Type your tag names separated by a space and hit enter
Maternal ethnicity influences on neonatal respiratory outcomes after antenatal corticosteroid use for anticipated preterm delivery.
OBJECTIVETo explore the influence of maternal ethnicity on neonatal outcomes after antenatal corticosteroid administration.
METHODSA retrospective review of ethnicity, maternal factors, and neonatal birth outcomes was performed for preterm births at a single institution. Cases were limited to women who received antenatal corticosteroids. The impact of ethnicity on specific neonatal respiratory outcomes and mortality was analyzed by bivariate comparisons and by logistic regression analysis.
RESULTSComplete ethnicity data were obtained for 548 women. Controlling for gestational age at delivery, diabetes, whether the subject completed a course of steroids, and the dosing of the steroids, logistic regression demonstrated that ethnicity was independently associated with respiratory distress syndrome (compared to Caucasians: African-Americans OR 0.49 (95% CI 0.29-0.85); Filipinos OR 0.45 (95% CI 0.21-0.96).
CONCLUSIONSEthnicity is independently associated with neonatal respiratory outcomes after antenatal corticosteroid use. Perhaps individualized dosing of antenatal corticosteroids is needed to further improve neonatal outcomes.
Department of OB/GYN, Indiana University School of Medicine, Indianapolis, IN, USA. firstname.lastname@example.org, ,
MeSHAdrenal Cortex Hormones
Respiratory Distress Syndrome, Newborn
Pub Type(s)Evaluation Studies
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.