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Physiologic insulin delivery with insulin feedback: a control systems perspective.
Comput Methods Programs Biomed. 2011 May; 102(2):130-7.CM

Abstract

Individuals with type 1 diabetes mellitus must effectively manage glycemia to avoid acute and chronic complications related to aberrations of glucose levels. Because optimal diabetes management can be difficult to achieve and burdensome, research into a closed-loop insulin delivery system has been of interest for several decades. This paper provides an overview, from a control systems perspective, of the research and development effort of a particular algorithm--the external physiologic insulin delivery system. In particular the introduction of insulin feedback, based on β-cell physiology, is covered in detail. A summary of human clinical trials is provided in the context of the evolution of this algorithm, and this paper outlines some of the research avenues that show particular promise.

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Authors+Show Affiliations

Palerm CC
Medtronic Diabetes, Closed Loop R&D, 18000 Devonshire St., Northridge, CA 91325, USA. cesar.c.palerm@medtronic.com

MeSH

AlgorithmsBlood GlucoseClinical Trials as TopicComputer SimulationDiabetes Mellitus, Type 1Feedback, PhysiologicalHumansInsulinInsulin Infusion SystemsInsulin-Secreting CellsModels, Biological

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

20674062

Citation

Palerm, Cesar C.. "Physiologic Insulin Delivery With Insulin Feedback: a Control Systems Perspective." Computer Methods and Programs in Biomedicine, vol. 102, no. 2, 2011, pp. 130-7.
Palerm CC. Physiologic insulin delivery with insulin feedback: a control systems perspective. Comput Methods Programs Biomed. 2011;102(2):130-7.
Palerm, C. C. (2011). Physiologic insulin delivery with insulin feedback: a control systems perspective. Computer Methods and Programs in Biomedicine, 102(2), 130-7. https://doi.org/10.1016/j.cmpb.2010.06.007
Palerm CC. Physiologic Insulin Delivery With Insulin Feedback: a Control Systems Perspective. Comput Methods Programs Biomed. 2011;102(2):130-7. PubMed PMID: 20674062.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Physiologic insulin delivery with insulin feedback: a control systems perspective. A1 - Palerm,Cesar C, Y1 - 2010/08/02/ PY - 2009/12/24/received PY - 2010/06/08/revised PY - 2010/06/11/accepted PY - 2010/8/3/entrez PY - 2010/8/3/pubmed PY - 2011/8/25/medline SP - 130 EP - 7 JF - Computer methods and programs in biomedicine JO - Comput Methods Programs Biomed VL - 102 IS - 2 N2 - Individuals with type 1 diabetes mellitus must effectively manage glycemia to avoid acute and chronic complications related to aberrations of glucose levels. Because optimal diabetes management can be difficult to achieve and burdensome, research into a closed-loop insulin delivery system has been of interest for several decades. This paper provides an overview, from a control systems perspective, of the research and development effort of a particular algorithm--the external physiologic insulin delivery system. In particular the introduction of insulin feedback, based on β-cell physiology, is covered in detail. A summary of human clinical trials is provided in the context of the evolution of this algorithm, and this paper outlines some of the research avenues that show particular promise. SN - 1872-7565 UR - https://www.unboundmedicine.com/medline/citation/20674062/Physiologic_insulin_delivery_with_insulin_feedback:_a_control_systems_perspective_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0169-2607(10)00150-1 DB - PRIME DP - Unbound Medicine ER -