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Higher parity and shorter breastfeeding duration: association with triple-negative phenotype of breast cancer.
Cancer. 2010 Nov 01; 116(21):4933-43.C

Abstract

BACKGROUND

The combination of increased parity and shorter breastfeeding duration might increase the odds of the least differentiated triple-negative breast cancer (BC) phenotype, theoretically because an expanded progenitor cell population from each pregnancy would incompletely differentiate postpartum.

METHODS

Subjects consisted of a consecutive case series of 2473 women treated for invasive breast cancer between 2001 and 2006. Breast cancer phenotype (triple-negative BC, vs non-triple-negative BC) was compared with reproductive and demographic information. Odds ratios (OR) with 95% confidence intervals (CIs) for the association of breastfeeding duration (months per child) and parity with triple-negative BC were calculated after adjusting for ethnicity, age at menarche, family history, and age at diagnosis.

RESULTS

Compared with non-triple-negative BC, triple-negative BC was associated with shorter duration of breastfeeding per child (OR, 0.93; 95% CI, 0.90-0.97) and with higher parity (OR, 1.12; 95% CI, 1.06-1.20). By using multivariate logistic regression, triple-negative BC was independently associated with higher parity (OR, 2.76 [95% CI, 1.86-4.08] if ≥3 live births; OR, 1.89 [95% CI, 1.30-2.74] if ≤2 live births vs nulliparae), breastfeeding duration (OR, 0.55 [95% CI, 0.41-0.74] if >2 mo/child and OR, 0.58 [95% CI, 0.42-0.82] if ≤2 mo/child vs none), African American ethnicity (OR, 2.10; 95% CI, 1.52-2.92), and younger age at diagnosis (OR, 3.02 [95% CI, 2.03-4.47] if ≤40 years vs >60 years).

CONCLUSIONS

Among women with invasive breast cancer, higher parity and the absence or short duration of breastfeeding were independently associated with triple-negative BC. Any duration of breastfeeding was found to be associated with lower probability of triple-negative BC, and the odds of this phenotype decreased with increasing duration of breastfeeding.

Authors+Show Affiliations

Department of Pathology, The University of Texas M. D. Anderson Cancer Center, Houston, Texas 77030, USA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

20665494

Citation

Shinde, Shivani S., et al. "Higher Parity and Shorter Breastfeeding Duration: Association With Triple-negative Phenotype of Breast Cancer." Cancer, vol. 116, no. 21, 2010, pp. 4933-43.
Shinde SS, Forman MR, Kuerer HM, et al. Higher parity and shorter breastfeeding duration: association with triple-negative phenotype of breast cancer. Cancer. 2010;116(21):4933-43.
Shinde, S. S., Forman, M. R., Kuerer, H. M., Yan, K., Peintinger, F., Hunt, K. K., Hortobagyi, G. N., Pusztai, L., & Symmans, W. F. (2010). Higher parity and shorter breastfeeding duration: association with triple-negative phenotype of breast cancer. Cancer, 116(21), 4933-43. https://doi.org/10.1002/cncr.25443
Shinde SS, et al. Higher Parity and Shorter Breastfeeding Duration: Association With Triple-negative Phenotype of Breast Cancer. Cancer. 2010 Nov 1;116(21):4933-43. PubMed PMID: 20665494.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Higher parity and shorter breastfeeding duration: association with triple-negative phenotype of breast cancer. AU - Shinde,Shivani S, AU - Forman,Michele R, AU - Kuerer,Henry M, AU - Yan,Kai, AU - Peintinger,Florentia, AU - Hunt,Kelly K, AU - Hortobagyi,Gabriel N, AU - Pusztai,Lajos, AU - Symmans,W Fraser, PY - 2010/7/29/entrez PY - 2010/7/29/pubmed PY - 2010/12/16/medline SP - 4933 EP - 43 JF - Cancer JO - Cancer VL - 116 IS - 21 N2 - BACKGROUND: The combination of increased parity and shorter breastfeeding duration might increase the odds of the least differentiated triple-negative breast cancer (BC) phenotype, theoretically because an expanded progenitor cell population from each pregnancy would incompletely differentiate postpartum. METHODS: Subjects consisted of a consecutive case series of 2473 women treated for invasive breast cancer between 2001 and 2006. Breast cancer phenotype (triple-negative BC, vs non-triple-negative BC) was compared with reproductive and demographic information. Odds ratios (OR) with 95% confidence intervals (CIs) for the association of breastfeeding duration (months per child) and parity with triple-negative BC were calculated after adjusting for ethnicity, age at menarche, family history, and age at diagnosis. RESULTS: Compared with non-triple-negative BC, triple-negative BC was associated with shorter duration of breastfeeding per child (OR, 0.93; 95% CI, 0.90-0.97) and with higher parity (OR, 1.12; 95% CI, 1.06-1.20). By using multivariate logistic regression, triple-negative BC was independently associated with higher parity (OR, 2.76 [95% CI, 1.86-4.08] if ≥3 live births; OR, 1.89 [95% CI, 1.30-2.74] if ≤2 live births vs nulliparae), breastfeeding duration (OR, 0.55 [95% CI, 0.41-0.74] if >2 mo/child and OR, 0.58 [95% CI, 0.42-0.82] if ≤2 mo/child vs none), African American ethnicity (OR, 2.10; 95% CI, 1.52-2.92), and younger age at diagnosis (OR, 3.02 [95% CI, 2.03-4.47] if ≤40 years vs >60 years). CONCLUSIONS: Among women with invasive breast cancer, higher parity and the absence or short duration of breastfeeding were independently associated with triple-negative BC. Any duration of breastfeeding was found to be associated with lower probability of triple-negative BC, and the odds of this phenotype decreased with increasing duration of breastfeeding. SN - 0008-543X UR - https://www.unboundmedicine.com/medline/citation/20665494/Higher_parity_and_shorter_breastfeeding_duration:_association_with_triple_negative_phenotype_of_breast_cancer_ L2 - https://doi.org/10.1002/cncr.25443 DB - PRIME DP - Unbound Medicine ER -