistani cement factory area. Biological Trace Element Research, 142(3), pp. 284-301. doi:10.1007/s12011-010-8778-y.
Afridi HI, et al. Evaluation of Cadmium, Chromium, Nickel, and Zinc in Biological Samples of Psoriasis Patients Living in Pakistani Cement Factory Area. Biol Trace Elem Res. 2011;142(3):284-301. PubMed PMID: 20665125.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Evaluation of cadmium, chromium, nickel, and zinc in biological samples of psoriasis patients living in Pakistani cement factory area. AU - Afridi,Hassan Imran, AU - Kazi,Tasneem Gul, AU - Kazi,Naveed, AU - Kandhro,Ghulam Abbas, AU - Baig,Jameel Ahmed, AU - Shah,Abdul Qadir, AU - Khan,Sumaira, AU - Kolachi,Nida Fatima, AU - Wadhwa,Sham Kumar, AU - Shah,Faheem, AU - Jamali,Mohammad Khan, AU - Arain,Mohammad Balal, Y1 - 2010/07/28/ PY - 2010/07/07/received PY - 2010/07/11/accepted PY - 2010/7/29/entrez PY - 2010/7/29/pubmed PY - 2012/1/24/medline SP - 284 EP - 301 JF - Biological trace element research JO - Biol Trace Elem Res VL - 142 IS - 3 N2 - Psoriasis is a noncontiguous common and chronic skin disorder. The aim of the present study was to compare the level of trace elements cadmium (Cd), chromium (Cr), Nickel (Ni), and zinc (Zn) in biological samples (whole blood, urine, and scalp hair) of psoriasis patients of both gender age ranged (25-55 years) at mild, moderate severe, and more severe stage (n = 418) living in the vicinity of cement factory. For comparison purposes, healthy age-matched referent subjects, residents of industrial and non-industrial area, of both gender were also selected (n = 241). The concentrations of trace and toxic elements were measured by atomic absorption spectrophotometer prior to microwave-assisted acid digestion. The validity and accuracy of methodology was checked by using certified reference materials (CRMs) and conventional wet acid digestion method on same CRMs and real samples. The results of this study showed that the mean values of Cd, Cr, Ni, and Pb were significantly higher in scalp hair, blood, and urine samples of mild and severe psoriasis patients as compared to referents (p < 0.001), while the concentration of Zn was lower in the scalp hair and blood, but higher in the urine samples of psoriasis patients. The deficiency of Zn in psoriasis patients may be undoubtedly caused by the toxic element exposures via cement factory. SN - 1559-0720 UR - https://www.unboundmedicine.com/medline/citation/20665125/Evaluation_of_cadmium_chromium_nickel_and_zinc_in_biological_samples_of_psoriasis_patients_living_in_Pakistani_cement_factory_area_ L2 - https://dx.doi.org/10.1007/s12011-010-8778-y DB - PRIME DP - Unbound Medicine ER -