Tags

Type your tag names separated by a space and hit enter

Association between admission hypoglycaemia and in-hospital and 3-year mortality in older patients with acute myocardial infarction.
Heart. 2010 Sep; 96(18):1444-50.H

Abstract

OBJECTIVE

To assess the association between fasting plasma glucose (FPG) levels on admission and mortality in older patients with acute myocardial infarction (AMI), and compare the effects of FPG levels on outcomes in the context of contemporary treatments, including drug treatment, percutaneous coronary intervention and coronary artery bypass grafting.

METHODS

From April 2004 to October 2006, 1854 older (age > or =65 years) patients with AMI were enrolled in the Beijing Elderly Acute Myocardial Infarction Study (BEAMIS) consecutively. Patients were categorised into 4 groups: hypoglycaemia group (N=443, 23.9%), FPG< or =5 mmol/l; euglycaemia group (N=812, 43.8%), FPG> or = 5.1 to< or =7.0 mmol/l (5-7 mmol/l); mild hyperglycaemia group (N=308, 16.6%), FPG> or = 7.1 to< or =9.0 mmol/l (7-9 mmol/l); and severe hyperglycaemia group (N=291, 15.7%), FPG> or =9.1 mmol/l. The primary end point was in-hospital and 3-year all-cause mortality from the day of admission.

RESULTS

Compared with the euglycaemia group, hypoglycaemia or hyperglycaemia groups were all associated with higher in-hospital and 3-year all-cause mortality. There was a U-shaped relationship between admission FPG levels and short- and long-term all-cause mortality. This U-shaped relationship applied equally to subgroups in the context of contemporary treatments.

CONCLUSIONS

In older patients with AMI, increased as well as decreased admission FPG levels could predict higher in-hospital and 3-year mortality. There was a striking U-shaped relationship between admission FPG levels and short- and long-term mortality. An initial admission FPG level > or = 5.1 to< or =7.0 mmol/l may be desirable because it was associated with better clinical outcomes.

Authors+Show Affiliations

12th Ward, Department of Cardiology, Beijing Anzhen Hospital Affiliated to Capital Medical University, Beijing, China.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Multicenter Study
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

20668105

Citation

Yang, Shi-Wei, et al. "Association Between Admission Hypoglycaemia and In-hospital and 3-year Mortality in Older Patients With Acute Myocardial Infarction." Heart (British Cardiac Society), vol. 96, no. 18, 2010, pp. 1444-50.
Yang SW, Zhou YJ, Hu DY, et al. Association between admission hypoglycaemia and in-hospital and 3-year mortality in older patients with acute myocardial infarction. Heart. 2010;96(18):1444-50.
Yang, S. W., Zhou, Y. J., Hu, D. Y., Nie, X. M., Liu, Y. Y., Hua, Q., Wang, X., & Li, H. W. (2010). Association between admission hypoglycaemia and in-hospital and 3-year mortality in older patients with acute myocardial infarction. Heart (British Cardiac Society), 96(18), 1444-50. https://doi.org/10.1136/hrt.2009.189316
Yang SW, et al. Association Between Admission Hypoglycaemia and In-hospital and 3-year Mortality in Older Patients With Acute Myocardial Infarction. Heart. 2010;96(18):1444-50. PubMed PMID: 20668105.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Association between admission hypoglycaemia and in-hospital and 3-year mortality in older patients with acute myocardial infarction. AU - Yang,Shi-Wei, AU - Zhou,Yu-Jie, AU - Hu,Da-Yi, AU - Nie,Xiao-Min, AU - Liu,Yu-Yang, AU - Hua,Qi, AU - Wang,Xian, AU - Li,Hong-Wei, AU - ,, Y1 - 2010/07/28/ PY - 2010/7/30/entrez PY - 2010/7/30/pubmed PY - 2010/10/29/medline SP - 1444 EP - 50 JF - Heart (British Cardiac Society) JO - Heart VL - 96 IS - 18 N2 - OBJECTIVE: To assess the association between fasting plasma glucose (FPG) levels on admission and mortality in older patients with acute myocardial infarction (AMI), and compare the effects of FPG levels on outcomes in the context of contemporary treatments, including drug treatment, percutaneous coronary intervention and coronary artery bypass grafting. METHODS: From April 2004 to October 2006, 1854 older (age > or =65 years) patients with AMI were enrolled in the Beijing Elderly Acute Myocardial Infarction Study (BEAMIS) consecutively. Patients were categorised into 4 groups: hypoglycaemia group (N=443, 23.9%), FPG< or =5 mmol/l; euglycaemia group (N=812, 43.8%), FPG> or = 5.1 to< or =7.0 mmol/l (5-7 mmol/l); mild hyperglycaemia group (N=308, 16.6%), FPG> or = 7.1 to< or =9.0 mmol/l (7-9 mmol/l); and severe hyperglycaemia group (N=291, 15.7%), FPG> or =9.1 mmol/l. The primary end point was in-hospital and 3-year all-cause mortality from the day of admission. RESULTS: Compared with the euglycaemia group, hypoglycaemia or hyperglycaemia groups were all associated with higher in-hospital and 3-year all-cause mortality. There was a U-shaped relationship between admission FPG levels and short- and long-term all-cause mortality. This U-shaped relationship applied equally to subgroups in the context of contemporary treatments. CONCLUSIONS: In older patients with AMI, increased as well as decreased admission FPG levels could predict higher in-hospital and 3-year mortality. There was a striking U-shaped relationship between admission FPG levels and short- and long-term mortality. An initial admission FPG level > or = 5.1 to< or =7.0 mmol/l may be desirable because it was associated with better clinical outcomes. SN - 1468-201X UR - https://www.unboundmedicine.com/medline/citation/20668105/Association_between_admission_hypoglycaemia_and_in_hospital_and_3_year_mortality_in_older_patients_with_acute_myocardial_infarction_ L2 - http://heart.bmj.com/cgi/pmidlookup?view=long&amp;pmid=20668105 DB - PRIME DP - Unbound Medicine ER -