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Anti-inflammatory and antioxidant activities of Jungia paniculata.
Pharm Biol. 2010 Aug; 48(8):897-905.PB

Abstract

The present study was conducted to evaluate the antioxidant and anti-inflammatory activities of Jungia paniculata (DC.) A. Gray (Asteraceae), used traditionally in Peru. The dry leaves were extracted with methanol, 50% methanol, and water. The anti-inflammatory activity of this plant was studied using in vitro (nitric oxide production in RAW 264.7 macrophages and sPLA(2) inhibition assay) and in vivo (carrageenan-induced paw edema in rats and TPA-induced ear edema in mice) model systems. The antioxidant activity of extracts was studied using three in vitro model systems (DPPH(*) radical-scavenging assay, ABTS(*+) assay, and superoxide radical-scavenging activity). The results have been correlated with total phenolics and total flavonoids contents. In the NO test of the extracts of Jungia paniculata, no significant cytotoxicities were observed at the concentrations determined by MTT assay. Only the MeOH50 extract of Jungia paniculata significantly inhibited PLA(2) enzyme activity (82.3 +/- 2.6%). At 3 h, the 50% methanol extract of Jungia paniculata at an oral dose of 500 mg/kg showed significant suppression of carrageenan-induced rat paw edema (36.36%). The same extract induced a 93.99% reduction in TPA-induced edema in topical administration. The extracts exhibited a high antioxidant activity and contained high total levels of polyphenols and flavonoids. There was a significant linear correlation between total phenolics and flavonoids contents and antioxidant activity in the three models used. In conclusion, Jungia paniculata possesses anti-inflammatory and antioxidant properties, which confirm the use of this plant in folk medicine as a topical anti-inflammatory herbal.

Authors+Show Affiliations

Departamento Farmacia y Tecnología Farmacéutica (Farmacognosia), Facultad de Farmacia, University of Navarra, Spain.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

20673177

Citation

Casado, Raquel, et al. "Anti-inflammatory and Antioxidant Activities of Jungia Paniculata." Pharmaceutical Biology, vol. 48, no. 8, 2010, pp. 897-905.
Casado R, Landa A, Calvo JJ, et al. Anti-inflammatory and antioxidant activities of Jungia paniculata. Pharm Biol. 2010;48(8):897-905.
Casado, R., Landa, A., Calvo, J. J., Del Carmen Terencio, M., & Calvo, M. I. (2010). Anti-inflammatory and antioxidant activities of Jungia paniculata. Pharmaceutical Biology, 48(8), 897-905. https://doi.org/10.3109/13880200903311128
Casado R, et al. Anti-inflammatory and Antioxidant Activities of Jungia Paniculata. Pharm Biol. 2010;48(8):897-905. PubMed PMID: 20673177.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Anti-inflammatory and antioxidant activities of Jungia paniculata. AU - Casado,Raquel, AU - Landa,Amaya, AU - Calvo,José Javier, AU - Del Carmen Terencio,María, AU - Calvo,María Isabel, PY - 2010/8/3/entrez PY - 2010/8/3/pubmed PY - 2011/5/18/medline SP - 897 EP - 905 JF - Pharmaceutical biology JO - Pharm Biol VL - 48 IS - 8 N2 - The present study was conducted to evaluate the antioxidant and anti-inflammatory activities of Jungia paniculata (DC.) A. Gray (Asteraceae), used traditionally in Peru. The dry leaves were extracted with methanol, 50% methanol, and water. The anti-inflammatory activity of this plant was studied using in vitro (nitric oxide production in RAW 264.7 macrophages and sPLA(2) inhibition assay) and in vivo (carrageenan-induced paw edema in rats and TPA-induced ear edema in mice) model systems. The antioxidant activity of extracts was studied using three in vitro model systems (DPPH(*) radical-scavenging assay, ABTS(*+) assay, and superoxide radical-scavenging activity). The results have been correlated with total phenolics and total flavonoids contents. In the NO test of the extracts of Jungia paniculata, no significant cytotoxicities were observed at the concentrations determined by MTT assay. Only the MeOH50 extract of Jungia paniculata significantly inhibited PLA(2) enzyme activity (82.3 +/- 2.6%). At 3 h, the 50% methanol extract of Jungia paniculata at an oral dose of 500 mg/kg showed significant suppression of carrageenan-induced rat paw edema (36.36%). The same extract induced a 93.99% reduction in TPA-induced edema in topical administration. The extracts exhibited a high antioxidant activity and contained high total levels of polyphenols and flavonoids. There was a significant linear correlation between total phenolics and flavonoids contents and antioxidant activity in the three models used. In conclusion, Jungia paniculata possesses anti-inflammatory and antioxidant properties, which confirm the use of this plant in folk medicine as a topical anti-inflammatory herbal. SN - 1744-5116 UR - https://www.unboundmedicine.com/medline/citation/20673177/Anti_inflammatory_and_antioxidant_activities_of_Jungia_paniculata_ DB - PRIME DP - Unbound Medicine ER -