Tags

Type your tag names separated by a space and hit enter

The prevalence and risk factors for cholelithiasis and asymptomatic gallstones in adults with congenital heart disease.
Int J Cardiol. 2011 Oct 20; 152(2):171-6.IJ

Abstract

PURPOSE

Cyanosis is considered to be a risk factor for cholelithiasis which is an important complication of cyanotic congenital heart disease (CCHD) in adults. In this study, the prevalence of cholelithiasis and asymptomatic calcium bilirubinate gallstones was evaluated in adults with congenital heart disease (CHD). Furthermore, risk factors for this potentially high risk complication were assessed.

MATERIALS AND METHODS

Subjects were derived from 114 consecutive congenital patients who visited our center from May 2008 to January 2009. For analyses of risk factors, we divided them into 4 groups: group A, 15 CCHD patients without reparative surgery (7 men, 31.8 ± 7.0 years old); group B, 41 CCHD patients rendered acyanotic by reparative surgery (21 men, 32.5 ± 11.8 years old); group C, 23 unoperated acyanotic CHD patients (11 men, 42.4 ± 16.4 years old); and group D, 35 patients who were acyanotic before and after operation (18 men, 36.3 ± 14.8 years old). Gallstones were identified by abdominal ultrasound and risk factors were analyzed by a multivariate logistic regression model.

RESULTS

Cholecystectomy was performed in 5/114 (4.3%), asymptomatic gallstones were seen in 16/114 (14%), and symptomatic gallstones except for patients after cholecystectomy were seen in 7/114 (6.1%). In group A, 4 (27%) with gallstones underwent cholecystectomy (p<0.01). Non-cholesterol gallstones were observed in 5 patients (33%) in group A, 12 patients (29%) in group B, nobody in group C, and 3 patients (8.6%) in group D. By a multivariate logistic regression model, CCHD by nature regardless of repair, prolonged cyanosis periods, higher frequency of cardiopulmonary bypass (CPB), and lower platelet counts were significant factors predicting gallstones (odds ratio 4.48, 1.08, 3.96, and 0.87, 95% CI, 1.14-17.5, 1.00-1.18, 1.65-9.54, and 0.75-0.99, respectively).

CONCLUSIONS

The prevalence of cholelithiasis and asymptomatic gallstones is significantly high in CCHD patients regardless of cardiac repairs. CCHD by nature, prolonged cyanosis durations, high frequency of CPB and low platelet counts have influences on gallstone formation in adults with CHD.

Authors+Show Affiliations

Department of Adult Congenital Heart Disease and Pediatrics, Chiba Cardiovascular Center, 575 Tsurumai, Ichihara, Chiba 290-0512, Japan.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

20675000

Citation

Shiina, Yumi, et al. "The Prevalence and Risk Factors for Cholelithiasis and Asymptomatic Gallstones in Adults With Congenital Heart Disease." International Journal of Cardiology, vol. 152, no. 2, 2011, pp. 171-6.
Shiina Y, Toyoda T, Kawasoe Y, et al. The prevalence and risk factors for cholelithiasis and asymptomatic gallstones in adults with congenital heart disease. Int J Cardiol. 2011;152(2):171-6.
Shiina, Y., Toyoda, T., Kawasoe, Y., Tateno, S., Shirai, T., Matsuo, K., Mizuno, Y., Ai, T., & Niwa, K. (2011). The prevalence and risk factors for cholelithiasis and asymptomatic gallstones in adults with congenital heart disease. International Journal of Cardiology, 152(2), 171-6. https://doi.org/10.1016/j.ijcard.2010.07.011
Shiina Y, et al. The Prevalence and Risk Factors for Cholelithiasis and Asymptomatic Gallstones in Adults With Congenital Heart Disease. Int J Cardiol. 2011 Oct 20;152(2):171-6. PubMed PMID: 20675000.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The prevalence and risk factors for cholelithiasis and asymptomatic gallstones in adults with congenital heart disease. AU - Shiina,Yumi, AU - Toyoda,Tomohiko, AU - Kawasoe,Yasutaka, AU - Tateno,Shigeru, AU - Shirai,Takeaki, AU - Matsuo,Kozo, AU - Mizuno,Yoshiko, AU - Ai,Toshiji, AU - Niwa,Koichiro, Y1 - 2010/08/01/ PY - 2009/12/21/received PY - 2010/06/12/revised PY - 2010/07/02/accepted PY - 2010/8/3/entrez PY - 2010/8/3/pubmed PY - 2012/3/1/medline SP - 171 EP - 6 JF - International journal of cardiology JO - Int J Cardiol VL - 152 IS - 2 N2 - PURPOSE: Cyanosis is considered to be a risk factor for cholelithiasis which is an important complication of cyanotic congenital heart disease (CCHD) in adults. In this study, the prevalence of cholelithiasis and asymptomatic calcium bilirubinate gallstones was evaluated in adults with congenital heart disease (CHD). Furthermore, risk factors for this potentially high risk complication were assessed. MATERIALS AND METHODS: Subjects were derived from 114 consecutive congenital patients who visited our center from May 2008 to January 2009. For analyses of risk factors, we divided them into 4 groups: group A, 15 CCHD patients without reparative surgery (7 men, 31.8 ± 7.0 years old); group B, 41 CCHD patients rendered acyanotic by reparative surgery (21 men, 32.5 ± 11.8 years old); group C, 23 unoperated acyanotic CHD patients (11 men, 42.4 ± 16.4 years old); and group D, 35 patients who were acyanotic before and after operation (18 men, 36.3 ± 14.8 years old). Gallstones were identified by abdominal ultrasound and risk factors were analyzed by a multivariate logistic regression model. RESULTS: Cholecystectomy was performed in 5/114 (4.3%), asymptomatic gallstones were seen in 16/114 (14%), and symptomatic gallstones except for patients after cholecystectomy were seen in 7/114 (6.1%). In group A, 4 (27%) with gallstones underwent cholecystectomy (p<0.01). Non-cholesterol gallstones were observed in 5 patients (33%) in group A, 12 patients (29%) in group B, nobody in group C, and 3 patients (8.6%) in group D. By a multivariate logistic regression model, CCHD by nature regardless of repair, prolonged cyanosis periods, higher frequency of cardiopulmonary bypass (CPB), and lower platelet counts were significant factors predicting gallstones (odds ratio 4.48, 1.08, 3.96, and 0.87, 95% CI, 1.14-17.5, 1.00-1.18, 1.65-9.54, and 0.75-0.99, respectively). CONCLUSIONS: The prevalence of cholelithiasis and asymptomatic gallstones is significantly high in CCHD patients regardless of cardiac repairs. CCHD by nature, prolonged cyanosis durations, high frequency of CPB and low platelet counts have influences on gallstone formation in adults with CHD. SN - 1874-1754 UR - https://www.unboundmedicine.com/medline/citation/20675000/The_prevalence_and_risk_factors_for_cholelithiasis_and_asymptomatic_gallstones_in_adults_with_congenital_heart_disease_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0167-5273(10)00538-3 DB - PRIME DP - Unbound Medicine ER -