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Efficacy of CO(2) laser for treatment of anthroponotic cutaneous leishmaniasis, compared with combination of cryotherapy and intralesional meglumine antimoniate.
J Eur Acad Dermatol Venereol. 2011 May; 25(5):587-91.JE

Abstract

BACKGROUND

Cutaneous leishmaniasis (CL) is endemic in developing countries. Several types of treatments have been suggested, but none of them is completely effective and without side-effects. CO(2) laser has a specific thermolysis effect on infected tissues in CL.

OBJECTIVES

To determine the efficacy and safety of CO(2) laser vs. combined cryotherapy and intralesional meglumine antimoniate (glucantime) in dry-type CL.

METHODS

This is a prospective, randomized open trial study (Kerman, Iran) from November 2007 to August 2009. A total of 96 patients were randomly assigned to receive one session of CO(2) laser therapy and 95 patients on combined cryotherapy biweekly with intralesional meglumine antimoniate weekly until complete cure or up to 12 weeks, whichever is earlier. Clinical and laboratory cure, defined as complete re-epithelialization of 100%, complete flattening of induration and negative smear of lesions compared with baseline at weeks 2, 6, 12 and 16, and also at the time of complete cure (week 2, 6, 12 or 16).

RESULTS

Of 191 participants, 80 patients with 95 lesions in group A and 80 patients with 95 lesions in group B completed the study. Complete cure was 93.7% (89/95 lesions) in group A and 78% (74/95 lesions) in group B. Complications were similar in the two groups and were limited to the ulcer sites.

CONCLUSIONS

The CO(2) laser was more effective in treating dry-type cutaneous leishmaniasis than combined cryotherapy and intralesional glucantime and resulted in a shorter healing time (6 weeks vs. 12 weeks) with a single treatment session.

Authors+Show Affiliations

Kerman Leishmania Research Center, Dermatology Department, Afzalipour Hospital, Kerman, Iran. meymandi_s@hotmail.comNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Randomized Controlled Trial

Language

eng

PubMed ID

20666876

Citation

Shamsi Meymandi, S, et al. "Efficacy of CO(2) Laser for Treatment of Anthroponotic Cutaneous Leishmaniasis, Compared With Combination of Cryotherapy and Intralesional Meglumine Antimoniate." Journal of the European Academy of Dermatology and Venereology : JEADV, vol. 25, no. 5, 2011, pp. 587-91.
Shamsi Meymandi S, Zandi S, Aghaie H, et al. Efficacy of CO(2) laser for treatment of anthroponotic cutaneous leishmaniasis, compared with combination of cryotherapy and intralesional meglumine antimoniate. J Eur Acad Dermatol Venereol. 2011;25(5):587-91.
Shamsi Meymandi, S., Zandi, S., Aghaie, H., & Heshmatkhah, A. (2011). Efficacy of CO(2) laser for treatment of anthroponotic cutaneous leishmaniasis, compared with combination of cryotherapy and intralesional meglumine antimoniate. Journal of the European Academy of Dermatology and Venereology : JEADV, 25(5), 587-91. https://doi.org/10.1111/j.1468-3083.2010.03781.x
Shamsi Meymandi S, et al. Efficacy of CO(2) Laser for Treatment of Anthroponotic Cutaneous Leishmaniasis, Compared With Combination of Cryotherapy and Intralesional Meglumine Antimoniate. J Eur Acad Dermatol Venereol. 2011;25(5):587-91. PubMed PMID: 20666876.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Efficacy of CO(2) laser for treatment of anthroponotic cutaneous leishmaniasis, compared with combination of cryotherapy and intralesional meglumine antimoniate. AU - Shamsi Meymandi,S, AU - Zandi,S, AU - Aghaie,H, AU - Heshmatkhah,A, PY - 2010/7/30/entrez PY - 2010/7/30/pubmed PY - 2011/8/13/medline SP - 587 EP - 91 JF - Journal of the European Academy of Dermatology and Venereology : JEADV JO - J Eur Acad Dermatol Venereol VL - 25 IS - 5 N2 - BACKGROUND: Cutaneous leishmaniasis (CL) is endemic in developing countries. Several types of treatments have been suggested, but none of them is completely effective and without side-effects. CO(2) laser has a specific thermolysis effect on infected tissues in CL. OBJECTIVES: To determine the efficacy and safety of CO(2) laser vs. combined cryotherapy and intralesional meglumine antimoniate (glucantime) in dry-type CL. METHODS: This is a prospective, randomized open trial study (Kerman, Iran) from November 2007 to August 2009. A total of 96 patients were randomly assigned to receive one session of CO(2) laser therapy and 95 patients on combined cryotherapy biweekly with intralesional meglumine antimoniate weekly until complete cure or up to 12 weeks, whichever is earlier. Clinical and laboratory cure, defined as complete re-epithelialization of 100%, complete flattening of induration and negative smear of lesions compared with baseline at weeks 2, 6, 12 and 16, and also at the time of complete cure (week 2, 6, 12 or 16). RESULTS: Of 191 participants, 80 patients with 95 lesions in group A and 80 patients with 95 lesions in group B completed the study. Complete cure was 93.7% (89/95 lesions) in group A and 78% (74/95 lesions) in group B. Complications were similar in the two groups and were limited to the ulcer sites. CONCLUSIONS: The CO(2) laser was more effective in treating dry-type cutaneous leishmaniasis than combined cryotherapy and intralesional glucantime and resulted in a shorter healing time (6 weeks vs. 12 weeks) with a single treatment session. SN - 1468-3083 UR - https://www.unboundmedicine.com/medline/citation/20666876/Efficacy_of_CO_2__laser_for_treatment_of_anthroponotic_cutaneous_leishmaniasis_compared_with_combination_of_cryotherapy_and_intralesional_meglumine_antimoniate_ L2 - https://doi.org/10.1111/j.1468-3083.2010.03781.x DB - PRIME DP - Unbound Medicine ER -