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Skin and urine pentosidine weakly correlate with joint damage in a cohort of patients with early signs of osteoarthritis (CHECK).

Abstract

OBJECTIVES

Age-related changes in articular cartilage are likely to play a role in the aetiology of osteoarthritis (OA). One of the major age-related changes in cartilage is the accumulation of advanced-glycation-endproducts (AGEs). Since, cartilage tissue is not readily available from patients for studying AGE levels, alternative approaches such as analyzing skin and urine are needed to study the role of cartilage AGE levels in OA.

METHODS

Paired human skin and cartilage samples were obtained post mortem. Paired skin and urine samples were obtained from the CHECK cohort (early OA patients). Pentosidine levels were measured by high-performance liquid chromatography (HPLC). As marker of cumulative cartilage damage X-rays of both knees and hips were scored. Urinary CTXII (uCTXII) levels were measured, to assess current cartilage breakdown.

RESULTS

Cartilage and skin pentosidine correlate well (R=0.473, P=0.05). Skin pentosidine was higher in mild (summed (Kellgren & Lawrence K&L) over four large joints ≥4) compared to no (summed K&L≤3) radiographic OA (P=0.007). Urinary pentosidine was not different between these two groups. Skin pentosidine levels were not related to cartilage breakdown (highest vs lowest tertile of uCTXII). Urinary pentosidine, however, was higher in the highest compared to the lowest uCTXII tertile (P=0.009). Multiple regression analysis showed age to be the only predictor of the summed K&L score and age, creatinine clearance and urinary pentosidine as predictors of uCTXII.

CONCLUSION

The higher skin and urinary pentosidine levels in those with mild compared to no radiographic joint damage and low vs high cartilage breakdown respectively suggest that AGEs may contribute to disease susceptibility and/or progression. However, relations are weak and cannot be used as surrogate markers of severity of OA.

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  • Authors+Show Affiliations

    ,

    Rheumatology, Amphia Ziekenhuis Breda, PO Box 90157, 4800 RL Breda, The Netherlands.

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    Source

    Osteoarthritis and cartilage 18:10 2010 Oct pg 1329-36

    MeSH

    Adult
    Aged
    Arginine
    Biomarkers
    Cartilage, Articular
    Cohort Studies
    Collagen Type II
    Female
    Humans
    Lysine
    Male
    Middle Aged
    Osteoarthritis, Hip
    Osteoarthritis, Knee
    Radiography
    Severity of Illness Index
    Skin

    Pub Type(s)

    Journal Article
    Multicenter Study
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    20673850

    Citation

    Vos, P A J M., et al. "Skin and Urine Pentosidine Weakly Correlate With Joint Damage in a Cohort of Patients With Early Signs of Osteoarthritis (CHECK)." Osteoarthritis and Cartilage, vol. 18, no. 10, 2010, pp. 1329-36.
    Vos PA, DeGroot J, Huisman AM, et al. Skin and urine pentosidine weakly correlate with joint damage in a cohort of patients with early signs of osteoarthritis (CHECK). Osteoarthr Cartil. 2010;18(10):1329-36.
    Vos, P. A., DeGroot, J., Huisman, A. M., Oostveen, J. C., Marijnissen, A. C., Bijlsma, J. W., ... Lafeber, F. P. (2010). Skin and urine pentosidine weakly correlate with joint damage in a cohort of patients with early signs of osteoarthritis (CHECK). Osteoarthritis and Cartilage, 18(10), pp. 1329-36. doi:10.1016/j.joca.2010.07.006.
    Vos PA, et al. Skin and Urine Pentosidine Weakly Correlate With Joint Damage in a Cohort of Patients With Early Signs of Osteoarthritis (CHECK). Osteoarthr Cartil. 2010;18(10):1329-36. PubMed PMID: 20673850.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Skin and urine pentosidine weakly correlate with joint damage in a cohort of patients with early signs of osteoarthritis (CHECK). AU - Vos,P A J M, AU - DeGroot,J, AU - Huisman,A M, AU - Oostveen,J C M, AU - Marijnissen,A C A, AU - Bijlsma,J W J, AU - van El,B, AU - Zuurmond,A M, AU - Lafeber,F P J G, Y1 - 2010/07/29/ PY - 2009/12/20/received PY - 2010/07/01/revised PY - 2010/07/12/accepted PY - 2010/8/3/entrez PY - 2010/8/3/pubmed PY - 2011/3/17/medline SP - 1329 EP - 36 JF - Osteoarthritis and cartilage JO - Osteoarthr. Cartil. VL - 18 IS - 10 N2 - OBJECTIVES: Age-related changes in articular cartilage are likely to play a role in the aetiology of osteoarthritis (OA). One of the major age-related changes in cartilage is the accumulation of advanced-glycation-endproducts (AGEs). Since, cartilage tissue is not readily available from patients for studying AGE levels, alternative approaches such as analyzing skin and urine are needed to study the role of cartilage AGE levels in OA. METHODS: Paired human skin and cartilage samples were obtained post mortem. Paired skin and urine samples were obtained from the CHECK cohort (early OA patients). Pentosidine levels were measured by high-performance liquid chromatography (HPLC). As marker of cumulative cartilage damage X-rays of both knees and hips were scored. Urinary CTXII (uCTXII) levels were measured, to assess current cartilage breakdown. RESULTS: Cartilage and skin pentosidine correlate well (R=0.473, P=0.05). Skin pentosidine was higher in mild (summed (Kellgren & Lawrence K&L) over four large joints ≥4) compared to no (summed K&L≤3) radiographic OA (P=0.007). Urinary pentosidine was not different between these two groups. Skin pentosidine levels were not related to cartilage breakdown (highest vs lowest tertile of uCTXII). Urinary pentosidine, however, was higher in the highest compared to the lowest uCTXII tertile (P=0.009). Multiple regression analysis showed age to be the only predictor of the summed K&L score and age, creatinine clearance and urinary pentosidine as predictors of uCTXII. CONCLUSION: The higher skin and urinary pentosidine levels in those with mild compared to no radiographic joint damage and low vs high cartilage breakdown respectively suggest that AGEs may contribute to disease susceptibility and/or progression. However, relations are weak and cannot be used as surrogate markers of severity of OA. SN - 1522-9653 UR - https://www.unboundmedicine.com/medline/citation/20673850/full_citation L2 - http://linkinghub.elsevier.com/retrieve/pii/S1063-4584(10)00231-1 DB - PRIME DP - Unbound Medicine ER -