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Scrub typhus associated macrophage activation syndrome.
Trop Doct 2010; 40(4):249-50TD

Abstract

Macrophage activation syndrome (MAS) is a rare phenomenon that occurs either primarily or secondary to a multitude of conditions, including juvenile rheumatoid arthritis most commonly, and other infections like enteric fever and tuberculosis. It has been reported as an extremely rare complication of scrub typhus with no cases presented from India. We report three cases of scrub typhus presenting with confirmed MAS between January 2007 and December 2007 to a tertiary care hospital in South India. All three patients had clinical and laboratory evidence for scrub typhus and MAS. All the patients responded promptly to antibiotics and made an uneventful recovery. These three patients are presented to highlight the importance of considering scrub typhus in patients with MAS following acute febrile illnesses.

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  • Publisher Full Text

    • Authors+Show Affiliations

    Gopal GK
    Department of Medicine - 3, Christian Medical College, Vellore, India. gops95@yahoo.com
    Anugrah C
    No affiliation info available
    Boorugu H
    No affiliation info available

    MeSH

    AdultAnti-Bacterial AgentsBone MarrowDoxycyclineEnzyme-Linked Immunosorbent AssayHumansImmunoglobulin MMacrophage Activation SyndromeMaleMiddle AgedOrientia tsutsugamushiScrub TyphusTreatment Outcome

    Pub Type(s)

    Case Reports
    Journal Article

    Language

    eng

    PubMed ID

    20667920

    Citation

    Gopal, Gopinath Kango, et al. "Scrub Typhus Associated Macrophage Activation Syndrome." Tropical Doctor, vol. 40, no. 4, 2010, pp. 249-50.
    Gopal GK, Anugrah C, Boorugu H. Scrub typhus associated macrophage activation syndrome. Trop Doct. 2010;40(4):249-50.
    Gopal, G. K., Anugrah, C., & Boorugu, H. (2010). Scrub typhus associated macrophage activation syndrome. Tropical Doctor, 40(4), pp. 249-50. doi:10.1258/td.2010.100056.
    Gopal GK, Anugrah C, Boorugu H. Scrub Typhus Associated Macrophage Activation Syndrome. Trop Doct. 2010;40(4):249-50. PubMed PMID: 20667920.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Scrub typhus associated macrophage activation syndrome. AU - Gopal,Gopinath Kango, AU - Anugrah,Chrispal, AU - Boorugu,Harikishan, Y1 - 2010/07/28/ PY - 2010/7/30/entrez PY - 2010/7/30/pubmed PY - 2010/11/3/medline SP - 249 EP - 50 JF - Tropical doctor JO - Trop Doct VL - 40 IS - 4 N2 - Macrophage activation syndrome (MAS) is a rare phenomenon that occurs either primarily or secondary to a multitude of conditions, including juvenile rheumatoid arthritis most commonly, and other infections like enteric fever and tuberculosis. It has been reported as an extremely rare complication of scrub typhus with no cases presented from India. We report three cases of scrub typhus presenting with confirmed MAS between January 2007 and December 2007 to a tertiary care hospital in South India. All three patients had clinical and laboratory evidence for scrub typhus and MAS. All the patients responded promptly to antibiotics and made an uneventful recovery. These three patients are presented to highlight the importance of considering scrub typhus in patients with MAS following acute febrile illnesses. SN - 1758-1133 UR - https://www.unboundmedicine.com/medline/citation/20667920/Scrub_typhus_associated_macrophage_activation_syndrome_ L2 - http://journals.sagepub.com/doi/full/10.1258/td.2010.100056?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -