Tags

Type your tag names separated by a space and hit enter

Skin and urine pentosidine weakly correlate with joint damage in a cohort of patients with early signs of osteoarthritis (CHECK).
Osteoarthritis Cartilage 2010; 18(10):1329-36OC

Abstract

OBJECTIVES

Age-related changes in articular cartilage are likely to play a role in the aetiology of osteoarthritis (OA). One of the major age-related changes in cartilage is the accumulation of advanced-glycation-endproducts (AGEs). Since, cartilage tissue is not readily available from patients for studying AGE levels, alternative approaches such as analyzing skin and urine are needed to study the role of cartilage AGE levels in OA.

METHODS

Paired human skin and cartilage samples were obtained post mortem. Paired skin and urine samples were obtained from the CHECK cohort (early OA patients). Pentosidine levels were measured by high-performance liquid chromatography (HPLC). As marker of cumulative cartilage damage X-rays of both knees and hips were scored. Urinary CTXII (uCTXII) levels were measured, to assess current cartilage breakdown.

RESULTS

Cartilage and skin pentosidine correlate well (R=0.473, P=0.05). Skin pentosidine was higher in mild (summed (Kellgren & Lawrence K&L) over four large joints ≥4) compared to no (summed K&L≤3) radiographic OA (P=0.007). Urinary pentosidine was not different between these two groups. Skin pentosidine levels were not related to cartilage breakdown (highest vs lowest tertile of uCTXII). Urinary pentosidine, however, was higher in the highest compared to the lowest uCTXII tertile (P=0.009). Multiple regression analysis showed age to be the only predictor of the summed K&L score and age, creatinine clearance and urinary pentosidine as predictors of uCTXII.

CONCLUSION

The higher skin and urinary pentosidine levels in those with mild compared to no radiographic joint damage and low vs high cartilage breakdown respectively suggest that AGEs may contribute to disease susceptibility and/or progression. However, relations are weak and cannot be used as surrogate markers of severity of OA.

Authors+Show Affiliations

Rheumatology, Amphia Ziekenhuis Breda, PO Box 90157, 4800 RL Breda, The Netherlands.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Multicenter Study
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

20673850

Citation

Vos, P A J M., et al. "Skin and Urine Pentosidine Weakly Correlate With Joint Damage in a Cohort of Patients With Early Signs of Osteoarthritis (CHECK)." Osteoarthritis and Cartilage, vol. 18, no. 10, 2010, pp. 1329-36.
Vos PA, DeGroot J, Huisman AM, et al. Skin and urine pentosidine weakly correlate with joint damage in a cohort of patients with early signs of osteoarthritis (CHECK). Osteoarthr Cartil. 2010;18(10):1329-36.
Vos, P. A., DeGroot, J., Huisman, A. M., Oostveen, J. C., Marijnissen, A. C., Bijlsma, J. W., ... Lafeber, F. P. (2010). Skin and urine pentosidine weakly correlate with joint damage in a cohort of patients with early signs of osteoarthritis (CHECK). Osteoarthritis and Cartilage, 18(10), pp. 1329-36. doi:10.1016/j.joca.2010.07.006.
Vos PA, et al. Skin and Urine Pentosidine Weakly Correlate With Joint Damage in a Cohort of Patients With Early Signs of Osteoarthritis (CHECK). Osteoarthr Cartil. 2010;18(10):1329-36. PubMed PMID: 20673850.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Skin and urine pentosidine weakly correlate with joint damage in a cohort of patients with early signs of osteoarthritis (CHECK). AU - Vos,P A J M, AU - DeGroot,J, AU - Huisman,A M, AU - Oostveen,J C M, AU - Marijnissen,A C A, AU - Bijlsma,J W J, AU - van El,B, AU - Zuurmond,A M, AU - Lafeber,F P J G, Y1 - 2010/07/29/ PY - 2009/12/20/received PY - 2010/07/01/revised PY - 2010/07/12/accepted PY - 2010/8/3/entrez PY - 2010/8/3/pubmed PY - 2011/3/17/medline SP - 1329 EP - 36 JF - Osteoarthritis and cartilage JO - Osteoarthr. Cartil. VL - 18 IS - 10 N2 - OBJECTIVES: Age-related changes in articular cartilage are likely to play a role in the aetiology of osteoarthritis (OA). One of the major age-related changes in cartilage is the accumulation of advanced-glycation-endproducts (AGEs). Since, cartilage tissue is not readily available from patients for studying AGE levels, alternative approaches such as analyzing skin and urine are needed to study the role of cartilage AGE levels in OA. METHODS: Paired human skin and cartilage samples were obtained post mortem. Paired skin and urine samples were obtained from the CHECK cohort (early OA patients). Pentosidine levels were measured by high-performance liquid chromatography (HPLC). As marker of cumulative cartilage damage X-rays of both knees and hips were scored. Urinary CTXII (uCTXII) levels were measured, to assess current cartilage breakdown. RESULTS: Cartilage and skin pentosidine correlate well (R=0.473, P=0.05). Skin pentosidine was higher in mild (summed (Kellgren & Lawrence K&L) over four large joints ≥4) compared to no (summed K&L≤3) radiographic OA (P=0.007). Urinary pentosidine was not different between these two groups. Skin pentosidine levels were not related to cartilage breakdown (highest vs lowest tertile of uCTXII). Urinary pentosidine, however, was higher in the highest compared to the lowest uCTXII tertile (P=0.009). Multiple regression analysis showed age to be the only predictor of the summed K&L score and age, creatinine clearance and urinary pentosidine as predictors of uCTXII. CONCLUSION: The higher skin and urinary pentosidine levels in those with mild compared to no radiographic joint damage and low vs high cartilage breakdown respectively suggest that AGEs may contribute to disease susceptibility and/or progression. However, relations are weak and cannot be used as surrogate markers of severity of OA. SN - 1522-9653 UR - https://www.unboundmedicine.com/medline/citation/20673850/full_citation L2 - http://linkinghub.elsevier.com/retrieve/pii/S1063-4584(10)00231-1 DB - PRIME DP - Unbound Medicine ER -