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[A role for the endocannabinoid system in obesity].
Rev Med Chil. 2010 May; 138(5):621-9.RM

Abstract

Endocannabinoids are the endogenous ligands for the cannabinoid receptors type 1 and 2. These membrane receptors are responsible for the psychotropic effects of Cannabis Sativa, when bound to its active component known as (-)-Delta(9)-tetrahydro-cannabinol. Cannabinoid receptors, endocannabinoids and the enzymes catalyzing their biosynthesis and degradation, constitute the endocannabinoid system (ECS), which has a remarkable role controlling energy balance, both at central nervous system and peripheral tissues. The ECS regulates food ingestion by stimulating a network of orexigenic neurons present in the hypothalamus and reinforcing motivation and reward to food consumption in the nucleus accumbens. Regarding peripheral tissues, this system controls lipid and glucose metabolism at different levels, reduces energy expenditure and leads energy balance to fat storage. Metabolic alterations, including excessive accumulation of abdominal fat, dyslipidaemia and hyperglicaemia, are suggested to be associated to a hyperactivated ECS. Since obesity is one of the major health problems in modern societies, in this review we discuss the role of the endocannabinoid system in metabolic pathways associated to control mechanisms of energy balance and its involvement in overweight and obesity. In addition, we also discuss therapeutic possibilities and emergent problems due to cannabinoid receptor type 1 antagonism utilized as treatment for such alterations.

Authors+Show Affiliations

Laboratorio de Nutrición y Regulación Metabólica, Instituto de Nutrición y Tecnología de los Alimentos, Universidad de Chile, Santiago, Chile.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

English Abstract
Journal Article
Research Support, Non-U.S. Gov't
Review

Language

spa

PubMed ID

20668819

Citation

Valenzuela, Carina, et al. "[A Role for the Endocannabinoid System in Obesity]." Revista Medica De Chile, vol. 138, no. 5, 2010, pp. 621-9.
Valenzuela C, Aguirre C, Castillo V, et al. [A role for the endocannabinoid system in obesity]. Rev Med Chil. 2010;138(5):621-9.
Valenzuela, C., Aguirre, C., Castillo, V., Ronco, A. M., & Llanos, M. (2010). [A role for the endocannabinoid system in obesity]. Revista Medica De Chile, 138(5), 621-9. https://doi.org//S0034-98872010000500014
Valenzuela C, et al. [A Role for the Endocannabinoid System in Obesity]. Rev Med Chil. 2010;138(5):621-9. PubMed PMID: 20668819.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [A role for the endocannabinoid system in obesity]. AU - Valenzuela,Carina, AU - Aguirre,Carolina, AU - Castillo,Valeska, AU - Ronco,Ana María, AU - Llanos,Miguel, Y1 - 2010/07/12/ PY - 2010/7/30/entrez PY - 2010/7/30/pubmed PY - 2011/5/6/medline SP - 621 EP - 9 JF - Revista medica de Chile JO - Rev Med Chil VL - 138 IS - 5 N2 - Endocannabinoids are the endogenous ligands for the cannabinoid receptors type 1 and 2. These membrane receptors are responsible for the psychotropic effects of Cannabis Sativa, when bound to its active component known as (-)-Delta(9)-tetrahydro-cannabinol. Cannabinoid receptors, endocannabinoids and the enzymes catalyzing their biosynthesis and degradation, constitute the endocannabinoid system (ECS), which has a remarkable role controlling energy balance, both at central nervous system and peripheral tissues. The ECS regulates food ingestion by stimulating a network of orexigenic neurons present in the hypothalamus and reinforcing motivation and reward to food consumption in the nucleus accumbens. Regarding peripheral tissues, this system controls lipid and glucose metabolism at different levels, reduces energy expenditure and leads energy balance to fat storage. Metabolic alterations, including excessive accumulation of abdominal fat, dyslipidaemia and hyperglicaemia, are suggested to be associated to a hyperactivated ECS. Since obesity is one of the major health problems in modern societies, in this review we discuss the role of the endocannabinoid system in metabolic pathways associated to control mechanisms of energy balance and its involvement in overweight and obesity. In addition, we also discuss therapeutic possibilities and emergent problems due to cannabinoid receptor type 1 antagonism utilized as treatment for such alterations. SN - 0034-9887 UR - https://www.unboundmedicine.com/medline/citation/20668819/[A_role_for_the_endocannabinoid_system_in_obesity]_ L2 - http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872010000500014&lng=en&nrm=iso&tlng=en DB - PRIME DP - Unbound Medicine ER -