Tags

Type your tag names separated by a space and hit enter

High-resolution imaging of resolved central serous chorioretinopathy using adaptive optics scanning laser ophthalmoscopy.
Ophthalmology 2010; 117(9):1800-9, 1809.e1-2O

Abstract

OBJECTIVE

To compare pathologic changes in photoreceptors in eyes with resolved central serous chorioretinopathy (CSC) seen on high-resolution images obtained by adaptive optics scanning laser ophthalmoscopy (AO SLO) with visual acuity (VA) and findings on spectral-domain optical coherence tomography (SD OCT).

DESIGN

Observational case series.

PARTICIPANTS

Forty-five eyes of 38 patients with resolved CSC and 20 normal eyes of 20 volunteer subjects.

METHODS

All patients underwent a full ophthalmologic examination, SD OCT, and imaging with an original prototype AO SLO system fabricated using liquid crystal-on-silicon technology.

MAIN OUTCOME MEASURES

Cone mosaic patterns and cone density on AO SLO images and VA in eyes with CSC.

RESULTS

In normal eyes, AO SLO images showed a regular photoreceptor mosaic pattern and average cone densities 0.2, 0.5, and 1.0 mm from the central fovea of 67,900, 33,320, and 14,450 cones/mm(2). In eyes with CSC, cone densities were significantly lower at each distance from the central fovea (P = 0.009 at 0.2 mm, P = 0.007 at 0.5 mm, and P = 0.004 at 1.0 mm), and 2 distinct cone mosaic patterns were seen. Group 1 CSC eyes had regular cone mosaic patterns with small dark regions. Group 2 CSC eyes had irregular mosaic patterns with large dark regions. Compared with group 1, group 2 had significantly lower average cone density and worse average logarithm of the minimum angle of resolution (logMAR) VA (P<0.001). Mean cone density in eyes with disruptions in the photoreceptor inner and outer segment (IS/OS) junction or in the intermediate line on SD OCT images was significantly lower than that in eyes with an intact IS/OS junction or intermediate line (P<0.001 for both). Cone density 0.2 mm from the central fovea correlated with logMAR VA and mean foveal thickness (1-mm diameter area) measured on SD OCT images (P<0.001 for both).

CONCLUSIONS

Adaptive optics SLO images showed abnormal cone mosaic patterns and reduced cone densities in eyes with resolved CSC, and these abnormalities were associated with VA loss, suggesting that AO SLO is a useful means to detect and measure cone abnormalities associated with VA loss in these eyes.

Authors+Show Affiliations

Department of Ophthalmology and Visual Sciences, Kyoto University Graduate School of Medicine, Kyoto, Japan. ohoto@kuhp.kyotou.ac.jpNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

20673590

Citation

Ooto, Sotaro, et al. "High-resolution Imaging of Resolved Central Serous Chorioretinopathy Using Adaptive Optics Scanning Laser Ophthalmoscopy." Ophthalmology, vol. 117, no. 9, 2010, pp. 1800-9, 1809.e1-2.
Ooto S, Hangai M, Sakamoto A, et al. High-resolution imaging of resolved central serous chorioretinopathy using adaptive optics scanning laser ophthalmoscopy. Ophthalmology. 2010;117(9):1800-9, 1809.e1-2.
Ooto, S., Hangai, M., Sakamoto, A., Tsujikawa, A., Yamashiro, K., Ojima, Y., ... Yoshimura, N. (2010). High-resolution imaging of resolved central serous chorioretinopathy using adaptive optics scanning laser ophthalmoscopy. Ophthalmology, 117(9), pp. 1800-9, 1809.e1-2. doi:10.1016/j.ophtha.2010.01.042.
Ooto S, et al. High-resolution Imaging of Resolved Central Serous Chorioretinopathy Using Adaptive Optics Scanning Laser Ophthalmoscopy. Ophthalmology. 2010;117(9):1800-9, 1809.e1-2. PubMed PMID: 20673590.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - High-resolution imaging of resolved central serous chorioretinopathy using adaptive optics scanning laser ophthalmoscopy. AU - Ooto,Sotaro, AU - Hangai,Masanori, AU - Sakamoto,Atsushi, AU - Tsujikawa,Akitaka, AU - Yamashiro,Kenji, AU - Ojima,Yumiko, AU - Yamada,Yoshihiko, AU - Mukai,Hideo, AU - Oshima,Susumu, AU - Inoue,Takashi, AU - Yoshimura,Nagahisa, Y1 - 2010/07/29/ PY - 2009/08/26/received PY - 2010/01/16/revised PY - 2010/01/25/accepted PY - 2010/8/3/entrez PY - 2010/8/3/pubmed PY - 2010/9/21/medline SP - 1800-9, 1809.e1-2 JF - Ophthalmology JO - Ophthalmology VL - 117 IS - 9 N2 - OBJECTIVE: To compare pathologic changes in photoreceptors in eyes with resolved central serous chorioretinopathy (CSC) seen on high-resolution images obtained by adaptive optics scanning laser ophthalmoscopy (AO SLO) with visual acuity (VA) and findings on spectral-domain optical coherence tomography (SD OCT). DESIGN: Observational case series. PARTICIPANTS: Forty-five eyes of 38 patients with resolved CSC and 20 normal eyes of 20 volunteer subjects. METHODS: All patients underwent a full ophthalmologic examination, SD OCT, and imaging with an original prototype AO SLO system fabricated using liquid crystal-on-silicon technology. MAIN OUTCOME MEASURES: Cone mosaic patterns and cone density on AO SLO images and VA in eyes with CSC. RESULTS: In normal eyes, AO SLO images showed a regular photoreceptor mosaic pattern and average cone densities 0.2, 0.5, and 1.0 mm from the central fovea of 67,900, 33,320, and 14,450 cones/mm(2). In eyes with CSC, cone densities were significantly lower at each distance from the central fovea (P = 0.009 at 0.2 mm, P = 0.007 at 0.5 mm, and P = 0.004 at 1.0 mm), and 2 distinct cone mosaic patterns were seen. Group 1 CSC eyes had regular cone mosaic patterns with small dark regions. Group 2 CSC eyes had irregular mosaic patterns with large dark regions. Compared with group 1, group 2 had significantly lower average cone density and worse average logarithm of the minimum angle of resolution (logMAR) VA (P<0.001). Mean cone density in eyes with disruptions in the photoreceptor inner and outer segment (IS/OS) junction or in the intermediate line on SD OCT images was significantly lower than that in eyes with an intact IS/OS junction or intermediate line (P<0.001 for both). Cone density 0.2 mm from the central fovea correlated with logMAR VA and mean foveal thickness (1-mm diameter area) measured on SD OCT images (P<0.001 for both). CONCLUSIONS: Adaptive optics SLO images showed abnormal cone mosaic patterns and reduced cone densities in eyes with resolved CSC, and these abnormalities were associated with VA loss, suggesting that AO SLO is a useful means to detect and measure cone abnormalities associated with VA loss in these eyes. SN - 1549-4713 UR - https://www.unboundmedicine.com/medline/citation/20673590/High_resolution_imaging_of_resolved_central_serous_chorioretinopathy_using_adaptive_optics_scanning_laser_ophthalmoscopy_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0161-6420(10)00115-6 DB - PRIME DP - Unbound Medicine ER -