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The role of ultrasonography and FDG-PET in axillary lymph node staging of breast cancer.
Acta Radiol. 2010 Oct; 51(8):859-65.AR

Abstract

BACKGROUND

The presence of axillary lymph node metastasis is the most important prognostic factor and an essential part of staging and prognosis of breast cancer.

PURPOSE

To elucidate the usefulness and accuracy of ultrasonography (US), fluorodeoxyglucose positron emission tomography (FDG-PET) scan, and combined analysis for axillary lymph node staging in breast cancer.

MATERIAL AND METHODS

A total of 250 consecutive breast cancer patients who had undergone US, FDG-PET, and sentinel lymph node biopsy (SLNB) before surgery from January 2005 to December 2006 were included in the study. If an axillary lymph node had a length to width ratio <or=1.5 or cortical thickening >or=3 mm or compression of the hilum on US, focal hot uptake (maximal standardized uptake value, SUVmax >or=2.0) in the ipsilateral axilla on FDG-PET, it was considered to be a metastatic lymph node. In combined analysis of US and FDG-PET, the interpretation was considered positive if at least two of any of the criteria were met. Each imaging finding was compared with a pathologic report regarding the presence of axillary lymph node metastasis, the number of metastatic lymph nodes, and the T stage of the breast mass.

RESULTS

Pathologically confirmed axillary lymph node metastasis was noted in 73 cases (29.2%). The mean number of metastatic lymph nodes in pathology was 3.1 +/- 3.2, and the size of breast cancer was 2.0 +/- 1.04 cm. In the detection of lymph node metastasis, the diagnostic accuracy of US was 78.8% and that of FDG-PET was 76.4%. On combined US and FDG-PET, accuracy was improved (91.6%). The number of metastatic lymph nodes on pathology was correlated with the positivity of US and FDG-PET (P < 0.01).

CONCLUSION

Combined evaluation of US and FDG-PET was a sensitive and accurate method for axillary lymph node staging in breast cancer.

Authors+Show Affiliations

Department of Radiology, Yonsei University College of Medicine, Research Institute of Radiological Science, Gangnam-gu, Seoul, Korea.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Evaluation Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

20670083

Citation

Ahn, Jhii-Hyun, et al. "The Role of Ultrasonography and FDG-PET in Axillary Lymph Node Staging of Breast Cancer." Acta Radiologica (Stockholm, Sweden : 1987), vol. 51, no. 8, 2010, pp. 859-65.
Ahn JH, Son EJ, Kim JA, et al. The role of ultrasonography and FDG-PET in axillary lymph node staging of breast cancer. Acta Radiol. 2010;51(8):859-65.
Ahn, J. H., Son, E. J., Kim, J. A., Youk, J. H., Kim, E. K., Kwak, J. Y., Ryu, Y. H., & Jeong, J. (2010). The role of ultrasonography and FDG-PET in axillary lymph node staging of breast cancer. Acta Radiologica (Stockholm, Sweden : 1987), 51(8), 859-65. https://doi.org/10.3109/02841851.2010.501342
Ahn JH, et al. The Role of Ultrasonography and FDG-PET in Axillary Lymph Node Staging of Breast Cancer. Acta Radiol. 2010;51(8):859-65. PubMed PMID: 20670083.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The role of ultrasonography and FDG-PET in axillary lymph node staging of breast cancer. AU - Ahn,Jhii-Hyun, AU - Son,Eun Ju, AU - Kim,Jeong-Ah, AU - Youk,Ji Hyun, AU - Kim,Eun-Kyung, AU - Kwak,Jin Young, AU - Ryu,Young Hoon, AU - Jeong,Joon, PY - 2010/7/31/entrez PY - 2010/7/31/pubmed PY - 2010/9/25/medline SP - 859 EP - 65 JF - Acta radiologica (Stockholm, Sweden : 1987) JO - Acta Radiol VL - 51 IS - 8 N2 - BACKGROUND: The presence of axillary lymph node metastasis is the most important prognostic factor and an essential part of staging and prognosis of breast cancer. PURPOSE: To elucidate the usefulness and accuracy of ultrasonography (US), fluorodeoxyglucose positron emission tomography (FDG-PET) scan, and combined analysis for axillary lymph node staging in breast cancer. MATERIAL AND METHODS: A total of 250 consecutive breast cancer patients who had undergone US, FDG-PET, and sentinel lymph node biopsy (SLNB) before surgery from January 2005 to December 2006 were included in the study. If an axillary lymph node had a length to width ratio <or=1.5 or cortical thickening >or=3 mm or compression of the hilum on US, focal hot uptake (maximal standardized uptake value, SUVmax >or=2.0) in the ipsilateral axilla on FDG-PET, it was considered to be a metastatic lymph node. In combined analysis of US and FDG-PET, the interpretation was considered positive if at least two of any of the criteria were met. Each imaging finding was compared with a pathologic report regarding the presence of axillary lymph node metastasis, the number of metastatic lymph nodes, and the T stage of the breast mass. RESULTS: Pathologically confirmed axillary lymph node metastasis was noted in 73 cases (29.2%). The mean number of metastatic lymph nodes in pathology was 3.1 +/- 3.2, and the size of breast cancer was 2.0 +/- 1.04 cm. In the detection of lymph node metastasis, the diagnostic accuracy of US was 78.8% and that of FDG-PET was 76.4%. On combined US and FDG-PET, accuracy was improved (91.6%). The number of metastatic lymph nodes on pathology was correlated with the positivity of US and FDG-PET (P < 0.01). CONCLUSION: Combined evaluation of US and FDG-PET was a sensitive and accurate method for axillary lymph node staging in breast cancer. SN - 1600-0455 UR - https://www.unboundmedicine.com/medline/citation/20670083/The_role_of_ultrasonography_and_FDG_PET_in_axillary_lymph_node_staging_of_breast_cancer_ L2 - https://journals.sagepub.com/doi/10.3109/02841851.2010.501342?url_ver=Z39.88-2003&amp;rfr_id=ori:rid:crossref.org&amp;rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -