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Approaches to transfusion therapy and iron overload in patients with sickle cell disease: results of an international survey.
Pediatr Hematol Oncol. 2011 Feb; 28(1):37-42.PH

Abstract

To gain an insight into current transfusion and chelation practice in patients with sickle cell disease (SCD), a survey of international experts has been conducted. The findings demonstrate that general utilization of transfusion therapy is low, the primary barrier to treatment being concerns over resultant iron overload and the subsequent need for iron chelation therapy. Where patients were transfused, many physicians indicated that a high proportion of patients had hemosiderosis. As evidence suggests more patients with SCD could benefit from regular transfusion therapy, it is apparent that greater awareness of the need to monitor and treat iron overload in transfused patients is required.

Authors+Show Affiliations

Hematology/Oncology Department, Children's Hospital & Research Center Oakland, CA 94609, USA. EVichinsky@mail.cho.orgNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

20673029

Citation

Vichinsky, Elliott P., et al. "Approaches to Transfusion Therapy and Iron Overload in Patients With Sickle Cell Disease: Results of an International Survey." Pediatric Hematology and Oncology, vol. 28, no. 1, 2011, pp. 37-42.
Vichinsky EP, Ohene-Frempong K, Transfusion Committee. Approaches to transfusion therapy and iron overload in patients with sickle cell disease: results of an international survey. Pediatr Hematol Oncol. 2011;28(1):37-42.
Vichinsky, E. P., & Ohene-Frempong, K. (2011). Approaches to transfusion therapy and iron overload in patients with sickle cell disease: results of an international survey. Pediatric Hematology and Oncology, 28(1), 37-42. https://doi.org/10.3109/08880018.2010.505497
Vichinsky EP, Ohene-Frempong K, Transfusion Committee. Approaches to Transfusion Therapy and Iron Overload in Patients With Sickle Cell Disease: Results of an International Survey. Pediatr Hematol Oncol. 2011;28(1):37-42. PubMed PMID: 20673029.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Approaches to transfusion therapy and iron overload in patients with sickle cell disease: results of an international survey. AU - Vichinsky,Elliott P, AU - Ohene-Frempong,Kwaku, AU - ,, Y1 - 2010/07/30/ PY - 2010/8/3/entrez PY - 2010/8/3/pubmed PY - 2012/2/11/medline SP - 37 EP - 42 JF - Pediatric hematology and oncology JO - Pediatr Hematol Oncol VL - 28 IS - 1 N2 - To gain an insight into current transfusion and chelation practice in patients with sickle cell disease (SCD), a survey of international experts has been conducted. The findings demonstrate that general utilization of transfusion therapy is low, the primary barrier to treatment being concerns over resultant iron overload and the subsequent need for iron chelation therapy. Where patients were transfused, many physicians indicated that a high proportion of patients had hemosiderosis. As evidence suggests more patients with SCD could benefit from regular transfusion therapy, it is apparent that greater awareness of the need to monitor and treat iron overload in transfused patients is required. SN - 1521-0669 UR - https://www.unboundmedicine.com/medline/citation/20673029/Approaches_to_transfusion_therapy_and_iron_overload_in_patients_with_sickle_cell_disease:_results_of_an_international_survey_ L2 - https://www.tandfonline.com/doi/full/10.3109/08880018.2010.505497 DB - PRIME DP - Unbound Medicine ER -