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Polymorphism of MTHFR C677T, serum vitamin levels and cognition in subjects with hyperhomocysteinemia in China.
Nutr Neurosci. 2010 Aug; 13(4):175-82.NN

Abstract

Relationships between hyperhomocysteinemia (HHE) and neurodegenerative diseases have been widely studied. However, the impact of serum total homocysteine (tHcy) levels on cognitive function has not been confirmed. C677T polymorphisms in the 5,10-methylenetetrahydrofolate reductase (MTHFR) gene have impacts on tHcy level; it is suspected to influence cognitive function, but only few investigations have assessed its effects on non-dementia adults and the results have been controversial. Moreover, there is no report about Chinese subjects. In the present study, we determined C677T/MTHFR genotype, serum tHcy concentration and cognition in 182 nondemented subjects aged 55-88 years to probe the associations between MTHFRC677T mutation, increased tHcy levels and decreased cognitive function in a northern city in China. A serum tHcy level > or = 16 micromol/l was deemed HHE. Cognitive function was assessed by the Mini Mental State Examination (MMSE) and Basic Cognitive Aptitude Tests (BCAT). Results showed that: (i) subjects with the T allele had higher serum tHcy levels than those without, especially in lower folate status; (ii) T allele and CT/TT genotype frequencies in subjects with HHE were higher than in non-HHE subjects (P < 0.05); and (iii) serum tHcy level was inversely related to total BCAT score (P < 0.05) but MTHFR677 C to T polymorphism had no association with it. Our results confirmed that the MTHFR 677 C to T mutation, especially in lower serum folate concentration status, results in the increase of serum tHcy levels which is bad for cognitive function and indicates that higher serum folate level is of benefit in keeping lower serum tHcy level and better cognitive function. The results provide some valuable clues for individualized nutrition intervention of HHE and cognition decline in the middle-aged and the elderly.

Authors+Show Affiliations

Department of Nutrition and Food Safety, West China School of Public Health, Sichuan University, Chengdu, China.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

20670473

Citation

Cheng, Dao-Mei, et al. "Polymorphism of MTHFR C677T, Serum Vitamin Levels and Cognition in Subjects With Hyperhomocysteinemia in China." Nutritional Neuroscience, vol. 13, no. 4, 2010, pp. 175-82.
Cheng DM, Jiang YG, Huang CY, et al. Polymorphism of MTHFR C677T, serum vitamin levels and cognition in subjects with hyperhomocysteinemia in China. Nutr Neurosci. 2010;13(4):175-82.
Cheng, D. M., Jiang, Y. G., Huang, C. Y., Kong, H. Y., Pang, W., & Yang, H. P. (2010). Polymorphism of MTHFR C677T, serum vitamin levels and cognition in subjects with hyperhomocysteinemia in China. Nutritional Neuroscience, 13(4), 175-82. https://doi.org/10.1179/147683010X12611460764200
Cheng DM, et al. Polymorphism of MTHFR C677T, Serum Vitamin Levels and Cognition in Subjects With Hyperhomocysteinemia in China. Nutr Neurosci. 2010;13(4):175-82. PubMed PMID: 20670473.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Polymorphism of MTHFR C677T, serum vitamin levels and cognition in subjects with hyperhomocysteinemia in China. AU - Cheng,Dao-Mei, AU - Jiang,Yu-Gang, AU - Huang,Cheng-Yu, AU - Kong,Hai-Yan, AU - Pang,Wei, AU - Yang,Hong-Peng, PY - 2010/7/31/entrez PY - 2010/7/31/pubmed PY - 2010/10/26/medline SP - 175 EP - 82 JF - Nutritional neuroscience JO - Nutr Neurosci VL - 13 IS - 4 N2 - Relationships between hyperhomocysteinemia (HHE) and neurodegenerative diseases have been widely studied. However, the impact of serum total homocysteine (tHcy) levels on cognitive function has not been confirmed. C677T polymorphisms in the 5,10-methylenetetrahydrofolate reductase (MTHFR) gene have impacts on tHcy level; it is suspected to influence cognitive function, but only few investigations have assessed its effects on non-dementia adults and the results have been controversial. Moreover, there is no report about Chinese subjects. In the present study, we determined C677T/MTHFR genotype, serum tHcy concentration and cognition in 182 nondemented subjects aged 55-88 years to probe the associations between MTHFRC677T mutation, increased tHcy levels and decreased cognitive function in a northern city in China. A serum tHcy level > or = 16 micromol/l was deemed HHE. Cognitive function was assessed by the Mini Mental State Examination (MMSE) and Basic Cognitive Aptitude Tests (BCAT). Results showed that: (i) subjects with the T allele had higher serum tHcy levels than those without, especially in lower folate status; (ii) T allele and CT/TT genotype frequencies in subjects with HHE were higher than in non-HHE subjects (P < 0.05); and (iii) serum tHcy level was inversely related to total BCAT score (P < 0.05) but MTHFR677 C to T polymorphism had no association with it. Our results confirmed that the MTHFR 677 C to T mutation, especially in lower serum folate concentration status, results in the increase of serum tHcy levels which is bad for cognitive function and indicates that higher serum folate level is of benefit in keeping lower serum tHcy level and better cognitive function. The results provide some valuable clues for individualized nutrition intervention of HHE and cognition decline in the middle-aged and the elderly. SN - 1476-8305 UR - https://www.unboundmedicine.com/medline/citation/20670473/Polymorphism_of_MTHFR_C677T_serum_vitamin_levels_and_cognition_in_subjects_with_hyperhomocysteinemia_in_China_ L2 - https://www.tandfonline.com/doi/full/10.1179/147683010X12611460764200 DB - PRIME DP - Unbound Medicine ER -