Tags

Type your tag names separated by a space and hit enter

Epidemiology of methicillin-susceptible Staphylococcus aureus lineages in five major African towns: high prevalence of Panton-Valentine leukocidin genes.
Clin Microbiol Infect. 2011 Apr; 17(4):633-9.CM

Abstract

The epidemiology of methicillin-susceptible Staphylococcus aureus (MSSA) in Africa is poorly documented. From January 2007 to March 2008, 555 S. aureus isolates were collected from five African towns in Cameroon, Madagascar, Morocco, Niger, and Senegal; among these, 456 unique isolates were susceptible to methicillin. Approximately 50% of the MSSA isolates from each different participating centre were randomly selected for further molecular analysis. Of the 228 isolates investigated, 132 (58%) belonged to five major multilocus sequence typing (MLST) clonal complexes (CCs) (CC1, CC15, CC30, CC121 and CC152) that were not related to any successful methicillin-resistant S. aureus (MRSA) clones previously identified in the same study population. The luk-PV genes encoding Panton-Valentine leukocidin (PVL), present in 130 isolates overall (57%), were highly prevalent in isolates from Cameroon, Niger, and Senegal (West and Central Africa). This finding is of major concern, with regard to both a source of severe infections and a potential reservoir for PVL genes. This overrepresentation of PVL in MSSA could lead to the emergence and spread of successful, highly virulent PVL-positive MRSA clones, a phenomenon that has already started in Africa.

Authors+Show Affiliations

Institut Pasteur, Dakar, Senegal. sbreurec@pasteur.snNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

20673269

Citation

Breurec, S, et al. "Epidemiology of Methicillin-susceptible Staphylococcus Aureus Lineages in Five Major African Towns: High Prevalence of Panton-Valentine Leukocidin Genes." Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases, vol. 17, no. 4, 2011, pp. 633-9.
Breurec S, Fall C, Pouillot R, et al. Epidemiology of methicillin-susceptible Staphylococcus aureus lineages in five major African towns: high prevalence of Panton-Valentine leukocidin genes. Clin Microbiol Infect. 2011;17(4):633-9.
Breurec, S., Fall, C., Pouillot, R., Boisier, P., Brisse, S., Diene-Sarr, F., Djibo, S., Etienne, J., Fonkoua, M. C., Perrier-Gros-Claude, J. D., Ramarokoto, C. E., Randrianirina, F., Thiberge, J. M., Zriouil, S. B., Garin, B., & Laurent, F. (2011). Epidemiology of methicillin-susceptible Staphylococcus aureus lineages in five major African towns: high prevalence of Panton-Valentine leukocidin genes. Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases, 17(4), 633-9. https://doi.org/10.1111/j.1469-0691.2010.03320.x
Breurec S, et al. Epidemiology of Methicillin-susceptible Staphylococcus Aureus Lineages in Five Major African Towns: High Prevalence of Panton-Valentine Leukocidin Genes. Clin Microbiol Infect. 2011;17(4):633-9. PubMed PMID: 20673269.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Epidemiology of methicillin-susceptible Staphylococcus aureus lineages in five major African towns: high prevalence of Panton-Valentine leukocidin genes. AU - Breurec,S, AU - Fall,C, AU - Pouillot,R, AU - Boisier,P, AU - Brisse,S, AU - Diene-Sarr,F, AU - Djibo,S, AU - Etienne,J, AU - Fonkoua,M C, AU - Perrier-Gros-Claude,J D, AU - Ramarokoto,C E, AU - Randrianirina,F, AU - Thiberge,J M, AU - Zriouil,S B, AU - ,, AU - Garin,B, AU - Laurent,F, PY - 2010/8/3/entrez PY - 2010/8/3/pubmed PY - 2011/7/16/medline SP - 633 EP - 9 JF - Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases JO - Clin Microbiol Infect VL - 17 IS - 4 N2 - The epidemiology of methicillin-susceptible Staphylococcus aureus (MSSA) in Africa is poorly documented. From January 2007 to March 2008, 555 S. aureus isolates were collected from five African towns in Cameroon, Madagascar, Morocco, Niger, and Senegal; among these, 456 unique isolates were susceptible to methicillin. Approximately 50% of the MSSA isolates from each different participating centre were randomly selected for further molecular analysis. Of the 228 isolates investigated, 132 (58%) belonged to five major multilocus sequence typing (MLST) clonal complexes (CCs) (CC1, CC15, CC30, CC121 and CC152) that were not related to any successful methicillin-resistant S. aureus (MRSA) clones previously identified in the same study population. The luk-PV genes encoding Panton-Valentine leukocidin (PVL), present in 130 isolates overall (57%), were highly prevalent in isolates from Cameroon, Niger, and Senegal (West and Central Africa). This finding is of major concern, with regard to both a source of severe infections and a potential reservoir for PVL genes. This overrepresentation of PVL in MSSA could lead to the emergence and spread of successful, highly virulent PVL-positive MRSA clones, a phenomenon that has already started in Africa. SN - 1469-0691 UR - https://www.unboundmedicine.com/medline/citation/20673269/Epidemiology_of_methicillin_susceptible_Staphylococcus_aureus_lineages_in_five_major_African_towns:_high_prevalence_of_Panton_Valentine_leukocidin_genes_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1198-743X(14)63287-0 DB - PRIME DP - Unbound Medicine ER -